SciTegic07090714182D 14 15 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 -0.0031 3.0008 0.0000 O 0 0 -1.3039 3.7494 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.6061 6.0003 0.0000 C 0 0 -0.0080 6.0003 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -0.0080 7.5003 0.0000 C 0 0 -2.6061 7.5003 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 2 4 1 0 3 2 1 0 4 6 1 0 5 3 1 0 6 1 2 0 7 1 1 0 8 11 1 0 9 5 2 0 10 5 1 0 11 7 2 0 12 10 2 0 13 9 1 0 14 12 1 0 4 8 2 0 13 14 2 0 M END > 146922 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 3.0000 $$$$ SciTegic07090714182D 17 19 0 0 0 0 999 V2000 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 5.5858 4.6718 0.0000 N 0 0 5.0484 7.2137 0.0000 N 0 0 2.1812 2.6271 0.0000 C 0 0 6.0509 6.0979 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 3.1158 5.4773 0.0000 C 0 0 3.5808 6.9034 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 1 0 5 1 1 0 6 10 2 0 7 13 1 0 8 2 1 0 9 6 1 0 10 11 1 0 11 8 1 0 12 10 1 0 13 12 2 0 14 4 2 0 15 5 2 0 16 17 2 0 17 15 1 0 2 4 1 0 14 16 1 0 9 7 2 0 M END > 146931 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 3.1427 $$$$ SciTegic07090714182D 18 20 0 0 0 0 999 V2000 2.5987 -1.5004 0.0000 C 0 0 3.9511 -0.8815 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 N 0 0 4.9531 -1.9978 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 5.1020 3.4627 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 5.4389 4.6145 0.0000 F 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 2 2 0 6 2 1 0 7 1 1 0 8 7 1 0 9 6 1 0 10 6 2 0 11 12 2 0 12 10 1 0 13 9 2 0 14 11 1 0 15 8 2 0 16 7 2 0 17 18 2 0 18 16 1 0 5 4 1 0 15 17 1 0 11 13 1 0 M END > 113449 > J. Med. Chem. 46(19)-2003 3953-3956 > p38a > 5.1675 $$$$ SciTegic07090714182D 19 21 0 0 0 0 999 V2000 -3.8757 -6.0130 0.0000 C 0 0 -3.8669 -7.5130 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.5870 -3.7544 0.0000 O 0 0 -2.5812 -5.2552 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2907 -2.9981 0.0000 C 0 0 -4.9185 -5.4192 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2 1 2 0 3 6 2 0 4 5 1 0 5 1 1 0 6 7 1 0 7 4 1 0 8 1 1 0 9 3 1 0 10 12 2 0 11 2 1 0 12 6 1 0 13 3 1 0 14 10 1 0 15 5 2 0 16 9 1 0 17 15 1 0 18 13 2 0 19 18 1 0 11 17 2 0 9 14 2 0 19 16 2 0 M END > 146924 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 4.3565 $$$$ SciTegic07090714182D 19 21 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2919 2.9980 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 0.0099 3.7437 0.0000 C 0 0 -2.5882 3.7528 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 1.0470 3.1401 0.0000 Cl 0 0 -3.6296 3.1565 0.0000 Cl 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2813 5.9982 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 0.0151 5.2437 0.0000 C 0 0 -2.5829 5.2528 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 1 1 0 5 2 1 0 6 4 1 0 7 6 1 0 8 3 2 0 9 3 1 0 10 2 2 0 11 8 1 0 12 9 1 0 13 4 2 0 14 17 1 0 15 6 2 0 16 8 1 0 17 9 2 0 18 13 1 0 19 18 2 0 5 7 1 0 16 14 2 0 15 19 1 0 M END > 138311 > Bioorg. Med. Chem. Lett. 14(2)-2004 357-360 > p38a > 4.9281 $$$$ SciTegic07090714182D 20 22 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 C 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 N 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 6.4437 -1.8466 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.1955 0.2934 0.0000 N 0 0 6.9354 -0.7520 0.0000 O 0 0 7.3221 -3.0635 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 8.8147 -2.9144 0.0000 C 0 0 6.7051 -4.4308 0.0000 C 0 0 7.5807 -5.6488 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 9.6903 -4.1323 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 9.0732 -5.4995 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 5 2 0 5 1 1 0 6 1 1 0 7 3 1 0 8 2 1 0 9 6 2 0 10 6 1 0 11 7 2 0 12 7 1 0 13 10 2 0 14 10 1 0 15 14 2 0 16 11 1 0 17 12 2 0 18 13 1 0 19 17 1 0 20 15 1 0 3 4 1 0 20 18 2 0 19 16 2 0 M END > 167974 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 5.6383 $$$$ SciTegic07090714182D 20 22 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 2.5987 -1.5004 0.0000 C 0 0 4.2010 -3.2956 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.8092 -4.6676 0.0000 C 0 0 4.2567 0.5852 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 4.0212 -5.9381 0.0000 C 0 0 6.3104 -4.7094 0.0000 C 0 0 5.3963 0.9614 0.0000 C 0 0 3.3615 1.3842 0.0000 C 0 0 7.0198 -6.0311 0.0000 C 0 0 4.7306 -7.2598 0.0000 C 0 0 6.2299 -7.3062 0.0000 C 0 0 2 1 1 0 3 5 1 0 4 2 2 0 5 1 2 0 6 4 1 0 7 5 1 0 8 2 1 0 9 11 1 0 10 12 1 0 11 13 2 0 12 6 2 0 13 6 1 0 14 7 2 0 15 7 1 0 16 8 1 0 17 8 1 0 18 15 2 0 19 14 1 0 20 18 1 0 4 3 1 0 19 20 2 0 10 9 2 0 M END > 52143 > J. Med. Chem. 42(12)-1999 2180-2190 > p38a > 5.6778 $$$$ SciTegic07090714182D 20 23 0 0 0 0 999 V2000 -1.2919 -2.9980 0.0000 C 0 0 -2.5034 -3.8610 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.0364 -5.2864 0.0000 N 0 0 -3.9291 -3.3923 0.0000 C 0 0 -0.5364 -5.2827 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -0.0764 -3.8550 0.0000 C 0 0 -4.4802 -2.0163 0.0000 S 0 0 -1.2964 1.4973 0.0000 N 0 0 -5.0453 -4.3766 0.0000 C 0 0 -5.9755 -2.1349 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -6.3247 -3.5937 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 2 1 0 6 8 1 0 7 3 2 0 8 1 2 0 9 5 1 0 10 15 1 0 11 5 2 0 12 9 1 0 13 7 1 0 14 11 1 0 15 16 2 0 16 3 1 0 17 7 1 0 18 13 1 0 19 17 2 0 20 19 1 0 6 4 1 0 10 13 2 0 12 14 2 0 18 20 2 0 M END > 113446 > J. Med. Chem. 46(19)-2003 3953-3956 > p38a > 6.3979 $$$$ SciTegic07090714182D 21 24 0 0 0 0 999 V2000 -2.5034 -3.8610 0.0000 C 0 0 -1.2919 -2.9980 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -0.0764 -3.8550 0.0000 N 0 0 -0.5364 -5.2827 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.0364 -5.2864 0.0000 C 0 0 -3.9291 -3.3923 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 -4.3491 -1.9577 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -5.8068 -1.6039 0.0000 C 0 0 -4.9620 -4.4825 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -6.8421 -2.6893 0.0000 C 0 0 -6.4197 -4.1286 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 2 2 0 5 7 1 0 6 3 1 0 7 1 2 0 8 1 1 0 9 12 2 0 10 8 2 0 11 6 1 0 12 13 1 0 13 3 2 0 14 6 2 0 15 10 1 0 16 8 1 0 17 11 2 0 18 14 1 0 19 20 1 0 20 16 2 0 21 18 2 0 5 4 1 0 19 15 2 0 9 11 1 0 21 17 1 0 M END > 113443 > J. Med. Chem. 46(19)-2003 3953-3956 > p38a > 5.1135 $$$$ SciTegic07090714182D 21 22 0 0 0 0 999 V2000 3.8912 -5.2578 0.0000 C 0 0 4.6332 -7.5468 0.0000 N 0 0 2.6747 -6.1134 0.0000 C 0 0 5.1017 -6.1218 0.0000 N 0 0 3.1332 -7.5416 0.0000 C 0 0 3.8933 -3.7570 0.0000 N 0 0 2.5951 -3.0039 0.0000 C 0 0 2.2484 -8.7506 0.0000 C 0 0 2.5973 -1.5031 0.0000 N 0 0 1.5548 -3.6021 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 6.2421 -5.7482 0.0000 C 0 0 -2.3383 1.3500 0.0000 Cl 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.0553 -8.6218 0.0000 C 0 0 2.7330 -9.8484 0.0000 C 0 0 1.5401 -9.7194 0.0000 C 0 0 2 4 1 0 3 1 2 0 4 1 1 0 5 3 1 0 6 1 1 0 7 6 1 0 8 5 1 0 9 7 1 0 10 7 2 0 11 9 1 0 12 17 2 0 13 4 1 0 14 12 1 0 15 11 1 0 16 11 2 0 17 16 1 0 18 15 2 0 19 8 1 0 20 8 1 0 21 8 1 0 5 2 2 0 18 12 1 0 M END > 95572 > J. Med. Chem. 45(14)-2002 2994-3008 > p38a > 5.2291 $$$$ SciTegic07090714182D 21 24 0 0 0 0 999 V2000 3.9511 -0.8815 0.0000 N 0 0 2.5987 -1.5004 0.0000 C 0 0 4.2010 -3.2956 0.0000 N 0 0 2.7343 -2.9815 0.0000 C 0 0 4.9531 -1.9978 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 3.8976 1.9590 0.0000 C 0 0 5.3308 1.5164 0.0000 C 0 0 1.6115 -3.9772 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 0.1606 -3.6178 0.0000 C 0 0 2.0333 -5.4186 0.0000 C 0 0 -0.4625 -6.1401 0.0000 C 0 0 0.9937 -6.4998 0.0000 C 0 0 -0.8791 -4.6991 0.0000 C 0 0 -1.2943 -7.0051 0.0000 F 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2 1 1 0 3 5 2 0 4 2 2 0 5 1 1 0 6 1 1 0 7 6 1 0 8 6 1 0 9 4 1 0 10 2 1 0 11 19 2 0 12 9 1 0 13 9 2 0 14 15 2 0 15 13 1 0 16 12 2 0 17 14 1 0 18 20 2 0 19 21 1 0 20 10 1 0 21 10 2 0 8 7 1 0 4 3 1 0 11 18 1 0 16 14 1 0 M END > 33064 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 7.0969 $$$$ SciTegic07090714182D 22 25 0 0 0 0 999 V2000 2.1968 0.6852 0.0000 C 0 0 0.9876 1.5922 0.0000 N 0 0 1.7333 -0.7256 0.0000 C 0 0 0.2217 -0.7054 0.0000 N 0 0 -0.2419 0.7054 0.0000 C 0 0 3.6284 1.1358 0.0000 C 0 0 2.6053 -1.9470 0.0000 C 0 0 4.5346 -4.2398 0.0000 N 0 0 4.7992 0.2058 0.0000 C 0 0 3.8440 2.6219 0.0000 C 0 0 -0.9876 -1.5720 0.0000 C 0 0 -1.7333 0.7457 0.0000 C 0 0 6.4140 2.2411 0.0000 C 0 0 7.8108 2.7901 0.0000 S 0 0 6.1942 0.7573 0.0000 C 0 0 5.2389 3.1734 0.0000 C 0 0 -2.1968 -0.7054 0.0000 C 0 0 3.0574 -4.5004 0.0000 C 0 0 5.0476 -2.8303 0.0000 C 0 0 2.0932 -3.3514 0.0000 C 0 0 4.0834 -1.6813 0.0000 C 0 0 8.7498 2.0429 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 2 2 0 6 1 1 0 7 3 1 0 8 19 2 0 9 6 2 0 10 6 1 0 11 4 1 0 12 5 1 0 13 16 1 0 14 13 1 0 15 9 1 0 16 10 2 0 17 11 1 0 18 20 2 0 19 21 1 0 20 7 1 0 21 7 2 0 22 14 1 0 4 5 1 0 15 13 2 0 18 8 1 0 12 17 1 0 M END > 33084 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 4.0000 $$$$ SciTegic07090714182D 22 25 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 2.1749 2.6315 0.0000 C 0 0 4.0896 0.0290 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 7.0761 0.2776 0.0000 N 0 0 1.2517 3.8078 0.0000 C 0 0 3.6621 2.8384 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 3.2965 5.4106 0.0000 C 0 0 4.2218 4.2301 0.0000 C 0 0 1.8114 5.1995 0.0000 C 0 0 3.7442 6.5239 0.0000 F 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 4.9397 -1.2009 0.0000 C 0 0 4.7275 1.3885 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 3 1 0 6 2 1 0 7 1 1 0 8 13 1 0 9 20 2 0 10 6 1 0 11 6 2 0 12 5 2 0 13 4 2 0 14 15 2 0 15 11 1 0 16 10 2 0 17 14 1 0 18 12 1 0 19 21 2 0 20 22 1 0 21 7 1 0 22 7 2 0 5 4 1 0 9 19 1 0 18 8 2 0 14 16 1 0 M END > 114464 > J. Med. Chem. 46(22)-2003 4702-4713 > p38a > 5.5086 $$$$ SciTegic07090714182D 22 25 0 0 0 0 999 V2000 3.9511 -0.8815 0.0000 N 0 0 4.2010 -3.2956 0.0000 N 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 C 0 0 4.9531 -1.9978 0.0000 C 0 0 4.2568 0.5852 0.0000 C 0 0 1.6115 -3.9772 0.0000 C 0 0 5.6819 1.0556 0.0000 C 0 0 6.5960 2.1444 0.0000 C 0 0 7.0631 0.7190 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 0.1606 -3.6178 0.0000 C 0 0 2.0333 -5.4186 0.0000 C 0 0 -0.4625 -6.1401 0.0000 C 0 0 0.9937 -6.4998 0.0000 C 0 0 -0.8791 -4.6991 0.0000 C 0 0 -1.2943 -7.0051 0.0000 F 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2 5 2 0 3 1 1 0 4 3 2 0 5 1 1 0 6 1 1 0 7 4 1 0 8 6 1 0 9 8 1 0 10 8 1 0 11 3 1 0 12 20 2 0 13 7 2 0 14 7 1 0 15 16 1 0 16 14 2 0 17 13 1 0 18 15 1 0 19 21 2 0 20 22 1 0 21 11 1 0 22 11 2 0 4 2 1 0 9 10 1 0 19 12 1 0 15 17 2 0 M END > 129637 > J. Med. Chem. 47(11)-2004 2768-2775 > p38a > 6.7959 $$$$ SciTegic07090714182D 22 24 0 0 0 0 999 V2000 2.5826 -7.5048 0.0000 C 0 0 2.5973 -1.5031 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 2.5847 -6.0040 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 1.5424 -8.1030 0.0000 O 0 0 3.8809 -8.2579 0.0000 C 0 0 1.2883 -5.2495 0.0000 C 0 0 3.8864 -5.2585 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 2.3383 1.3500 0.0000 N 0 0 1.2935 -3.7495 0.0000 C 0 0 3.8915 -3.7585 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.8810 -9.7579 0.0000 C 0 0 5.1800 -7.5079 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 5.1800 -10.5079 0.0000 C 0 0 6.4790 -8.2579 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 6.4791 -9.7579 0.0000 C 0 0 2 10 1 0 3 2 1 0 4 1 1 0 5 3 2 0 6 1 2 0 7 1 1 0 8 4 2 0 9 4 1 0 10 13 1 0 11 5 1 0 12 8 1 0 13 9 2 0 14 3 1 0 15 5 1 0 16 7 1 0 17 7 2 0 18 14 2 0 19 16 2 0 20 17 1 0 21 18 1 0 22 20 2 0 10 12 2 0 22 19 1 0 21 15 2 0 M END > 115864 > J. Med. Chem. 46(26)-2003 5651-5662 > p38a > 6.8386 $$$$ SciTegic07090714182D 23 26 0 0 0 0 999 V2000 0.0000 -1.5555 0.0000 N 0 0 -2.3471 -0.6805 0.0000 C 0 0 -0.9027 -0.2778 0.0000 C 0 0 -1.0416 -2.7220 0.0000 C 0 0 -2.3887 -2.1665 0.0000 N 0 0 -3.4303 0.3889 0.0000 C 0 0 -3.0415 1.8471 0.0000 C 0 0 -1.5832 2.2082 0.0000 C 0 0 -0.5416 1.1527 0.0000 C 0 0 -4.0970 2.9026 0.0000 C 0 0 -5.5413 2.5415 0.0000 N 0 0 -0.7287 -4.1874 0.0000 C 0 0 0.8888 1.5138 0.0000 C 0 0 -4.8608 0.0417 0.0000 C 0 0 -5.9163 1.0971 0.0000 C 0 0 -1.2360 3.6525 0.0000 C 0 0 -3.7766 4.0590 0.0000 O 0 0 0.1944 4.0414 0.0000 C 0 0 1.3055 2.9581 0.0000 C 0 0 0.4956 5.2030 0.0000 F 0 0 0.4126 -4.5583 0.0000 C 0 0 -1.6203 -4.9906 0.0000 C 0 0 -0.4791 -5.3612 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 1 2 0 5 4 1 0 6 2 1 0 7 8 1 0 8 9 1 0 9 3 1 0 10 7 1 0 11 10 1 0 12 4 1 0 13 9 2 0 14 6 1 0 15 14 2 0 16 8 2 0 17 10 2 0 18 19 2 0 19 13 1 0 20 18 1 0 21 12 1 0 22 12 1 0 23 12 1 0 2 5 1 0 6 7 2 0 18 16 1 0 11 15 1 0 M END > 136105 > Bioorg. Med. Chem. Lett. 12(8)-2002 1219-1223 > p38a > 5.7496 $$$$ SciTegic07090714182D 23 26 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 2.5987 -1.5004 0.0000 C 0 0 3.9511 -0.8815 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 4.2568 0.5878 0.0000 C 0 0 4.8092 -4.6676 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 4.0212 -5.9381 0.0000 C 0 0 6.3104 -4.7094 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 4.7306 -7.2598 0.0000 C 0 0 7.0198 -6.0311 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 6.2299 -7.3062 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 1 0 5 1 2 0 6 2 1 0 7 6 1 0 8 3 1 0 9 5 1 0 10 13 2 0 11 7 2 0 12 6 2 0 13 12 1 0 14 8 2 0 15 8 1 0 16 9 1 0 17 9 2 0 18 15 2 0 19 16 2 0 20 17 1 0 21 14 1 0 22 18 1 0 23 20 2 0 2 4 1 0 19 23 1 0 21 22 2 0 10 11 1 0 M END > 52150 > J. Med. Chem. 42(12)-1999 2180-2190 > p38a > 6.1549 $$$$ SciTegic07090714182D 23 26 0 0 0 0 999 V2000 -3.9086 1.5029 0.0000 C 0 0 -5.2640 0.8910 0.0000 C 0 0 -6.2601 2.0125 0.0000 N 0 0 -5.5014 3.3065 0.0000 C 0 0 -4.0363 2.9847 0.0000 S 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 -5.5772 -0.5767 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -5.9820 4.4060 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -4.5496 -1.6621 0.0000 C 0 0 -7.0393 -0.9198 0.0000 C 0 0 -6.4373 -3.4472 0.0000 C 0 0 -7.4679 -2.3573 0.0000 C 0 0 -4.9781 -3.0996 0.0000 C 0 0 -6.7802 -4.5971 0.0000 F 0 0 2.5929 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 5 1 0 5 1 1 0 6 1 1 0 7 6 2 0 8 2 1 0 9 7 1 0 10 11 2 0 11 14 1 0 12 6 1 0 13 4 1 0 14 12 2 0 15 8 1 0 16 8 2 0 17 18 2 0 18 16 1 0 19 15 2 0 20 17 1 0 21 10 1 0 22 9 2 0 23 22 1 0 3 4 2 0 11 9 1 0 17 19 1 0 23 21 2 0 M END > 131915 > J. Med. Chem. 47(18)-2004 4494-4506 > p38a > 6.3098 $$$$ SciTegic07090714182D 23 24 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 0.0000 -1.5000 0.0000 N 0 0 -1.2990 0.7500 0.0000 N 0 0 2.5988 1.5004 0.0000 C 0 0 -0.0125 -5.9981 0.0000 C 0 0 3.6380 2.1004 0.0000 N 0 0 1.2883 -5.2495 0.0000 C 0 0 1.2935 -3.7495 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 3.8915 -3.7585 0.0000 C 0 0 -1.0507 -5.3963 0.0000 O 0 0 2.5847 -6.0040 0.0000 C 0 0 -0.0156 -7.4989 0.0000 N 0 0 3.8864 -5.2585 0.0000 C 0 0 -0.0031 3.0008 0.0000 N 0 0 -1.3163 -8.2475 0.0000 O 0 0 4.9329 -3.1621 0.0000 C 0 0 -1.0432 3.5993 0.0000 C 0 0 -1.3188 -9.4475 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 3 1 0 6 1 2 0 7 13 2 0 8 2 1 0 9 11 1 0 10 8 3 0 11 12 1 0 12 5 2 0 13 6 1 0 14 5 1 0 15 9 2 0 16 18 1 0 17 9 1 0 18 14 2 0 19 4 1 0 20 17 1 0 21 14 1 0 22 19 1 0 23 20 1 0 7 4 1 0 16 11 2 0 M END > 162194 > J. Med. Chem. 48(20)-2005 6261-6270 > p38a > 7.7959 $$$$ SciTegic07090714182D 24 26 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -0.0031 3.0008 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -2.3421 3.1476 0.0000 O 0 0 2.6003 -1.4977 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 7.7985 -1.4932 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 3.8990 -0.7455 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 0.0000 -2.7000 0.0000 Cl 0 0 5.2003 -1.4932 0.0000 C 0 0 6.4994 -0.7432 0.0000 C 0 0 7.7985 -2.9932 0.0000 C 0 0 -2.6061 6.0003 0.0000 C 0 0 -0.0080 6.0003 0.0000 C 0 0 5.2004 -2.9933 0.0000 C 0 0 6.4995 -3.7432 0.0000 C 0 0 -0.0080 7.5003 0.0000 C 0 0 -2.6061 7.5003 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 2 6 2 0 3 1 1 0 4 11 2 0 5 3 1 0 6 5 1 0 7 1 2 0 8 2 1 0 9 1 1 0 10 16 2 0 11 13 1 0 12 8 1 0 13 5 2 0 14 4 1 0 15 12 1 0 16 15 1 0 17 21 2 0 18 9 2 0 19 9 1 0 20 15 2 0 21 20 1 0 22 19 2 0 23 18 1 0 24 22 1 0 23 24 2 0 4 2 1 0 10 17 1 0 M END > 146927 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 4.5229 $$$$ SciTegic07090714182D 24 27 0 0 0 0 999 V2000 -3.6217 1.4865 0.0000 C 0 0 -4.9153 0.7255 0.0000 N 0 0 -2.3155 0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 -7.4980 -0.8010 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 -1.0028 1.5132 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -3.6319 2.6865 0.0000 O 0 0 -6.2219 1.4621 0.0000 C 0 0 -4.9001 -0.7745 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -8.7916 -1.5619 0.0000 C 0 0 -7.5133 0.6990 0.0000 C 0 0 -6.1914 -1.5377 0.0000 C 0 0 -10.0979 -0.8229 0.0000 C 0 0 -11.3920 -1.5816 0.0000 C 0 0 -10.1081 0.6771 0.0000 C 0 0 -11.4121 1.4184 0.0000 C 0 0 -12.6960 -0.8403 0.0000 C 0 0 -12.7061 0.6597 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 7 2 0 5 18 1 0 6 4 1 0 7 3 1 0 8 6 1 0 9 15 2 0 10 1 2 0 11 2 1 0 12 2 1 0 13 3 2 0 14 9 1 0 15 13 1 0 16 5 1 0 17 11 1 0 18 12 1 0 19 16 1 0 20 19 1 0 21 19 2 0 22 21 1 0 23 20 2 0 24 22 2 0 5 17 1 0 9 4 1 0 8 14 2 0 23 24 1 0 M END > 119697 > Bioorg. Med. Chem. Lett. 13(18)-2003 3087-3090 > p38a > 5.2581 $$$$ SciTegic07090714182D 24 27 0 0 0 0 999 V2000 1.7138 1.2033 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 3.6500 2.9355 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 6.5873 3.5462 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 1.3808 3.5211 0.0000 O 0 0 4.1200 4.3600 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 8.0561 3.8547 0.0000 C 0 0 6.1174 2.1217 0.0000 C 0 0 5.5886 4.6654 0.0000 C 0 0 8.5242 5.2806 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 9.9918 5.5911 0.0000 C 0 0 7.5216 6.3965 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 7.9866 7.8226 0.0000 C 0 0 10.4567 7.0172 0.0000 C 0 0 9.4541 8.1330 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 3 1 0 7 13 1 0 8 5 2 0 9 2 2 0 10 4 1 0 11 4 1 0 12 7 1 0 13 11 1 0 14 10 1 0 15 12 1 0 16 5 1 0 17 8 1 0 18 15 2 0 19 15 1 0 20 16 2 0 21 20 1 0 22 19 2 0 23 18 1 0 24 22 1 0 6 8 1 0 21 17 2 0 14 7 1 0 24 23 2 0 M END > 119700 > Bioorg. Med. Chem. Lett. 13(18)-2003 3087-3090 > p38a > 5.3242 $$$$ SciTegic07090714182D 24 27 0 0 0 0 999 V2000 -0.9971 3.0138 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.2935 3.7700 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 -4.8881 5.2761 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 0.0446 3.6095 0.0000 O 0 0 -2.2901 5.2700 0.0000 C 0 0 -3.5944 3.0231 0.0000 C 0 0 -6.1845 6.0323 0.0000 C 0 0 -4.8917 3.7761 0.0000 C 0 0 -3.5873 6.0231 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -6.1788 7.5331 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -7.4735 8.2908 0.0000 C 0 0 -4.8754 8.2756 0.0000 C 0 0 -4.8667 9.7756 0.0000 C 0 0 -7.4647 9.7907 0.0000 C 0 0 -6.1613 10.5332 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 14 1 0 6 7 1 0 7 4 2 0 8 9 2 0 9 4 1 0 10 1 2 0 11 3 1 0 12 3 1 0 13 5 1 0 14 12 1 0 15 11 1 0 16 2 2 0 17 13 1 0 18 16 1 0 19 18 2 0 20 17 1 0 21 17 2 0 22 21 1 0 23 20 2 0 24 22 2 0 5 15 1 0 19 7 1 0 8 6 1 0 23 24 1 0 M END > 119699 > Bioorg. Med. Chem. Lett. 13(18)-2003 3087-3090 > p38a > 5.8125 $$$$ SciTegic07090714182D 24 28 0 0 0 0 999 V2000 -1.2919 2.9980 0.0000 C 0 0 -2.5034 3.8610 0.0000 C 0 0 -0.0764 3.8550 0.0000 C 0 0 -2.0364 5.2864 0.0000 N 0 0 -0.5364 5.2827 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 1.3470 3.3793 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 2.3509 2.3787 0.0000 C 0 0 2.6901 3.8398 0.0000 C 0 0 -3.9291 3.3923 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 -4.3491 1.9577 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -5.8068 1.6039 0.0000 C 0 0 -4.9620 4.4825 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -6.8421 2.6893 0.0000 C 0 0 -6.4197 4.1286 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 1 1 0 7 3 1 0 8 6 2 0 9 7 1 0 10 7 1 0 11 2 1 0 12 16 1 0 13 11 1 0 14 8 1 0 15 6 1 0 16 15 2 0 17 8 1 0 18 13 2 0 19 11 2 0 20 14 1 0 21 17 2 0 22 23 2 0 23 19 1 0 24 21 1 0 5 4 1 0 12 14 2 0 9 10 1 0 20 24 2 0 22 18 1 0 M END > 113445 > J. Med. Chem. 46(19)-2003 3953-3956 > p38a > 6.5528 $$$$ SciTegic07090714182D 24 27 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -4.9669 0.8708 0.0000 C 0 0 -5.9732 1.9832 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -5.2262 3.2840 0.0000 C 0 0 -3.7582 2.9755 0.0000 O 0 0 -5.2668 -0.5997 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 -4.2294 -1.6758 0.0000 C 0 0 -6.7258 -0.9560 0.0000 C 0 0 -6.1009 -3.4778 0.0000 C 0 0 -7.1413 -2.3973 0.0000 C 0 0 -4.6449 -3.1171 0.0000 C 0 0 -6.4333 -4.6309 0.0000 F 0 0 3.3556 2.8737 0.0000 C 0 0 1.3808 3.5211 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 2 0 5 1 1 0 6 4 1 0 7 8 2 0 8 1 1 0 9 6 2 0 10 9 1 0 11 12 2 0 12 8 1 0 13 14 1 0 14 6 1 0 15 9 1 0 16 2 1 0 17 15 1 0 18 15 2 0 19 20 2 0 20 18 1 0 21 17 2 0 22 19 1 0 23 16 1 0 24 16 1 0 3 7 1 0 11 4 1 0 10 13 2 0 21 19 1 0 M END > 161187 > J. 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Chem. 48(18)-2005 5728-5737 > p38a > 8.3010 $$$$ SciTegic07090714182D 25 28 0 0 0 0 999 V2000 -4.9153 0.7255 0.0000 C 0 0 -8.8197 1.4467 0.0000 C 0 0 -6.2216 1.4644 0.0000 C 0 0 -10.1142 0.6875 0.0000 N 0 0 -3.6217 1.4865 0.0000 N 0 0 -7.5156 0.7056 0.0000 C 0 0 -8.8299 2.9467 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -6.2319 2.9644 0.0000 C 0 0 -7.5360 3.7055 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 -4.9050 -0.4745 0.0000 O 0 0 -12.7045 -0.8261 0.0000 O 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -7.5442 4.9055 0.0000 F 0 0 -10.1065 -0.8125 0.0000 C 0 0 -11.4173 1.4307 0.0000 C 0 0 -12.7124 0.6739 0.0000 C 0 0 -11.4016 -1.5693 0.0000 C 0 0 2 6 2 0 3 1 1 0 4 2 1 0 5 1 1 0 6 3 1 0 7 14 2 0 8 15 2 0 9 10 1 0 10 19 2 0 11 16 2 0 12 5 1 0 13 3 2 0 14 13 1 0 15 12 1 0 16 8 1 0 17 1 2 0 18 24 1 0 19 20 1 0 20 12 2 0 21 14 1 0 22 4 1 0 23 4 1 0 24 23 1 0 25 22 1 0 2 7 1 0 8 10 1 0 9 11 1 0 25 18 1 0 M END > 146934 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 3.7905 $$$$ SciTegic07090714182D 25 27 0 0 0 0 999 V2000 -3.8912 5.2578 0.0000 C 0 0 -5.1017 6.1218 0.0000 N 0 0 -4.6332 7.5468 0.0000 N 0 0 -2.6747 6.1134 0.0000 C 0 0 -3.1333 7.5416 0.0000 C 0 0 -3.8933 3.7570 0.0000 N 0 0 -2.5951 3.0039 0.0000 C 0 0 -2.2484 8.7506 0.0000 C 0 0 -2.5973 1.5031 0.0000 N 0 0 -6.5279 5.6546 0.0000 C 0 0 -1.5549 3.6021 0.0000 O 0 0 1.2990 -0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.0553 8.6218 0.0000 C 0 0 -2.7330 9.8484 0.0000 C 0 0 -1.5402 9.7193 0.0000 C 0 0 -6.9493 4.2204 0.0000 C 0 0 -7.5597 6.7458 0.0000 C 0 0 -9.0177 6.3934 0.0000 C 0 0 -8.4074 3.8681 0.0000 C 0 0 -9.4416 4.9546 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 4 1 0 6 1 1 0 7 6 1 0 8 5 1 0 9 7 1 0 10 2 1 0 11 7 2 0 12 16 1 0 13 9 1 0 14 13 2 0 15 13 1 0 16 15 2 0 17 14 1 0 18 8 1 0 19 8 1 0 20 8 1 0 21 10 2 0 22 10 1 0 23 22 2 0 24 21 1 0 25 23 1 0 5 3 2 0 25 24 2 0 12 17 2 0 M END > 95603 > J. Med. Chem. 45(14)-2002 2994-3008 > p38a > 5.9208 $$$$ SciTegic07090714182D 26 29 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 0.7917 -6.4425 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 1.6137 -3.9759 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 -1.4563 -8.4293 0.0000 O 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 1.9143 -5.4464 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 5.4388 4.6145 0.0000 F 0 0 1.0899 -7.9126 0.0000 C 0 0 -0.6306 -5.9659 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.7546 -6.9592 0.0000 C 0 0 -0.0341 -8.9060 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 1 0 5 1 2 0 6 2 1 0 7 14 1 0 8 3 1 0 9 4 1 0 10 22 1 0 11 23 1 0 12 6 2 0 13 6 1 0 14 9 1 0 15 16 1 0 16 13 2 0 17 12 1 0 18 15 1 0 19 7 1 0 20 7 1 0 21 25 1 0 22 26 2 0 23 20 1 0 24 19 1 0 25 8 2 0 26 8 1 0 4 3 1 0 17 15 2 0 21 10 2 0 24 11 1 0 M END > 33038 > J. Med. 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Med. Chem. Lett. 12(16)-2002 2109-2112 > p38a > 6.1739 $$$$ SciTegic07090714182D 26 29 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 1.0922 -7.9130 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 1.9143 -5.4464 0.0000 C 0 0 1.6137 -3.9759 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 0.7917 -6.4425 0.0000 C 0 0 5.4388 4.6145 0.0000 F 0 0 0.0777 -9.0004 0.0000 C 0 0 2.4546 -8.5096 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.2891 -10.0005 0.0000 C 0 0 0.8201 -10.3038 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 1 0 5 1 2 0 6 2 1 0 7 17 1 0 8 3 1 0 9 22 1 0 10 6 2 0 11 6 1 0 12 13 1 0 13 4 1 0 14 15 1 0 15 11 2 0 16 10 1 0 17 12 1 0 18 14 1 0 19 7 1 0 20 7 1 0 21 23 1 0 22 24 2 0 23 8 2 0 24 8 1 0 25 20 1 0 26 19 1 0 4 3 1 0 16 14 2 0 21 9 2 0 26 25 1 0 M END > 33043 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 6.4685 $$$$ SciTegic07090714182D 27 30 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 1.0922 -7.9130 0.0000 N 0 0 0.0000 1.5000 0.0000 N 0 0 1.6989 -10.8511 0.0000 O 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 1.9143 -5.4464 0.0000 C 0 0 1.6137 -3.9759 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.7917 -6.4425 0.0000 C 0 0 5.4388 4.6145 0.0000 F 0 0 -0.0283 -8.9103 0.0000 C 0 0 2.5161 -8.3849 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.8194 -9.8539 0.0000 C 0 0 0.2750 -10.3793 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 1 0 5 1 2 0 6 3 1 0 7 2 1 0 8 19 1 0 9 18 1 0 10 25 1 0 11 7 2 0 12 7 1 0 13 14 1 0 14 4 1 0 15 16 1 0 16 12 2 0 17 11 1 0 18 6 2 0 19 13 1 0 20 15 1 0 21 8 1 0 22 8 1 0 23 6 1 0 24 27 1 0 25 22 1 0 26 21 1 0 27 23 2 0 4 3 1 0 17 15 2 0 9 24 2 0 10 26 1 0 M END > 33067 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 4.1891 $$$$ SciTegic07090714182D 27 30 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 3.3372 -5.2929 0.0000 N 0 0 1.8372 -5.2877 0.0000 N 0 0 2.5973 -1.5031 0.0000 C 0 0 1.3786 -3.8595 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.2151 -6.5101 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 4.9460 -3.4943 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 -0.0048 6.0009 0.0000 N 0 0 0.0000 3.0008 0.0000 C 0 0 5.7096 -6.4704 0.0000 C 0 0 3.4940 -7.8274 0.0000 C 0 0 5.7769 -9.0677 0.0000 C 0 0 4.2774 -9.1065 0.0000 C 0 0 6.4930 -7.7496 0.0000 C 0 0 6.4037 -10.0910 0.0000 F 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.2954 5.2529 0.0000 C 0 0 -1.3026 5.2488 0.0000 C 0 0 1.2978 3.7529 0.0000 C 0 0 -1.3002 3.7488 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 6 2 0 5 1 1 0 6 1 1 0 7 5 1 0 8 3 1 0 9 7 2 0 10 9 1 0 11 2 1 0 12 5 2 0 13 25 1 0 14 10 1 0 15 8 2 0 16 8 1 0 17 18 1 0 18 16 2 0 19 15 1 0 20 17 1 0 21 7 1 0 22 23 1 0 23 21 2 0 24 26 1 0 25 27 2 0 26 14 2 0 27 14 1 0 3 4 1 0 22 10 2 0 17 19 2 0 13 24 2 0 M END > 168003 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 5.8928 $$$$ SciTegic07090714182D 27 30 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 3.3372 -5.2929 0.0000 N 0 0 1.8372 -5.2877 0.0000 N 0 0 1.3786 -3.8595 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 4.2151 -6.5101 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.9460 -3.4943 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -3.9015 3.7484 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 5.7096 -6.4704 0.0000 C 0 0 3.4940 -7.8274 0.0000 C 0 0 -2.5987 1.5004 0.0000 C 0 0 5.7769 -9.0677 0.0000 C 0 0 6.4930 -7.7496 0.0000 C 0 0 4.2774 -9.1065 0.0000 C 0 0 6.4037 -10.0910 0.0000 F 0 0 -2.6012 3.0004 0.0000 C 0 0 -5.1993 2.9963 0.0000 C 0 0 -3.8967 0.7484 0.0000 C 0 0 -5.1969 1.4963 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 5 2 0 5 1 1 0 6 1 1 0 7 3 1 0 8 6 1 0 9 2 1 0 10 6 2 0 11 15 2 0 12 24 1 0 13 8 1 0 14 8 2 0 15 14 1 0 16 13 2 0 17 7 1 0 18 7 2 0 19 11 1 0 20 22 2 0 21 17 2 0 22 18 1 0 23 20 1 0 24 19 2 0 25 27 1 0 26 19 1 0 27 26 2 0 3 4 1 0 11 16 1 0 21 20 1 0 25 12 2 0 M END > 168002 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 6.0088 $$$$ SciTegic07090714182D 27 30 0 0 0 0 999 V2000 2.5987 -1.5004 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 4.2010 -3.2956 0.0000 N 0 0 4.9531 -1.9978 0.0000 C 0 0 2.7343 -2.9815 0.0000 C 0 0 -2.5973 1.5031 0.0000 S 0 0 1.2990 -0.7500 0.0000 C 0 0 6.4458 -1.8433 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 -2.5956 2.7031 0.0000 O 0 0 5.1020 3.4627 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 7.1563 -0.5278 0.0000 C 0 0 7.2285 -3.1249 0.0000 C 0 0 9.4415 -1.7638 0.0000 C 0 0 8.7279 -3.0832 0.0000 C 0 0 8.6557 -0.4861 0.0000 C 0 0 10.6411 -1.7304 0.0000 F 0 0 -3.6375 0.9049 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 2 1 1 0 3 5 2 0 4 2 2 0 5 1 1 0 6 9 1 0 7 1 1 0 8 4 1 0 9 15 1 0 10 2 1 0 11 6 2 0 12 25 2 0 13 7 2 0 14 7 1 0 15 14 2 0 16 13 1 0 17 8 1 0 18 8 2 0 19 20 2 0 20 18 1 0 21 17 2 0 22 19 1 0 23 6 1 0 24 26 2 0 25 27 1 0 26 10 1 0 27 10 2 0 4 3 1 0 16 9 2 0 24 12 1 0 21 19 1 0 M END > 33058 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 6.1249 $$$$ SciTegic07090714182D 27 29 0 0 0 0 999 V2000 -5.1770 10.5117 0.0000 C 0 0 -6.7822 12.3044 0.0000 N 0 0 -6.5284 9.8906 0.0000 C 0 0 -5.3150 11.9926 0.0000 N 0 0 -7.5322 11.0053 0.0000 C 0 0 -3.8788 9.7587 0.0000 N 0 0 -3.8809 8.2579 0.0000 C 0 0 -9.0222 10.8487 0.0000 C 0 0 -2.5827 7.5048 0.0000 N 0 0 -4.9211 7.6596 0.0000 O 0 0 -2.5973 1.5031 0.0000 N 0 0 1.2990 -0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5848 6.0040 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 -4.4184 12.7902 0.0000 C 0 0 -1.2883 5.2495 0.0000 C 0 0 -3.8915 3.7585 0.0000 C 0 0 -3.8864 5.2585 0.0000 C 0 0 -1.2935 3.7495 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -9.5109 9.7527 0.0000 C 0 0 -9.7272 11.8197 0.0000 C 0 0 -10.2157 10.7238 0.0000 C 0 0 2 4 1 0 3 1 2 0 4 1 1 0 5 3 1 0 6 1 1 0 7 6 1 0 8 5 1 0 9 7 1 0 10 7 2 0 11 15 1 0 12 23 1 0 13 11 1 0 14 9 1 0 15 18 2 0 16 4 1 0 17 14 1 0 18 19 1 0 19 14 2 0 20 17 2 0 21 13 2 0 22 13 1 0 23 22 2 0 24 21 1 0 25 8 1 0 26 8 1 0 27 8 1 0 5 2 2 0 15 20 1 0 12 24 2 0 M END > 3535 > Bioorg. Med. Chem. Lett. 12(12)-2002 1559-1562 > p38a > 6.3768 $$$$ SciTegic07090714182D 27 30 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2919 2.9980 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 N 0 0 2.5929 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 0.0099 3.7437 0.0000 C 0 0 -2.5882 3.7528 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 3.8911 -1.5017 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 3.8890 -3.0026 0.0000 C 0 0 -3.6296 3.1565 0.0000 Cl 0 0 1.0470 3.1401 0.0000 Cl 0 0 5.1872 -3.7556 0.0000 C 0 0 -1.2813 5.9982 0.0000 C 0 0 -2.5829 5.2528 0.0000 C 0 0 0.0151 5.2437 0.0000 C 0 0 5.1872 -5.2557 0.0000 C 0 0 6.4863 -3.0057 0.0000 C 0 0 7.7853 -3.7557 0.0000 C 0 0 6.4863 -6.0057 0.0000 C 0 0 7.7853 -5.2557 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 1 1 0 5 3 2 0 6 2 1 0 7 5 1 0 8 15 1 0 9 3 1 0 10 5 1 0 11 4 2 0 12 4 1 0 13 2 2 0 14 8 1 0 15 9 2 0 16 14 1 0 17 12 1 0 18 11 1 0 19 16 1 0 20 21 1 0 21 12 2 0 22 11 1 0 23 19 2 0 24 19 1 0 25 24 2 0 26 23 1 0 27 25 1 0 22 20 2 0 6 10 1 0 7 8 2 0 26 27 2 0 M END > 136286 > Bioorg. Med. Chem. Lett. 13(22)-2003 3979-3982 > p38a > 6.9469 $$$$ SciTegic07090714182D 27 29 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.5972 1.5031 0.0000 N 0 0 2.5951 3.0039 0.0000 C 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 -0.7500 0.0000 N 0 0 2.5988 -1.5004 0.0000 C 0 0 -0.0126 5.9981 0.0000 C 0 0 -0.0031 -3.0008 0.0000 N 0 0 3.6380 -2.1004 0.0000 N 0 0 1.2883 5.2495 0.0000 C 0 0 1.2934 3.7495 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 3.8915 3.7585 0.0000 C 0 0 -1.0508 5.3963 0.0000 O 0 0 2.5847 6.0040 0.0000 C 0 0 -0.0156 7.4989 0.0000 N 0 0 3.8863 5.2585 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 -1.3164 8.2475 0.0000 O 0 0 4.9328 3.1621 0.0000 C 0 0 -1.3189 9.4475 0.0000 C 0 0 -1.4469 -5.2298 0.0000 C 0 0 -2.6531 -3.1237 0.0000 C 0 0 -2.9152 -5.5365 0.0000 C 0 0 -3.6607 -4.2349 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 4 1 0 6 2 2 0 7 3 1 0 8 1 1 0 9 12 1 0 10 3 1 0 11 8 3 0 12 13 1 0 13 5 2 0 14 7 2 0 15 5 1 0 16 9 2 0 17 19 1 0 18 9 1 0 19 15 2 0 20 10 1 0 21 18 1 0 22 15 1 0 23 21 1 0 24 20 1 0 25 20 1 0 26 24 1 0 27 25 1 0 14 6 1 0 26 27 1 0 17 12 2 0 M END > 162197 > J. Med. Chem. 48(20)-2005 6261-6270 > p38a > 9.3768 $$$$ SciTegic07090714182D 28 32 0 0 0 0 999 V2000 -3.7582 2.9755 0.0000 N 0 0 -4.9669 0.8708 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -5.9732 1.9832 0.0000 N 0 0 -5.2262 3.2840 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -7.7677 10.0150 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 -5.2668 -0.5997 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -5.8397 4.6536 0.0000 C 0 0 -7.3609 8.8861 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 1.7138 1.2033 0.0000 O 0 0 1.7138 -1.2033 0.0000 O 0 0 -4.2293 -1.6758 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -7.3114 4.9170 0.0000 C 0 0 -4.8672 5.7978 0.0000 C 0 0 -6.8521 7.4742 0.0000 C 0 0 -5.3757 7.2090 0.0000 C 0 0 -7.8199 6.3282 0.0000 C 0 0 -4.6449 -3.1171 0.0000 C 0 0 -6.7258 -0.9560 0.0000 C 0 0 -6.1008 -3.4778 0.0000 C 0 0 -7.1413 -2.3973 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 1 0 5 1 2 0 6 3 1 0 7 12 3 0 8 10 1 0 9 2 1 0 10 6 2 0 11 5 1 0 12 22 1 0 13 19 1 0 14 8 1 0 15 13 1 0 16 9 1 0 17 14 1 0 18 6 1 0 19 18 2 0 20 11 1 0 21 11 2 0 22 23 2 0 23 21 1 0 24 20 2 0 25 16 2 0 26 9 2 0 27 28 2 0 28 26 1 0 2 4 1 0 22 24 1 0 8 13 2 0 15 17 1 0 25 27 1 0 M END > 92596 > J. Med. Chem. 45(5)-2002 999-1001 > p38a > 4.8239 $$$$ SciTegic07090714182D 28 31 0 0 0 0 999 V2000 -5.4984 5.5497 0.0000 C 0 0 -6.2484 4.2507 0.0000 C 0 0 -4.0312 5.2378 0.0000 N 0 0 -3.8933 3.7570 0.0000 C 0 0 -5.2447 3.1359 0.0000 N 0 0 2.5973 -1.5031 0.0000 S 0 0 -2.5951 3.0039 0.0000 S 0 0 1.2990 -0.7500 0.0000 C 0 0 -6.1088 6.9207 0.0000 C 0 0 -7.7410 4.0938 0.0000 C 0 0 2.5956 -2.7031 0.0000 O 0 0 -10.6886 3.5534 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -2.5973 1.5031 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.6375 -0.9049 0.0000 C 0 0 -10.1833 4.9657 0.0000 C 0 0 -9.7181 2.4096 0.0000 C 0 0 -8.7076 5.2343 0.0000 C 0 0 -8.2423 2.6782 0.0000 C 0 0 -7.5799 7.1875 0.0000 C 0 0 -5.1336 8.0627 0.0000 C 0 0 -5.6389 9.4750 0.0000 C 0 0 -8.0851 8.5999 0.0000 C 0 0 -7.1146 9.7436 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 3 2 0 5 2 1 0 6 8 1 0 7 4 1 0 8 14 1 0 9 1 1 0 10 2 1 0 11 6 2 0 12 21 2 0 13 17 1 0 14 18 2 0 15 7 1 0 16 15 1 0 17 16 2 0 18 16 1 0 19 6 1 0 20 22 2 0 21 23 1 0 22 10 1 0 23 10 2 0 24 9 1 0 25 9 2 0 26 25 1 0 27 24 2 0 28 26 2 0 5 4 1 0 28 27 1 0 12 20 1 0 8 13 2 0 M END > 106411 > J. Med. Chem. 45(21)-2002 4695-4705 > p38a > 4.9208 $$$$ SciTegic07090714182D 28 30 0 0 0 0 999 V2000 -9.0835 9.7649 0.0000 C 0 0 -9.8255 12.0540 0.0000 N 0 0 -7.8670 10.6205 0.0000 C 0 0 -10.2940 10.6290 0.0000 N 0 0 -8.3255 12.0487 0.0000 C 0 0 -9.0857 8.2641 0.0000 N 0 0 -7.7875 7.5110 0.0000 C 0 0 -7.4406 13.2577 0.0000 C 0 0 -7.7897 6.0102 0.0000 N 0 0 -6.7472 8.1092 0.0000 O 0 0 1.2990 -0.7500 0.0000 N 0 0 -2.5973 1.5031 0.0000 S 0 0 -6.4915 5.2571 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 -11.4344 10.2554 0.0000 C 0 0 -6.4915 3.7571 0.0000 C 0 0 -5.1924 6.0070 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -3.8934 5.2570 0.0000 C 0 0 -5.1925 3.0070 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -6.2476 13.1289 0.0000 C 0 0 -7.9252 14.3555 0.0000 C 0 0 -6.7324 14.2264 0.0000 C 0 0 2 4 1 0 3 1 2 0 4 1 1 0 5 3 1 0 6 1 1 0 7 6 1 0 8 5 1 0 9 7 1 0 10 7 2 0 11 24 2 0 12 15 1 0 13 9 1 0 14 12 1 0 15 16 1 0 16 22 1 0 17 4 1 0 18 13 2 0 19 13 1 0 20 14 1 0 21 14 2 0 22 19 2 0 23 18 1 0 24 21 1 0 25 20 2 0 26 8 1 0 27 8 1 0 28 8 1 0 5 2 2 0 16 23 2 0 11 25 1 0 M END > 3534 > Bioorg. Med. Chem. Lett. 12(12)-2002 1559-1562 > p38a > 6.2336 $$$$ SciTegic07090714182D 28 31 0 0 0 0 999 V2000 -1.0028 1.5132 0.0000 C 0 0 -0.9971 3.0138 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 -2.2935 3.7700 0.0000 C 0 0 0.3042 3.7615 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -2.2901 5.2700 0.0000 C 0 0 -3.5944 3.0231 0.0000 C 0 0 0.3074 4.9615 0.0000 O 0 0 -3.6168 -1.4950 0.0000 C 0 0 1.3420 3.1590 0.0000 N 0 0 -1.2494 5.8675 0.0000 F 0 0 -3.5973 1.8231 0.0000 F 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.8881 5.2761 0.0000 C 0 0 -4.8917 3.7761 0.0000 C 0 0 -3.5873 6.0231 0.0000 C 0 0 -4.9144 -0.7421 0.0000 C 0 0 -3.6204 -2.9950 0.0000 C 0 0 -4.9211 -3.7421 0.0000 C 0 0 -6.2151 -1.4892 0.0000 C 0 0 -6.2185 -2.9892 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 1 2 0 6 8 2 0 7 3 1 0 8 5 1 0 9 4 1 0 10 2 1 0 11 2 1 0 12 7 2 0 13 10 2 0 14 10 1 0 15 11 2 0 16 8 1 0 17 11 1 0 18 13 1 0 19 14 1 0 20 9 1 0 21 22 1 0 22 14 2 0 23 13 1 0 24 16 2 0 25 16 1 0 26 25 2 0 27 24 1 0 28 26 1 0 6 4 1 0 9 12 1 0 21 23 2 0 28 27 2 0 M END > 102630 > Bioorg. Med. Chem. Lett. 13(06)-2003 1191-1194 > p38a > 6.2924 $$$$ SciTegic07090714182D 28 31 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 -0.0303 -8.9091 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 -2.2783 -10.8959 0.0000 O 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 5.4388 4.6145 0.0000 F 0 0 1.6137 -3.9759 0.0000 C 0 0 1.0922 -7.9130 0.0000 C 0 0 0.2679 -10.3792 0.0000 C 0 0 -1.4527 -8.4325 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.5766 -9.4258 0.0000 C 0 0 -0.8561 -11.3726 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.9143 -5.4464 0.0000 C 0 0 0.7917 -6.4425 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 1 0 5 1 2 0 6 2 1 0 7 18 1 0 8 3 1 0 9 22 1 0 10 23 1 0 11 6 2 0 12 6 1 0 13 14 1 0 14 12 2 0 15 11 1 0 16 13 1 0 17 4 1 0 18 28 1 0 19 7 1 0 20 7 1 0 21 25 1 0 22 26 2 0 23 20 1 0 24 19 1 0 25 8 2 0 26 8 1 0 27 17 1 0 28 27 1 0 4 3 1 0 15 13 2 0 21 9 2 0 24 10 1 0 M END > 33039 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 6.3188 $$$$ SciTegic07090714182D 28 31 0 0 0 0 999 V2000 1.9599 -4.5332 0.0000 C 0 0 0.4603 -4.4978 0.0000 N 0 0 0.0306 -3.0607 0.0000 N 0 0 2.4570 -3.1180 0.0000 C 0 0 1.2641 -2.2299 0.0000 C 0 0 2.8143 -5.7640 0.0000 N 0 0 4.3100 -5.6403 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 5.1658 -6.8732 0.0000 N 0 0 -0.4502 -5.6908 0.0000 C 0 0 4.8219 -4.5549 0.0000 O 0 0 -1.2990 0.7500 0.0000 O 0 0 6.6615 -6.7494 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.3239 -0.1258 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0209 -7.1097 0.0000 C 0 0 -1.9199 -5.3825 0.0000 C 0 0 7.5187 -7.9804 0.0000 C 0 0 7.2992 -5.3916 0.0000 C 0 0 -2.9171 -6.5030 0.0000 C 0 0 -0.9763 -8.2302 0.0000 C 0 0 8.7938 -5.2649 0.0000 C 0 0 9.0134 -7.8536 0.0000 C 0 0 -2.4453 -7.9269 0.0000 C 0 0 9.6509 -6.4959 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 4 1 0 6 1 1 0 7 6 1 0 8 5 1 0 9 7 1 0 10 2 1 0 11 7 2 0 12 18 1 0 13 9 1 0 14 8 1 0 15 8 1 0 16 8 1 0 17 14 1 0 18 15 1 0 19 10 2 0 20 10 1 0 21 13 2 0 22 13 1 0 23 20 2 0 24 19 1 0 25 22 2 0 26 21 1 0 27 23 1 0 28 25 1 0 5 3 2 0 12 17 1 0 27 24 2 0 28 26 2 0 M END > 95592 > J. Med. Chem. 45(14)-2002 2994-3008 > p38a > 6.5528 $$$$ SciTegic07090714182D 28 31 0 0 0 0 999 V2000 -1.2964 -1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 N 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2919 -2.9980 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 3.8911 1.5017 0.0000 S 0 0 2.5929 -0.7486 0.0000 C 0 0 3.8890 3.0026 0.0000 C 0 0 5.1854 3.7571 0.0000 C 0 0 5.1802 5.2571 0.0000 C 0 0 -2.5891 -3.7515 0.0000 C 0 0 0.0089 -3.7449 0.0000 C 0 0 -3.6486 -1.3517 0.0000 O 0 0 2.5873 3.7482 0.0000 C 0 0 3.8786 6.0026 0.0000 C 0 0 6.2267 3.1608 0.0000 N 0 0 -3.6299 -3.1542 0.0000 Cl 0 0 1.0467 -3.1424 0.0000 Cl 0 0 2.5821 5.2482 0.0000 C 0 0 3.8744 7.2026 0.0000 F 0 0 -1.2844 -5.9982 0.0000 C 0 0 -2.5853 -5.2515 0.0000 C 0 0 0.0127 -5.2449 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 6 1 0 5 3 1 0 6 1 1 0 7 1 1 0 8 4 2 0 9 12 1 0 10 2 1 0 11 9 1 0 12 10 2 0 13 11 1 0 14 13 1 0 15 14 2 0 16 7 2 0 17 7 1 0 18 6 2 0 19 13 2 0 20 24 2 0 21 14 1 0 22 16 1 0 23 17 1 0 24 19 1 0 25 20 1 0 26 28 1 0 27 16 1 0 28 17 2 0 26 27 2 0 8 3 1 0 9 5 2 0 20 15 1 0 M END > 89261 > J. Med. Chem. 44(21)-2001 3417-3423 > p38a > 6.6580 $$$$ SciTegic07090714182D 28 30 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -0.0126 5.9981 0.0000 C 0 0 -0.0156 7.4989 0.0000 N 0 0 2.5972 1.5031 0.0000 N 0 0 -1.3164 8.2475 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 -1.4594 9.7279 0.0000 N 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 -0.7500 0.0000 N 0 0 -2.6657 7.6218 0.0000 C 0 0 2.5988 -1.5004 0.0000 C 0 0 1.2883 5.2495 0.0000 C 0 0 3.6380 -2.1004 0.0000 N 0 0 -0.0031 -3.0008 0.0000 N 0 0 1.2934 3.7495 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.9277 10.0347 0.0000 O 0 0 -3.6732 8.7331 0.0000 C 0 0 3.8915 3.7585 0.0000 C 0 0 -1.0508 5.3963 0.0000 O 0 0 2.5847 6.0040 0.0000 C 0 0 3.8863 5.2585 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 4.9328 3.1621 0.0000 C 0 0 -1.3064 -4.9494 0.0000 C 0 0 -2.3421 -3.1476 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 14 1 0 5 4 1 0 6 2 1 0 7 5 1 0 8 6 1 0 9 7 2 0 10 2 2 0 11 3 1 0 12 7 1 0 13 1 1 0 14 17 1 0 15 13 3 0 16 3 1 0 17 8 2 0 18 11 2 0 19 9 1 0 20 12 2 0 21 8 1 0 22 4 2 0 23 24 1 0 24 21 2 0 25 16 1 0 26 21 1 0 27 25 1 0 28 25 1 0 18 10 1 0 23 14 2 0 19 20 1 0 M END > 162198 > J. Med. Chem. 48(20)-2005 6261-6270 > p38a > 9.3872 $$$$ SciTegic07090714182D 29 32 0 0 0 0 999 V2000 4.9531 -1.9978 0.0000 N 0 0 3.9511 -0.8815 0.0000 C 0 0 2.5987 -1.5004 0.0000 C 0 0 2.7343 -2.9815 0.0000 N 0 0 4.2010 -3.2956 0.0000 C 0 0 4.2568 0.5878 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 3.2235 1.6679 0.0000 C 0 0 5.7171 0.9385 0.0000 C 0 0 5.1019 3.4627 0.0000 C 0 0 1.6137 -3.9759 0.0000 C 0 0 6.1382 2.3782 0.0000 C 0 0 3.6446 3.1076 0.0000 C 0 0 1.0922 -7.9130 0.0000 N 0 0 5.4388 4.6145 0.0000 F 0 0 1.9143 -5.4464 0.0000 C 0 0 0.2702 -10.3796 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.7917 -6.4425 0.0000 C 0 0 -0.0303 -8.9091 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -0.8503 -11.3769 0.0000 C 0 0 1.6941 -10.8515 0.0000 C 0 0 1.9974 -12.3205 0.0000 C 0 0 -0.5470 -12.8459 0.0000 C 0 0 0.8769 -13.3177 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 5 1 0 5 1 2 0 6 2 1 0 7 3 1 0 8 20 1 0 9 6 2 0 10 6 1 0 11 13 1 0 12 4 1 0 13 10 2 0 14 9 1 0 15 21 1 0 16 11 1 0 17 12 1 0 18 22 1 0 19 23 1 0 20 24 2 0 21 17 1 0 22 15 1 0 23 7 2 0 24 7 1 0 25 18 2 0 26 18 1 0 27 26 2 0 28 25 1 0 29 27 1 0 4 3 1 0 14 11 2 0 19 8 2 0 28 29 2 0 M END > 33041 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 7.1549 $$$$ SciTegic07090714182D 30 33 0 0 0 0 999 V2000 5.1769 -10.5118 0.0000 C 0 0 5.3149 -11.9926 0.0000 C 0 0 6.7821 -12.3044 0.0000 N 0 0 7.5320 -11.0054 0.0000 N 0 0 6.5283 -9.8907 0.0000 C 0 0 3.8787 -9.7587 0.0000 C 0 0 7.3925 -13.6754 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 1.2990 -0.7500 0.0000 N 0 0 4.4183 -12.7903 0.0000 N 0 0 2.8385 -10.3569 0.0000 O 0 0 -1.2990 0.7500 0.0000 O 0 0 6.6065 -14.9472 0.0000 C 0 0 8.8937 -13.7148 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 8.8174 -16.3118 0.0000 C 0 0 9.6052 -15.0353 0.0000 C 0 0 7.3181 -16.2677 0.0000 C 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 9.3866 -17.3682 0.0000 F 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 5 2 0 5 1 1 0 6 1 1 0 7 3 1 0 8 6 1 0 9 24 1 0 10 2 1 0 11 6 2 0 12 28 1 0 13 7 2 0 14 7 1 0 15 8 2 0 16 8 1 0 17 18 1 0 18 14 2 0 19 13 1 0 20 16 2 0 21 15 1 0 22 20 1 0 23 17 1 0 24 27 1 0 25 9 1 0 26 9 1 0 27 30 1 0 28 26 1 0 29 25 1 0 30 22 1 0 3 4 1 0 22 21 2 0 17 19 2 0 12 29 1 0 M END > 167999 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 4.6517 $$$$ SciTegic07090714182D 30 33 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 3.3372 -5.2929 0.0000 N 0 0 1.8372 -5.2877 0.0000 N 0 0 2.5973 -1.5031 0.0000 C 0 0 1.3786 -3.8595 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.2151 -6.5101 0.0000 C 0 0 -2.6078 5.9988 0.0000 N 0 0 4.9460 -3.4943 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 1.2990 0.7500 0.0000 C 0 0 -5.2112 7.4898 0.0000 O 0 0 5.7096 -6.4704 0.0000 C 0 0 3.4940 -7.8274 0.0000 C 0 0 5.7769 -9.0677 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 6.4930 -7.7496 0.0000 C 0 0 4.2774 -9.1065 0.0000 C 0 0 6.4037 -10.0910 0.0000 F 0 0 -1.3070 5.2502 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -2.6131 7.4988 0.0000 C 0 0 -3.9044 5.2443 0.0000 C 0 0 -1.3039 3.7494 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -5.2060 5.9898 0.0000 C 0 0 -3.9148 8.2443 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 6 2 0 5 1 1 0 6 1 1 0 7 5 1 0 8 3 1 0 9 21 1 0 10 2 1 0 11 5 2 0 12 7 2 0 13 27 1 0 14 8 1 0 15 8 2 0 16 19 2 0 17 12 1 0 18 14 2 0 19 15 1 0 20 16 1 0 21 25 1 0 22 7 1 0 23 9 1 0 24 9 1 0 25 29 1 0 26 22 2 0 27 24 1 0 28 23 1 0 29 17 1 0 30 26 1 0 3 4 1 0 30 17 2 0 16 18 1 0 13 28 1 0 M END > 167998 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 5.7595 $$$$ SciTegic07090714182D 30 33 0 0 0 0 999 V2000 6.4963 -8.2565 0.0000 C 0 0 6.6393 -9.7368 0.0000 C 0 0 8.1076 -10.0436 0.0000 N 0 0 8.8531 -8.7420 0.0000 N 0 0 5.1955 -7.5079 0.0000 C 0 0 7.8455 -7.6308 0.0000 C 0 0 5.1924 -6.0070 0.0000 C 0 0 8.7227 -11.4125 0.0000 C 0 0 1.2990 -0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 N 0 0 5.7455 -10.5376 0.0000 N 0 0 4.1573 -8.1097 0.0000 O 0 0 3.8934 -5.2570 0.0000 C 0 0 7.9411 -12.6869 0.0000 C 0 0 10.2240 -11.4467 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 10.1566 -14.0439 0.0000 C 0 0 10.9401 -12.7648 0.0000 C 0 0 8.6571 -14.0050 0.0000 C 0 0 10.7295 -15.0984 0.0000 F 0 0 2.5951 -3.0039 0.0000 C 0 0 6.4915 -5.2571 0.0000 C 0 0 -2.3383 1.3500 0.0000 C 0 0 6.4915 -3.7571 0.0000 C 0 0 5.1925 -3.0070 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 6 2 0 5 1 1 0 6 1 1 0 7 5 1 0 8 3 1 0 9 16 1 0 10 19 1 0 11 2 1 0 12 5 2 0 13 7 2 0 14 8 1 0 15 8 2 0 16 26 1 0 17 9 1 0 18 9 1 0 19 18 1 0 20 17 1 0 21 13 1 0 22 23 2 0 23 15 1 0 24 14 2 0 25 22 1 0 26 21 1 0 27 7 1 0 28 10 1 0 29 27 2 0 30 29 1 0 3 4 1 0 30 21 2 0 22 24 1 0 10 20 1 0 M END > 167989 > J. Med. Chem. 49(5)-2006 1562-1575 > p38a > 5.7852 $$$$ SciTegic07090714182D 30 34 0 0 0 0 999 V2000 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 2.1855 -2.6254 0.0000 C 0 0 2.1749 2.6315 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 4.1277 -4.3539 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 7.0761 0.2776 0.0000 N 0 0 3.6552 -2.9294 0.0000 C 0 0 5.0663 -7.2034 0.0000 O 0 0 1.2517 3.8078 0.0000 C 0 0 3.6621 2.8384 0.0000 C 0 0 3.2965 5.4106 0.0000 C 0 0 4.2218 4.2301 0.0000 C 0 0 1.8114 5.1995 0.0000 C 0 0 3.7442 6.5239 0.0000 F 0 0 -1.0028 -1.5132 0.0000 C 0 0 5.5962 -4.6599 0.0000 C 0 0 3.1285 -5.4728 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 3.5978 -6.8975 0.0000 C 0 0 6.0655 -6.0846 0.0000 C 0 0 4.9397 -1.2009 0.0000 C 0 0 4.7275 1.3885 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 1 0 5 1 1 0 6 1 1 0 7 2 1 0 8 4 2 0 9 12 1 0 10 3 1 0 11 25 2 0 12 6 1 0 13 26 1 0 14 7 1 0 15 7 2 0 16 17 2 0 17 15 1 0 18 14 2 0 19 16 1 0 20 5 2 0 21 9 1 0 22 9 1 0 23 30 2 0 24 28 2 0 25 29 1 0 26 22 1 0 27 21 1 0 28 10 1 0 29 10 2 0 30 20 1 0 4 2 1 0 23 8 1 0 11 24 1 0 13 27 1 0 18 16 1 0 M END > 114475 > J. Med. Chem. 46(22)-2003 4702-4713 > p38a > 6.7328 $$$$ SciTegic07090714182D 30 34 0 0 0 0 999 V2000 4.0896 0.0290 0.0000 C 0 0 6.3129 -0.8859 0.0000 C 0 0 4.8568 -1.2462 0.0000 N 0 0 7.4608 -1.8526 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 6.4203 0.6103 0.0000 N 0 0 5.0305 1.1747 0.0000 C 0 0 9.8940 -3.6019 0.0000 N 0 0 8.5260 -4.2171 0.0000 C 0 0 10.0453 -2.1096 0.0000 C 0 0 1.7138 -1.2033 0.0000 O 0 0 7.3092 -3.3399 0.0000 C 0 0 8.8285 -1.2324 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 4.6611 2.6292 0.0000 C 0 0 4.1609 5.5838 0.0000 N 0 0 11.1397 -1.6174 0.0000 N 0 0 8.4050 -5.4110 0.0000 N 0 0 8.9476 -0.0383 0.0000 F 0 0 6.2146 -3.8318 0.0000 F 0 0 -1.0028 -1.5132 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 5.5676 5.0630 0.0000 C 0 0 3.0065 4.6259 0.0000 C 0 0 3.2589 3.1473 0.0000 C 0 0 5.8200 3.5844 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 2 1 0 5 1 1 0 6 7 1 0 7 1 2 0 8 10 1 0 9 12 1 0 10 13 2 0 11 5 1 0 12 4 2 0 13 4 1 0 14 5 2 0 15 11 1 0 16 14 1 0 17 7 1 0 18 25 2 0 19 10 1 0 20 9 1 0 21 13 1 0 22 12 1 0 23 15 1 0 24 16 1 0 25 28 1 0 26 27 2 0 27 17 1 0 28 17 2 0 29 24 2 0 30 23 2 0 6 2 1 0 15 16 2 0 18 26 1 0 29 30 1 0 8 9 2 0 M END > 4692 > Bioorg. Med. Chem. Lett. 12(16)-2002 2109-2112 > p38a > 8.3010 $$$$ SciTegic07090714182D 30 33 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -0.0126 5.9981 0.0000 C 0 0 -0.0156 7.4989 0.0000 N 0 0 2.5972 1.5031 0.0000 N 0 0 -1.3164 8.2475 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 -1.4594 9.7279 0.0000 N 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 -0.7500 0.0000 N 0 0 -2.6657 7.6218 0.0000 C 0 0 2.5988 -1.5004 0.0000 C 0 0 1.2883 5.2495 0.0000 C 0 0 -0.0031 -3.0008 0.0000 N 0 0 3.6380 -2.1004 0.0000 N 0 0 1.2934 3.7495 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.9277 10.0347 0.0000 O 0 0 -3.6732 8.7331 0.0000 C 0 0 3.8915 3.7585 0.0000 C 0 0 -1.0508 5.3963 0.0000 O 0 0 2.5847 6.0040 0.0000 C 0 0 3.8863 5.2585 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 4.9328 3.1621 0.0000 C 0 0 -1.4469 -5.2298 0.0000 C 0 0 -2.6531 -3.1237 0.0000 C 0 0 -2.9152 -5.5365 0.0000 C 0 0 -3.6607 -4.2349 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 14 1 0 5 4 1 0 6 2 1 0 7 5 1 0 8 6 1 0 9 7 2 0 10 2 2 0 11 3 1 0 12 7 1 0 13 1 1 0 14 17 1 0 15 3 1 0 16 13 3 0 17 8 2 0 18 11 2 0 19 9 1 0 20 12 2 0 21 8 1 0 22 4 2 0 23 24 1 0 24 21 2 0 25 15 1 0 26 21 1 0 27 25 1 0 28 25 1 0 29 27 1 0 30 28 1 0 10 18 1 0 30 29 1 0 23 14 2 0 19 20 1 0 M END > 162199 > J. Med. Chem. 48(20)-2005 6261-6270 > p38a > 8.7959 $$$$ SciTegic07090714182D 31 35 0 0 0 0 999 V2000 -1.2919 2.9980 0.0000 C 0 0 -2.0364 5.2864 0.0000 N 0 0 -2.5034 3.8610 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -0.0764 3.8550 0.0000 N 0 0 -0.5364 5.2827 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -3.9291 3.3923 0.0000 C 0 0 5.0163 4.8945 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 7.2591 6.8871 0.0000 O 0 0 -4.3491 1.9577 0.0000 C 0 0 -4.9620 4.4825 0.0000 C 0 0 2.4688 4.3752 0.0000 C 0 0 1.3448 3.3807 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -6.8421 2.6893 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -6.4197 4.1286 0.0000 C 0 0 -5.8068 1.6039 0.0000 C 0 0 3.8923 3.8999 0.0000 C 0 0 -8.0082 2.4062 0.0000 F 0 0 6.4399 4.4216 0.0000 C 0 0 4.7143 6.3638 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 7.5612 5.4178 0.0000 C 0 0 5.8356 7.3601 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 3 1 0 3 1 2 0 4 1 1 0 5 1 1 0 6 5 1 0 7 4 2 0 8 3 1 0 9 22 1 0 10 19 1 0 11 7 1 0 12 28 1 0 13 8 2 0 14 8 1 0 15 16 1 0 16 5 1 0 17 4 1 0 18 20 1 0 19 17 2 0 20 14 2 0 21 13 1 0 22 15 1 0 23 18 1 0 24 9 1 0 25 9 1 0 26 7 1 0 27 24 1 0 28 25 1 0 29 11 1 0 30 26 2 0 31 30 1 0 2 6 2 0 11 10 2 0 21 18 2 0 31 29 2 0 27 12 1 0 M END > 33071 > J. Med. Chem. 39(20)-1996 3929-3937 > p38a > 5.0458 $$$$ SciTegic07090714182D 31 35 0 0 1 0 999 V2000 0.9876 1.5922 0.0000 C 0 0 2.1968 0.6852 0.0000 C 0 0 -0.2419 0.7054 0.0000 N 0 0 1.7333 -0.7256 0.0000 C 0 0 0.2217 -0.7054 0.0000 N 0 0 1.0015 3.0929 0.0000 C 0 0 -0.2217 3.9519 0.0000 N 0 0 -0.0880 5.4460 0.0000 C 0 0 3.6284 1.1358 0.0000 C 0 0 -1.3139 6.3118 0.0000 N 0 0 2.4305 -1.7022 0.0000 O 0 0 1.2727 6.0772 0.0000 N 0 0 -1.1780 7.8064 0.0000 C 0 0 2 0 0 0 -1.7333 0.7457 0.0000 C 0 0 -0.9876 -1.5720 0.0000 C 0 0 2.3660 3.7203 0.0000 C 0 0 4.7992 0.2058 0.0000 C 0 0 3.8440 2.6219 0.0000 C 0 0 -2.4039 8.6723 0.0000 C 0 0 -2.1968 -0.7054 0.0000 C 0 0 2.4998 5.2144 0.0000 C 0 0 6.4140 2.2411 0.0000 C 0 0 5.2389 3.1734 0.0000 C 0 0 6.1942 0.7573 0.0000 C 0 0 7.5299 2.6823 0.0000 F 0 0 -0.0885 8.3095 0.0000 C 0 0 -2.2702 10.1663 0.0000 C 0 0 -3.7647 8.0411 0.0000 C 0 0 -4.9917 8.9040 0.0000 C 0 0 -3.4972 11.0292 0.0000 C 0 0 -4.8579 10.3980 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 3 1 0 6 1 1 0 7 6 2 0 8 7 1 0 9 2 1 0 10 8 1 0 11 4 2 0 12 21 1 0 13 10 1 0 14 3 1 0 15 5 1 0 16 6 1 0 17 9 1 0 18 9 2 0 19 13 1 0 20 14 1 0 21 16 2 0 22 23 2 0 23 18 1 0 24 17 2 0 25 22 1 0 13 26 1 6 27 19 2 0 28 19 1 0 29 28 2 0 30 27 1 0 31 29 1 0 4 5 1 0 15 20 1 0 12 8 2 0 24 22 1 0 31 30 2 0 M END > 129593 > J. Med. Chem. 47(11)-2004 2724-2727 > p38a > 5.0969 $$$$ SciTegic07090714182D 31 34 0 0 1 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 0.0000 -1.5000 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 2.5973 -1.5031 0.0000 N 0 0 -0.0031 3.0008 0.0000 N 0 0 -1.3039 3.7494 0.0000 C 0 0 -5.2008 2.9882 0.0000 C 0 0 -3.9021 3.7404 0.0000 C 0 0 -2.6005 2.9949 0.0000 C 0 0 -2.6003 -1.4978 0.0000 N 0 0 -1.3092 5.2494 0.0000 C 0 0 -5.4979 1.0528 0.0000 N 0 0 -6.2412 3.5861 0.0000 O 0 0 -3.9073 5.2404 0.0000 C 0 0 -2.6108 5.9949 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 -5.1987 1.7882 0.0000 N 0 0 -3.8990 -0.7455 0.0000 C 0 0 2 0 0 0 -5.2525 -1.3618 0.0000 C 0 0 3.6375 -0.9049 0.0000 C 0 0 -6.2524 -0.2436 0.0000 C 0 0 -4.0317 0.7358 0.0000 C 0 0 -0.2721 5.8530 0.0000 C 0 0 3.8915 -3.7585 0.0000 C 0 0 1.2935 -3.7495 0.0000 C 0 0 1.2883 -5.2495 0.0000 C 0 0 3.8864 -5.2585 0.0000 C 0 0 2.5847 -6.0040 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 5 2 0 7 1 1 0 8 4 1 0 9 8 1 0 10 11 1 0 11 12 2 0 12 9 1 0 13 5 1 0 14 9 2 0 15 25 1 0 16 10 2 0 17 18 2 0 18 14 1 0 19 7 1 0 20 10 1 0 21 13 1 6 22 21 1 0 23 7 1 0 24 22 1 0 25 21 1 0 26 14 1 0 27 19 1 0 28 19 1 0 29 28 1 0 30 27 1 0 31 29 1 0 6 4 1 0 31 30 1 0 24 15 1 0 17 11 1 0 M END > 134472 > J. Med. Chem. 47(25)-2004 6283-6291 > p38a > 6.6021 $$$$ SciTegic07090714182D 31 34 0 0 0 0 999 V2000 -0.0031 3.0008 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 2.5987 -1.5004 0.0000 N 0 0 -2.6061 7.5003 0.0000 C 0 0 -1.3039 3.7494 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -2.6061 6.0003 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 1.0351 3.6026 0.0000 O 0 0 -3.9074 8.2480 0.0000 C 0 0 -9.1056 8.2433 0.0000 N 0 0 5.1945 -3.0045 0.0000 O 0 0 -0.0080 7.5003 0.0000 C 0 0 -5.2061 7.4957 0.0000 O 0 0 -0.0080 6.0003 0.0000 C 0 0 -1.3071 9.4503 0.0000 Cl 0 0 -2.3383 -1.3500 0.0000 F 0 0 -6.5074 8.2434 0.0000 C 0 0 3.8991 -0.7525 0.0000 C 0 0 2.5965 -3.0004 0.0000 C 0 0 -7.8065 7.4934 0.0000 C 0 0 -9.1056 9.7433 0.0000 C 0 0 3.8943 -3.7525 0.0000 C 0 0 5.1969 -1.5045 0.0000 C 0 0 -6.5075 9.7434 0.0000 C 0 0 -7.8066 10.4934 0.0000 C 0 0 2 7 2 0 3 1 1 0 4 2 1 0 5 11 2 0 6 1 1 0 7 3 1 0 8 13 2 0 9 18 2 0 10 6 1 0 11 10 1 0 12 3 2 0 13 12 1 0 14 1 2 0 15 5 1 0 16 26 2 0 17 28 1 0 18 20 1 0 19 15 1 0 20 10 2 0 21 9 1 0 22 13 1 0 23 19 1 0 24 4 1 0 25 4 1 0 26 23 1 0 27 31 2 0 28 25 1 0 29 24 1 0 30 23 2 0 31 30 1 0 2 8 1 0 5 9 1 0 29 17 1 0 27 16 1 0 M END > 146928 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 7.1871 $$$$ SciTegic07090714182D 31 35 0 0 1 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 0.2917 0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 2.1749 2.6315 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 3.6113 3.0471 0.0000 N 0 0 3.9698 4.5036 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 5.4104 4.9246 0.0000 N 0 0 2.8877 5.5424 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 5.7670 6.3824 0.0000 C 0 0 1 0 0 0 1.0885 3.6681 0.0000 C 0 0 7.2076 6.8034 0.0000 C 0 0 -3.3560 -1.3452 0.0000 N 0 0 1.4470 5.1246 0.0000 C 0 0 4.8999 7.2119 0.0000 C 0 0 4.9234 1.2700 0.0000 C 0 0 4.7453 -1.3220 0.0000 C 0 0 7.5662 8.2599 0.0000 C 0 0 8.2898 5.7647 0.0000 C 0 0 9.7305 6.1825 0.0000 C 0 0 9.0068 8.6778 0.0000 C 0 0 6.2418 -1.4248 0.0000 C 0 0 6.4199 1.1671 0.0000 C 0 0 10.0890 7.6390 0.0000 C 0 0 7.0791 -0.1803 0.0000 C 0 0 2 1 2 0 3 4 1 0 4 1 1 0 5 2 1 0 6 1 1 0 7 3 1 0 8 4 1 0 9 7 2 0 10 9 1 0 11 12 1 0 12 6 2 0 13 10 1 0 14 20 1 0 15 5 1 0 16 13 1 0 17 7 1 0 18 16 1 0 19 12 1 0 20 17 2 0 16 21 1 6 22 15 1 0 23 15 2 0 24 18 1 0 25 18 2 0 26 25 1 0 27 24 2 0 28 23 1 0 29 22 2 0 30 26 2 0 31 28 2 0 3 5 2 0 8 11 2 0 14 10 2 0 31 29 1 0 30 27 1 0 M END > 100420 > Bioorg. Med. Chem. Lett. 13(3)-2003 347-350 > p38a > 7.4318 $$$$ SciTegic07090714182D 32 34 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 -0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 2.5987 1.5004 0.0000 N 0 0 -2.5973 1.5031 0.0000 N 0 0 -0.0031 -3.0008 0.0000 N 0 0 -2.5951 3.0039 0.0000 C 0 0 0.0125 5.9981 0.0000 C 0 0 -1.2883 5.2495 0.0000 C 0 0 -1.2935 3.7495 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 -3.8915 3.7585 0.0000 C 0 0 5.1945 3.0046 0.0000 N 0 0 1.0507 5.3963 0.0000 O 0 0 -2.5848 6.0040 0.0000 C 0 0 -1.3070 -5.2502 0.0000 C 0 0 0.0155 7.4989 0.0000 N 0 0 -3.8864 5.2585 0.0000 C 0 0 3.8991 0.7525 0.0000 C 0 0 2.5964 3.0004 0.0000 C 0 0 1.3163 8.2475 0.0000 O 0 0 1.0351 -3.6026 0.0000 C 0 0 3.8943 3.7525 0.0000 C 0 0 5.1969 1.5046 0.0000 C 0 0 -4.9329 3.1621 0.0000 C 0 0 -2.3471 -5.8487 0.0000 C 0 0 -1.3089 -6.4502 0.0000 C 0 0 -0.2688 -5.8520 0.0000 C 0 0 1.3188 9.4475 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 5 2 0 7 2 1 0 8 6 1 0 9 3 1 0 10 8 1 0 11 12 1 0 12 13 2 0 13 10 1 0 14 9 1 0 15 10 2 0 16 26 1 0 17 11 2 0 18 21 2 0 19 14 1 0 20 11 1 0 21 15 1 0 22 7 1 0 23 7 1 0 24 20 1 0 25 9 1 0 26 23 1 0 27 22 1 0 28 15 1 0 29 19 1 0 30 19 1 0 31 19 1 0 32 24 1 0 6 4 1 0 16 27 1 0 12 18 1 0 M END > 134482 > J. Med. Chem. 47(25)-2004 6283-6291 > p38a > 7.7447 $$$$ SciTegic07090714182D 33 37 0 0 0 0 999 V2000 -4.9153 0.7255 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 -8.8197 1.4467 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 -6.2216 1.4644 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 -10.1142 0.6875 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -3.6217 1.4865 0.0000 N 0 0 -7.5156 0.7056 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -8.8299 2.9467 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -6.2319 2.9644 0.0000 C 0 0 -7.5360 3.7055 0.0000 C 0 0 -4.9050 -0.4745 0.0000 O 0 0 2.1812 2.6271 0.0000 C 0 0 5.0484 7.2137 0.0000 N 0 0 -1.0028 -1.5132 0.0000 C 0 0 -12.7045 -0.8261 0.0000 O 0 0 -2.3155 -0.7475 0.0000 C 0 0 -7.5442 4.9055 0.0000 F 0 0 3.6500 2.9355 0.0000 C 0 0 -10.1065 -0.8125 0.0000 C 0 0 -11.4173 1.4307 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 6.0509 6.0979 0.0000 C 0 0 3.5808 6.9034 0.0000 C 0 0 -11.4016 -1.5693 0.0000 C 0 0 -12.7124 0.6739 0.0000 C 0 0 5.5858 4.6718 0.0000 C 0 0 3.1158 5.4773 0.0000 C 0 0 2 11 1 0 3 10 1 0 4 13 2 0 5 1 1 0 6 4 1 0 7 3 1 0 8 6 2 0 9 1 1 0 10 5 2 0 11 20 2 0 12 16 1 0 13 14 1 0 14 9 1 0 15 5 1 0 16 15 2 0 17 1 2 0 18 6 1 0 19 29 1 0 20 22 1 0 21 31 1 0 22 14 2 0 23 16 1 0 24 18 1 0 25 7 1 0 26 7 1 0 27 24 1 0 28 32 1 0 29 33 2 0 30 25 1 0 31 26 1 0 32 27 2 0 33 27 1 0 3 12 2 0 4 11 1 0 2 8 1 0 30 21 1 0 28 19 2 0 M END > 146935 > J. Med. Chem. 48(2)-2005 414-426 > p38a > 6.2007 $$$$