SciTegic07100714482D 20 21 0 0 1 0 999 V2000 3.8933 -3.7570 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 2 0 0 0 3.8916 -4.9570 0.0000 O 0 0 2.5973 -1.5031 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 1.5548 -3.6021 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 4.9336 -3.1588 0.0000 O 0 0 -2.5951 3.0039 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 -3.8934 5.2570 0.0000 C 0 0 -5.1925 3.0070 0.0000 C 0 0 -5.1924 6.0070 0.0000 C 0 0 -6.4915 3.7571 0.0000 C 0 0 -6.4915 5.2571 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 8 1 0 6 4 1 0 2 7 1 1 8 14 1 0 9 1 1 0 10 5 1 0 11 6 2 0 12 6 1 0 13 11 1 0 14 12 2 0 15 10 1 0 16 15 1 0 17 15 2 0 18 16 2 0 19 17 1 0 20 19 2 0 13 8 2 0 20 18 1 0 M END > 48590 > J. Med. Chem. 41(25)-1998 5020-5036 > PPAR-gamma > 5.6000 $$$$ SciTegic07100714482D 21 22 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 0.0000 1.5000 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -0.0031 -3.0008 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 -1.3092 -5.2494 0.0000 C 0 0 2.6003 1.4978 0.0000 S 0 0 5.2003 1.4932 0.0000 C 0 0 -2.6108 -5.9949 0.0000 C 0 0 6.2387 0.8918 0.0000 O 0 0 3.8990 0.7455 0.0000 C 0 0 -2.3383 1.3500 0.0000 Cl 0 0 5.2024 2.6932 0.0000 O 0 0 -2.6004 -2.9949 0.0000 C 0 0 -3.9020 -3.7404 0.0000 C 0 0 -0.2720 -5.8530 0.0000 C 0 0 -3.9072 -5.2404 0.0000 C 0 0 -2.6149 -7.1949 0.0000 C 0 0 2 3 1 0 3 1 2 0 4 1 1 0 5 7 1 0 6 4 1 0 7 4 2 0 8 6 1 0 9 8 1 0 10 3 1 0 11 14 1 0 12 9 2 0 13 11 2 0 14 10 1 0 15 5 1 0 16 11 1 0 17 8 2 0 18 17 1 0 19 9 1 0 20 18 2 0 21 12 1 0 5 2 2 0 12 20 1 0 M END > 92461 > J. Med. Chem. 45(4)-2002 789-804 > PPAR-gamma > 4.5331 $$$$ SciTegic07100714482D 23 25 0 0 0 0 999 V2000 3.3372 -5.2929 0.0000 N 0 0 1.8372 -5.2877 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 1.3786 -3.8595 0.0000 S 0 0 2.5951 -3.0039 0.0000 C 0 0 1.1285 -6.2561 0.0000 O 0 0 4.9460 -3.4943 0.0000 O 0 0 2.5973 -1.5031 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -3.8913 4.9570 0.0000 C 0 0 -3.8600 2.2778 0.0000 C 0 0 -5.1548 4.5302 0.0000 C 0 0 -5.1605 1.5302 0.0000 C 0 0 -6.4553 3.7827 0.0000 C 0 0 -6.4581 2.2827 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 2 2 0 7 3 2 0 8 5 1 0 9 12 1 0 10 13 1 0 11 8 1 0 12 10 1 0 13 17 1 0 14 11 2 0 15 11 1 0 16 14 1 0 17 15 2 0 18 9 1 0 19 9 1 0 20 9 1 0 21 19 1 0 22 20 1 0 23 22 1 0 4 5 1 0 16 13 2 0 23 21 1 0 M END > 48610 > J. Med. Chem. 41(25)-1998 5020-5036 > PPAR-gamma > 4.6400 $$$$ SciTegic07100714482D 23 23 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 O 0 0 2.5951 -3.0039 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -2.5973 1.5031 0.0000 C 0 0 3.8916 -4.9570 0.0000 O 0 0 -3.6375 0.9049 0.0000 O 0 0 4.9336 -3.1588 0.0000 O 0 0 1.5568 -2.4023 0.0000 C 0 0 1.5548 -3.6021 0.0000 C 0 0 -0.0031 -3.0008 0.0000 C 0 0 2.5972 1.5031 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 -1.3039 -3.7494 0.0000 C 0 0 -3.6331 3.6060 0.0000 C 0 0 -1.3064 -4.9494 0.0000 C 0 0 3.6331 3.6061 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 8 2 0 5 1 1 0 6 1 2 0 7 3 1 0 8 6 1 0 9 5 2 0 10 4 1 0 11 7 2 0 12 10 2 0 13 7 1 0 14 3 1 0 15 3 1 0 16 6 1 0 17 5 1 0 18 10 1 0 19 17 1 0 20 16 1 0 21 18 1 0 22 20 1 0 23 19 1 0 4 9 1 0 M END > 150105 > J. Med. Chem. 48(7)-2005 2262-2265 > PPAR-gamma > 5.8861 $$$$ SciTegic07100714482D 24 25 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 -2.3155 0.7475 0.0000 C 0 0 1.7138 1.2033 0.0000 O 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6187 1.4919 0.0000 O 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -3.6267 2.9927 0.0000 C 0 0 -4.9300 3.7369 0.0000 C 0 0 -4.9364 4.9369 0.0000 O 0 0 2.1855 -2.6254 0.0000 O 0 0 -5.9662 3.1317 0.0000 O 0 0 -0.9971 3.0138 0.0000 C 0 0 -3.6187 -1.4919 0.0000 C 0 0 -2.5844 2.3981 0.0000 C 0 0 -2.7632 3.4971 0.0000 C 0 0 3.3606 -2.8684 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -3.6267 -2.9927 0.0000 C 0 0 -2.2889 4.9699 0.0000 C 0 0 -4.6688 -3.5878 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 7 2 0 5 10 1 0 6 2 1 0 7 1 1 0 8 5 1 0 9 1 1 0 10 9 2 0 11 8 1 0 12 11 1 0 13 12 2 0 14 7 1 0 15 12 1 0 16 3 1 0 17 10 1 0 18 11 1 0 19 11 1 0 20 14 1 0 21 16 1 0 22 17 1 0 23 21 1 0 24 22 1 0 4 6 1 0 5 3 2 0 M END > 150102 > J. Med. Chem. 48(7)-2005 2262-2265 > PPAR-gamma > 5.9586 $$$$ SciTegic07100714482D 25 26 0 0 0 0 999 V2000 9.0836 -9.7649 0.0000 C 0 0 10.3817 -10.5181 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 9.0857 -8.2641 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 10.3800 -11.7181 0.0000 O 0 0 3.6375 -0.9049 0.0000 O 0 0 2.5951 -3.0039 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 7.7875 -7.5110 0.0000 C 0 0 11.4220 -9.9199 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 5.1894 -6.0109 0.0000 C 0 0 -2.3383 1.3500 0.0000 Cl 0 0 7.7876 -6.0110 0.0000 C 0 0 6.4885 -8.2610 0.0000 C 0 0 6.4885 -5.2610 0.0000 C 0 0 5.1895 -7.5109 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 8.0453 -9.1633 0.0000 C 0 0 8.0433 -10.3631 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 2 1 1 0 3 8 1 0 4 1 1 0 5 3 1 0 6 2 2 0 7 3 2 0 8 22 1 0 9 5 2 0 10 5 1 0 11 4 1 0 12 2 1 0 13 15 1 0 14 9 1 0 15 10 2 0 16 21 2 0 17 13 1 0 18 11 1 0 19 11 2 0 20 18 2 0 21 19 1 0 22 25 1 0 23 1 1 0 24 1 1 0 25 16 1 0 20 16 1 0 14 13 2 0 M END > 92462 > J. Med. Chem. 45(4)-2002 789-804 > PPAR-gamma > 4.1337 $$$$ SciTegic07100714482D 25 26 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 -5.2003 -1.4932 0.0000 C 0 0 2.5951 -3.0039 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -3.8990 -0.7455 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.6003 -1.4978 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 -6.2387 -0.8918 0.0000 O 0 0 0.0000 1.5000 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -5.2024 -2.6932 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 2.5972 1.5031 0.0000 O 0 0 3.8912 -5.2578 0.0000 C 0 0 -3.8933 0.7553 0.0000 C 0 0 2.5955 2.7031 0.0000 C 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 -2.8522 1.3520 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 2 1 1 0 3 7 1 0 4 2 1 0 5 1 2 0 6 1 1 0 7 9 1 0 8 6 2 0 9 8 1 0 10 2 2 0 11 3 2 0 12 5 1 0 13 4 1 0 14 3 1 0 15 8 1 0 16 5 1 0 17 13 1 0 18 7 1 0 19 16 1 0 20 17 1 0 21 17 2 0 22 18 1 0 23 21 1 0 24 20 2 0 25 23 2 0 12 15 2 0 25 24 1 0 M END > 112934 > J. Med. Chem. 46(17)-2003 3581-3599 > PPAR-gamma > 5.0000 $$$$ SciTegic07100714482D 25 26 0 0 1 0 999 V2000 0.2131 -0.6366 0.0000 C 0 0 1 0 0 0 -0.2768 0.7653 0.0000 C 0 0 2 0 0 0 1.7283 -0.5930 0.0000 C 0 0 1 0 0 0 2.6484 -1.7751 0.0000 C 0 0 2.1368 0.8623 0.0000 C 0 0 1 0 0 0 -2.1968 -0.7054 0.0000 C 0 0 0.9109 1.7004 0.0000 C 0 0 -0.9464 -1.5755 0.0000 C 0 0 -1.7638 0.7179 0.0000 C 0 0 2.0847 -3.1660 0.0000 C 0 0 -7.0467 -5.0938 0.0000 C 0 0 -3.6157 -1.1864 0.0000 C 0 0 -7.2819 -6.2705 0.0000 O 0 0 3.2646 1.2724 0.0000 O 0 0 -7.9484 -4.3020 0.0000 O 0 0 3.0066 -4.3503 0.0000 C 0 0 1 0 0 0 4.1951 -4.1850 0.0000 O 0 0 -5.6254 -4.6118 0.0000 C 0 0 -3.9099 -2.6581 0.0000 C 0 0 2.4428 -5.7412 0.0000 C 0 0 -5.3312 -3.1401 0.0000 C 0 0 3.7228 -9.5007 0.0000 C 0 0 2.8009 -8.3164 0.0000 C 0 0 3.3647 -6.9255 0.0000 C 0 0 3.2721 -10.6128 0.0000 C 0 0 2 1 1 0 3 1 1 0 3 4 1 6 5 3 1 0 6 8 1 0 2 7 1 1 1 8 1 1 9 2 1 0 10 4 2 0 11 18 1 0 12 6 2 0 13 11 2 0 5 14 1 1 15 11 1 0 16 10 1 0 16 17 1 1 18 21 1 0 19 12 1 0 20 16 1 0 21 19 1 0 22 23 1 0 23 24 1 0 24 20 1 0 25 22 1 0 6 9 1 0 7 5 1 0 M END > 126418 > J. Med. Chem. 46(23)-2003 4883-4894 > PPAR-gamma > 5.1018 $$$$ SciTegic07100714482D 25 27 0 0 0 0 999 V2000 6.7820 12.3045 0.0000 N 0 0 7.5320 11.0054 0.0000 C 0 0 5.3148 11.9926 0.0000 C 0 0 6.5283 9.8907 0.0000 S 0 0 5.1769 10.5118 0.0000 C 0 0 1.2990 -0.7500 0.0000 N 0 0 8.7254 10.8800 0.0000 O 0 0 4.4182 12.7903 0.0000 O 0 0 3.8786 9.7588 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 3.8807 8.2579 0.0000 C 0 0 3.8912 5.2578 0.0000 C 0 0 2.5972 1.5031 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 2.5843 7.5034 0.0000 C 0 0 5.1824 7.5124 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 2.5895 6.0034 0.0000 C 0 0 5.1876 6.0124 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 3.8933 3.7570 0.0000 O 0 0 -2.5972 -1.5031 0.0000 C 0 0 -2.5955 -2.7031 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 10 1 0 7 2 2 0 8 3 2 0 9 5 1 0 10 14 1 0 11 6 2 0 12 9 1 0 13 21 1 0 14 19 1 0 15 22 2 0 16 10 2 0 17 12 2 0 18 12 1 0 19 23 1 0 20 17 1 0 21 18 2 0 22 16 1 0 23 13 1 0 24 15 1 0 25 24 1 0 4 5 1 0 13 20 2 0 15 11 1 0 M END > 126417 > J. Med. Chem. 46(23)-2003 4883-4894 > PPAR-gamma > 6.0132 $$$$ SciTegic07100714482D 25 27 0 0 0 0 999 V2000 9.8255 -12.0540 0.0000 N 0 0 8.3255 -12.0487 0.0000 C 0 0 10.2940 -10.6290 0.0000 C 0 0 7.8670 -10.6205 0.0000 S 0 0 9.0836 -9.7649 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 7.6168 -13.0171 0.0000 O 0 0 2.5973 -1.5031 0.0000 N 0 0 11.4344 -10.2554 0.0000 O 0 0 9.0857 -8.2641 0.0000 C 0 0 7.7875 -7.5110 0.0000 C 0 0 5.1894 -6.0109 0.0000 C 0 0 7.7876 -6.0110 0.0000 C 0 0 6.4885 -8.2610 0.0000 C 0 0 6.4885 -5.2610 0.0000 C 0 0 5.1895 -7.5109 0.0000 C 0 0 3.8912 -5.2578 0.0000 O 0 0 3.8933 -3.7570 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.6375 -0.9049 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 9 1 0 7 6 2 0 8 2 2 0 9 20 1 0 10 3 2 0 11 5 1 0 12 11 1 0 13 17 2 0 14 12 1 0 15 12 2 0 16 14 2 0 17 15 1 0 18 13 1 0 19 18 1 0 20 19 1 0 21 6 1 0 22 7 1 0 23 9 1 0 24 21 2 0 25 24 1 0 5 4 1 0 16 13 1 0 22 25 2 0 M END > 87155 > J. Med. Chem. 44(13)-2001 2061-2064 > PPAR-gamma > 6.1824 $$$$ SciTegic07100714482D 26 27 0 0 1 0 999 V2000 -5.1894 6.0109 0.0000 C 0 0 1.2956 -3.7547 0.0000 C 0 0 -6.4876 6.7640 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 2 0 0 0 -3.8912 5.2578 0.0000 C 0 0 1.2952 -4.9547 0.0000 O 0 0 2.5973 -1.5031 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -7.7858 7.5170 0.0000 C 0 0 0.2564 -3.1547 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 3.8933 -3.7570 0.0000 O 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 -2.5951 3.0039 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 -9.0864 6.7697 0.0000 C 0 0 -7.7828 9.0170 0.0000 C 0 0 4.9292 -5.8600 0.0000 C 0 0 -9.0802 9.7697 0.0000 C 0 0 -10.3839 7.5224 0.0000 C 0 0 -10.3808 9.0224 0.0000 C 0 0 2 4 1 0 3 1 3 0 4 7 1 0 5 1 1 0 6 2 2 0 7 9 1 0 8 5 2 0 9 15 1 0 10 3 1 0 11 2 1 0 12 18 1 0 4 13 1 6 14 16 1 0 15 17 2 0 16 12 2 0 17 12 1 0 18 19 1 0 19 8 1 0 20 13 1 0 21 10 2 0 22 10 1 0 23 20 1 0 24 22 2 0 25 21 1 0 26 24 1 0 25 26 2 0 14 9 2 0 M END > 126410 > J. Med. Chem. 46(23)-2003 4883-4894 > PPAR-gamma > 5.9469 $$$$ SciTegic07100714482D 27 29 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 O 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -9.0988 -6.0255 0.0000 C 0 0 -6.4988 -6.0116 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -7.8028 -5.2685 0.0000 C 0 0 -5.2025 -5.2568 0.0000 C 0 0 -10.1414 -5.4314 0.0000 O 0 0 -3.9091 -1.5019 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 -9.0923 -7.2255 0.0000 O 0 0 -5.2049 -3.7560 0.0000 O 0 0 -3.9067 -3.0027 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -6.4935 -7.5116 0.0000 C 0 0 -3.9008 -6.0022 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1917 -8.2569 0.0000 C 0 0 -2.5824 4.9544 0.0000 C 0 0 -3.8954 -7.5022 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 1 1 0 5 2 1 0 6 4 1 0 7 10 1 0 8 11 1 0 9 2 2 0 10 8 1 0 11 16 1 0 12 7 2 0 13 5 1 0 14 1 1 0 15 7 1 0 16 17 1 0 17 13 1 0 18 4 2 0 19 6 2 0 20 8 2 0 21 11 2 0 22 14 1 0 23 18 1 0 24 23 2 0 25 27 2 0 26 22 1 0 27 21 1 0 5 3 1 0 19 24 1 0 20 25 1 0 M END > 116550 > J. Med. Chem. 47(1)-2004 196-209 > PPAR-gamma > 5.3010 $$$$ SciTegic07100714482D 27 29 0 0 0 0 999 V2000 -2.6747 6.1134 0.0000 N 0 0 -3.1333 7.5416 0.0000 C 0 0 -4.6333 7.5468 0.0000 O 0 0 -3.8912 5.2578 0.0000 C 0 0 -5.1017 6.1218 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 2.5973 -1.5031 0.0000 O 0 0 -2.2469 8.7527 0.0000 C 0 0 3.8916 -4.9570 0.0000 O 0 0 -3.8933 3.7570 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 4.9336 -3.1588 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 -6.2421 5.7482 0.0000 C 0 0 1.5548 -3.6021 0.0000 C 0 0 -0.7527 8.7026 0.0000 C 0 0 -2.9588 10.0749 0.0000 C 0 0 0.0396 9.9763 0.0000 C 0 0 -2.1665 11.3486 0.0000 C 0 0 -0.6674 11.2993 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 1 1 0 5 4 2 0 6 7 1 0 7 8 1 0 8 12 1 0 9 2 1 0 10 6 2 0 11 4 1 0 12 17 2 0 13 6 1 0 14 20 1 0 15 11 1 0 16 18 2 0 17 19 1 0 18 14 1 0 19 14 2 0 20 15 1 0 21 5 1 0 22 7 1 0 23 9 1 0 24 9 2 0 25 23 2 0 26 24 1 0 27 26 2 0 5 3 1 0 27 25 1 0 16 12 1 0 M END > 87151 > J. Med. Chem. 44(13)-2001 2061-2064 > PPAR-gamma > 5.5605 $$$$ SciTegic07100714482D 28 30 0 0 1 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 C 0 0 1.7138 1.2033 0.0000 O 0 0 2.5889 0.0182 0.0000 N 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -3.2855 1.8927 0.0000 O 0 0 -2.3155 -0.7475 0.0000 C 0 0 -4.7625 1.6263 0.0000 C 0 0 2 0 0 0 -5.2669 0.2128 0.0000 C 0 0 2.0907 -2.3426 0.0000 O 0 0 -4.4904 -0.7021 0.0000 O 0 0 -5.7324 2.7716 0.0000 C 0 0 -6.4474 -0.0026 0.0000 O 0 0 3.7889 0.0269 0.0000 C 0 0 -0.9971 3.0138 0.0000 C 0 0 -3.6187 -1.4919 0.0000 C 0 0 -7.2090 2.5075 0.0000 C 0 0 -5.2229 4.1825 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -3.6267 -2.9927 0.0000 C 0 0 -2.2889 4.9699 0.0000 C 0 0 -4.6688 -3.5878 0.0000 C 0 0 -6.1900 5.3292 0.0000 C 0 0 -8.1761 3.6542 0.0000 C 0 0 -7.6666 5.0650 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 3 1 0 6 2 1 0 7 10 1 0 8 1 1 0 9 7 1 0 10 8 2 0 11 9 1 6 12 11 1 0 13 3 2 0 14 12 2 0 15 11 1 0 16 12 1 0 17 5 1 0 18 6 1 0 19 10 1 0 20 15 1 0 21 15 2 0 22 18 1 0 23 19 1 0 24 22 1 0 25 23 1 0 26 21 1 0 27 20 2 0 28 26 2 0 4 5 1 0 7 6 2 0 28 27 1 0 M END > 153123 > J. Med. Chem. 48(13)-2005 4457-4468 > PPAR-gamma > 6.4089 $$$$ SciTegic07100714482D 28 31 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 15.5587 5.6927 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 14.2486 6.4232 0.0000 C 0 0 15.2688 4.2210 0.0000 C 0 0 1.7138 1.2033 0.0000 O 0 0 13.1490 5.4030 0.0000 S 0 0 13.7901 4.0610 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 4.0872 0.0382 0.0000 N 0 0 14.1054 7.6147 0.0000 O 0 0 16.0797 3.3364 0.0000 O 0 0 13.0565 2.7517 0.0000 C 0 0 11.5558 2.7315 0.0000 C 0 0 8.5559 2.6972 0.0000 C 0 0 10.7910 4.0219 0.0000 C 0 0 10.8207 1.4240 0.0000 C 0 0 9.2911 4.0047 0.0000 C 0 0 9.3208 1.4068 0.0000 C 0 0 7.0552 2.6770 0.0000 O 0 0 6.3215 1.3677 0.0000 C 0 0 4.8208 1.3475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 4.7008 -0.9930 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 5 1 0 3 1 2 0 4 7 1 0 5 8 1 0 6 1 1 0 7 8 1 0 8 14 1 0 9 3 1 0 10 6 1 0 11 1 1 0 12 4 2 0 13 5 2 0 14 15 1 0 15 18 2 0 16 21 1 0 17 19 2 0 18 20 1 0 19 16 1 0 20 16 2 0 21 22 1 0 22 23 1 0 23 11 1 0 24 9 2 0 25 10 2 0 26 11 1 0 27 25 1 0 28 24 1 0 9 10 1 0 28 27 2 0 17 15 1 0 2 4 1 0 M END > 48614 > J. Med. Chem. 41(25)-1998 5020-5036 > PPAR-gamma > 7.9500 $$$$ SciTegic07100714482D 29 32 0 0 0 0 999 V2000 3.3372 -5.2929 0.0000 N 0 0 -2.6747 6.1134 0.0000 N 0 0 -3.1333 7.5416 0.0000 C 0 0 1.8372 -5.2877 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 -4.6332 7.5468 0.0000 O 0 0 -3.8912 5.2578 0.0000 C 0 0 1.3786 -3.8595 0.0000 S 0 0 -5.1017 6.1218 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 1.1285 -6.2561 0.0000 O 0 0 -2.2469 8.7527 0.0000 C 0 0 4.9460 -3.4943 0.0000 O 0 0 2.5973 -1.5031 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 -6.2421 5.7482 0.0000 C 0 0 -2.7465 10.1618 0.0000 C 0 0 -0.7713 8.4740 0.0000 C 0 0 -1.7720 11.3021 0.0000 C 0 0 0.2032 9.6143 0.0000 C 0 0 -0.2972 11.0284 0.0000 C 0 0 2 7 1 0 3 2 2 0 4 1 1 0 5 1 1 0 6 9 1 0 7 15 1 0 8 4 1 0 9 7 2 0 10 5 1 0 11 4 2 0 12 3 1 0 13 5 2 0 14 10 1 0 15 18 1 0 16 14 1 0 17 22 1 0 18 23 1 0 19 16 2 0 20 16 1 0 21 19 1 0 22 20 2 0 23 17 1 0 24 9 1 0 25 12 1 0 26 12 2 0 27 25 2 0 28 26 1 0 29 28 2 0 10 8 1 0 17 21 2 0 6 3 1 0 29 27 1 0 M END > 87159 > J. Med. Chem. 44(13)-2001 2061-2064 > PPAR-gamma > 8.0969 $$$$ SciTegic07100714482D 30 32 0 0 0 0 999 V2000 -2.9153 5.5365 0.0000 N 0 0 -3.6607 4.2349 0.0000 C 0 0 -1.4470 5.2297 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -2.6532 3.1236 0.0000 S 0 0 10.3891 1.5230 0.0000 C 0 0 -1.3039 3.7494 0.0000 C 0 0 2.6003 -1.4977 0.0000 C 0 0 3.8990 -0.7455 0.0000 N 0 0 9.0919 0.7681 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -4.8537 4.1053 0.0000 O 0 0 -0.0031 3.0008 0.0000 C 0 0 -0.5532 6.0305 0.0000 O 0 0 0.0000 1.5000 0.0000 C 0 0 2.6024 -2.6977 0.0000 O 0 0 10.3857 2.7230 0.0000 F 0 0 11.4302 0.9263 0.0000 F 0 0 11.4265 2.1261 0.0000 F 0 0 -1.2990 -0.7500 0.0000 C 0 0 9.0971 -0.7319 0.0000 C 0 0 7.7903 1.5136 0.0000 C 0 0 5.2003 -1.4932 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 6.4990 -0.7409 0.0000 C 0 0 7.8007 -1.4864 0.0000 C 0 0 6.4939 0.7591 0.0000 C 0 0 -0.0031 -3.0008 0.0000 O 0 0 -1.0432 -3.5994 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 12 2 0 5 2 1 0 6 10 1 0 7 3 1 0 8 4 1 0 9 8 1 0 10 23 1 0 11 21 2 0 12 16 1 0 13 2 2 0 14 7 1 0 15 3 2 0 16 14 1 0 17 8 2 0 18 6 1 0 19 6 1 0 20 6 1 0 21 25 1 0 22 27 1 0 23 28 2 0 24 9 1 0 25 16 2 0 26 24 1 0 27 26 2 0 28 26 1 0 29 11 1 0 30 29 1 0 7 5 1 0 4 11 1 0 22 10 2 0 M END > 87158 > J. Med. Chem. 44(13)-2001 2061-2064 > PPAR-gamma > 5.9626 $$$$ SciTegic07100714482D 30 33 0 0 0 0 999 V2000 0.0000 -1.3190 0.0000 N 0 0 -1.2274 -0.6045 0.0000 C 0 0 1.2274 -0.6045 0.0000 C 0 0 1.2274 0.8244 0.0000 C 0 0 -1.2274 0.8244 0.0000 C 0 0 5.2181 -10.3143 0.0000 C 0 0 6.5150 -9.5589 0.0000 C 0 0 5.2219 -11.5143 0.0000 O 0 0 -3.7006 -0.6045 0.0000 N 0 0 6.5120 -8.0581 0.0000 C 0 0 0.0031 -2.8205 0.0000 C 0 0 -2.4915 -1.3190 0.0000 C 0 0 5.2112 -7.3095 0.0000 C 0 0 4.1768 -9.7179 0.0000 O 0 0 2.6078 -5.8185 0.0000 C 0 0 -2.4915 1.5389 0.0000 C 0 0 2.4732 -1.3190 0.0000 C 0 0 7.8158 -10.3075 0.0000 O 0 0 3.9147 -8.0640 0.0000 C 0 0 5.2060 -5.8095 0.0000 C 0 0 2.4732 1.5389 0.0000 C 0 0 2.6131 -7.3185 0.0000 C 0 0 3.9043 -5.0640 0.0000 C 0 0 1.3070 -5.0699 0.0000 O 0 0 1.3039 -3.5691 0.0000 C 0 0 -3.7006 0.8244 0.0000 C 0 0 7.8189 -11.8084 0.0000 C 0 0 3.7372 0.8244 0.0000 C 0 0 3.7372 -0.6045 0.0000 C 0 0 8.8589 -12.4069 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 2 0 6 7 1 0 7 10 1 0 8 6 2 0 9 12 2 0 10 13 1 0 11 1 1 0 12 2 1 0 13 20 2 0 14 6 1 0 15 24 1 0 16 5 1 0 17 3 1 0 18 7 1 0 19 22 2 0 20 23 1 0 21 4 1 0 22 15 1 0 23 15 2 0 24 25 1 0 25 11 1 0 26 9 1 0 27 18 1 0 28 29 1 0 29 17 2 0 30 27 1 0 4 5 1 0 21 28 2 0 16 26 2 0 19 13 1 0 M END > 92455 > J. Med. Chem. 45(4)-2002 789-804 > PPAR-gamma > 7.0410 $$$$ SciTegic07100714482D 31 33 0 0 1 0 999 V2000 5.1894 -6.0109 0.0000 C 0 0 6.4912 -5.2640 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 2 0 0 0 1.2925 -3.7494 0.0000 C 0 0 3.8933 -3.7570 0.0000 N 0 0 2.5973 -1.5031 0.0000 C 0 0 0.2552 -3.1461 0.0000 O 0 0 6.4940 -4.0640 0.0000 O 0 0 7.7894 -6.0171 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 1.2883 -4.9494 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -3.8933 3.7570 0.0000 C 0 0 2.8509 -5.8560 0.0000 C 0 0 9.0915 -5.2725 0.0000 C 0 0 7.7833 -7.5171 0.0000 C 0 0 -3.8934 5.2570 0.0000 C 0 0 -5.1925 3.0070 0.0000 C 0 0 9.0793 -8.2724 0.0000 C 0 0 10.3875 -6.0278 0.0000 C 0 0 -5.1924 6.0070 0.0000 C 0 0 -6.4915 3.7571 0.0000 C 0 0 -6.4915 5.2571 0.0000 C 0 0 10.3814 -7.5278 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 6 1 1 5 4 1 0 6 3 1 0 7 4 1 0 8 5 2 0 9 2 2 0 10 2 1 0 11 14 1 0 12 7 1 0 13 5 1 0 14 19 2 0 15 11 1 0 16 12 1 0 17 12 2 0 18 16 2 0 19 17 1 0 20 15 1 0 21 3 1 0 22 10 2 0 23 10 1 0 24 20 1 0 25 20 2 0 26 23 2 0 27 22 1 0 28 24 2 0 29 25 1 0 30 29 2 0 31 26 1 0 31 27 2 0 14 18 1 0 28 30 1 0 M END > 48616 > J. Med. Chem. 41(25)-1998 5020-5036 > PPAR-gamma > 4.6600 $$$$ SciTegic07100714482D 31 34 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 O 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 -9.0988 -6.0255 0.0000 C 0 0 -6.4988 -6.0116 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -7.8028 -5.2685 0.0000 C 0 0 -5.2025 -5.2568 0.0000 C 0 0 -10.1414 -5.4314 0.0000 O 0 0 -3.9091 -1.5019 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -9.0923 -7.2255 0.0000 O 0 0 -5.2049 -3.7560 0.0000 O 0 0 -3.9067 -3.0027 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -6.4935 -7.5116 0.0000 C 0 0 -3.9008 -6.0022 0.0000 C 0 0 -3.7896 6.1222 0.0000 C 0 0 -1.3626 6.1078 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1917 -8.2569 0.0000 C 0 0 -3.8954 -7.5022 0.0000 C 0 0 -1.8176 7.5371 0.0000 C 0 0 -3.3176 7.5460 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 1 1 0 5 2 1 0 6 4 1 0 7 1 1 0 8 11 1 0 9 12 1 0 10 2 2 0 11 9 1 0 12 17 1 0 13 8 2 0 14 5 1 0 15 7 1 0 16 8 1 0 17 18 1 0 18 14 1 0 19 4 2 0 20 6 2 0 21 15 1 0 22 9 2 0 23 12 2 0 24 21 1 0 25 21 1 0 26 19 1 0 27 26 2 0 28 29 2 0 29 23 1 0 30 25 1 0 31 24 1 0 5 3 1 0 20 27 1 0 31 30 1 0 22 28 1 0 M END > 116563 > J. Med. Chem. 47(1)-2004 196-209 > PPAR-gamma > 5.3010 $$$$ SciTegic07100714482D 31 33 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 -5.2003 -1.4932 0.0000 C 0 0 2.5951 -3.0039 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -3.8990 -0.7455 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.6003 -1.4978 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 -6.2387 -0.8918 0.0000 O 0 0 0.0000 1.5000 0.0000 C 0 0 3.8756 -9.7586 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -5.2024 -2.6932 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 2.5972 1.5031 0.0000 O 0 0 -3.8933 0.7553 0.0000 C 0 0 2.5752 -10.5063 0.0000 C 0 0 5.1733 -10.5112 0.0000 C 0 0 2.5955 2.7031 0.0000 C 0 0 -2.8522 1.3520 0.0000 C 0 0 5.1705 -12.0112 0.0000 C 0 0 2.5724 -12.0063 0.0000 C 0 0 3.8700 -12.7587 0.0000 C 0 0 2 1 1 0 3 7 1 0 4 2 1 0 5 1 2 0 6 1 1 0 7 10 1 0 8 16 2 0 9 6 2 0 10 9 1 0 11 2 2 0 12 3 2 0 13 5 1 0 14 8 1 0 15 21 2 0 16 22 1 0 17 4 1 0 18 3 1 0 19 9 1 0 20 17 1 0 21 20 1 0 22 20 2 0 23 5 1 0 24 7 1 0 25 14 2 0 26 14 1 0 27 23 1 0 28 24 1 0 29 26 2 0 30 25 1 0 31 29 1 0 13 19 2 0 8 15 1 0 30 31 2 0 M END > 112944 > J. Med. Chem. 46(17)-2003 3581-3599 > PPAR-gamma > 5.3979 $$$$ SciTegic07100714482D 32 34 0 0 0 0 999 V2000 -4.0312 5.2378 0.0000 N 0 0 -5.4984 5.5497 0.0000 C 0 0 -6.2484 4.2507 0.0000 N 0 0 -5.2447 3.1359 0.0000 N 0 0 -3.8933 3.7570 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -7.7382 4.0909 0.0000 C 0 0 -5.9865 6.6459 0.0000 O 0 0 2.5973 -1.5031 0.0000 O 0 0 -2.5951 3.0039 0.0000 C 0 0 3.8916 -4.9570 0.0000 O 0 0 -2.9081 6.2294 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -8.3466 2.7190 0.0000 C 0 0 4.9336 -3.1588 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5973 1.5031 0.0000 C 0 0 -9.5573 -0.0260 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -9.8379 2.5569 0.0000 C 0 0 -7.4607 1.5085 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -8.0661 0.1360 0.0000 C 0 0 -10.4432 1.1845 0.0000 C 0 0 1.5568 -2.4023 0.0000 C 0 0 1.5548 -3.6021 0.0000 C 0 0 -10.0416 -1.1239 0.0000 C 0 0 -1.4851 5.7526 0.0000 C 0 0 -0.5855 6.5467 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 5 2 0 5 1 1 0 6 10 1 0 7 6 1 0 8 3 1 0 9 2 2 0 10 14 1 0 11 5 1 0 12 7 2 0 13 1 1 0 14 21 1 0 15 8 1 0 16 7 1 0 17 18 1 0 18 11 1 0 19 26 2 0 20 24 1 0 21 25 2 0 22 15 1 0 23 15 2 0 24 17 2 0 25 17 1 0 26 23 1 0 27 22 2 0 28 6 1 0 29 6 1 0 30 19 1 0 31 13 1 0 32 31 1 0 4 3 1 0 20 14 2 0 27 19 1 0 M END > 115008 > J. Med. Chem. 46(24)-2003 5121-5124 > PPAR-gamma > 5.5376 $$$$ SciTegic07100714482D 32 35 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 O 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -9.0988 -6.0255 0.0000 C 0 0 -6.4988 -6.0116 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -7.8028 -5.2685 0.0000 C 0 0 -5.2025 -5.2568 0.0000 C 0 0 -10.1414 -5.4314 0.0000 O 0 0 -1.2907 2.9981 0.0000 C 0 0 -3.9091 -1.5019 0.0000 C 0 0 -9.0923 -7.2255 0.0000 O 0 0 -5.2049 -3.7560 0.0000 O 0 0 -3.9067 -3.0027 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -6.4935 -7.5116 0.0000 C 0 0 -3.8775 6.0115 0.0000 C 0 0 -3.9008 -6.0022 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -4.0118 7.4927 0.0000 C 0 0 -5.2305 5.3938 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1917 -8.2569 0.0000 C 0 0 -3.8954 -7.5022 0.0000 C 0 0 -5.4782 7.8082 0.0000 C 0 0 -6.2314 6.5110 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 1 1 0 5 2 1 0 6 4 1 0 7 10 1 0 8 11 1 0 9 2 2 0 10 8 1 0 11 16 1 0 12 7 2 0 13 1 1 0 14 5 1 0 15 7 1 0 16 17 1 0 17 14 1 0 18 4 2 0 19 6 2 0 20 13 1 0 21 8 2 0 22 24 1 0 23 11 2 0 24 20 1 0 25 22 1 0 26 22 1 0 27 18 1 0 28 27 2 0 29 30 2 0 30 23 1 0 31 25 1 0 32 26 1 0 5 3 1 0 19 28 1 0 31 32 1 0 21 29 1 0 M END > 116564 > J. Med. Chem. 47(1)-2004 196-209 > PPAR-gamma > 5.5686 $$$$ SciTegic07100714482D 32 34 0 0 0 0 999 V2000 -2.9153 5.5365 0.0000 N 0 0 -1.4470 5.2297 0.0000 C 0 0 -1.3039 3.7494 0.0000 N 0 0 -2.6532 3.1236 0.0000 N 0 0 -3.6607 4.2349 0.0000 C 0 0 -11.1455 -3.1317 0.0000 C 0 0 -11.7492 -4.5057 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -0.5532 6.0305 0.0000 O 0 0 -9.6538 -2.9665 0.0000 O 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -12.9420 -4.6377 0.0000 O 0 0 -3.4072 6.6310 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -9.0501 -1.5925 0.0000 C 0 0 -5.1499 4.0700 0.0000 C 0 0 -11.0389 -5.4728 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -7.8490 1.1567 0.0000 C 0 0 -9.9402 -0.3851 0.0000 C 0 0 -7.5594 -1.4253 0.0000 C 0 0 -9.3396 0.9894 0.0000 C 0 0 -6.9589 -0.0508 0.0000 C 0 0 -10.6633 -2.0328 0.0000 C 0 0 -11.8559 -2.1645 0.0000 C 0 0 -5.7536 2.6959 0.0000 C 0 0 2.3383 -1.3500 0.0000 C 0 0 0.0000 -2.7000 0.0000 C 0 0 -7.2453 2.5307 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 5 2 0 5 1 1 0 6 10 1 0 7 6 1 0 8 3 1 0 9 2 2 0 10 18 1 0 11 13 1 0 12 8 1 0 13 12 2 0 14 17 1 0 15 7 2 0 16 1 1 0 17 21 2 0 18 24 1 0 19 5 1 0 20 7 1 0 21 12 1 0 22 32 1 0 23 25 1 0 24 26 2 0 25 22 2 0 26 22 1 0 27 6 1 0 28 6 1 0 29 19 1 0 30 11 1 0 31 14 1 0 32 29 1 0 4 3 1 0 23 18 2 0 11 14 2 0 M END > 115014 > J. Med. Chem. 46(24)-2003 5121-5124 > PPAR-gamma > 5.6383 $$$$ SciTegic07100714482D 32 35 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 O 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 -9.0988 -6.0255 0.0000 C 0 0 -6.4988 -6.0116 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -7.8028 -5.2685 0.0000 C 0 0 -5.2025 -5.2568 0.0000 C 0 0 -10.1414 -5.4314 0.0000 O 0 0 -3.9091 -1.5019 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -9.0923 -7.2255 0.0000 O 0 0 -5.2049 -3.7560 0.0000 O 0 0 -5.1815 5.2608 0.0000 C 0 0 -3.9067 -3.0027 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -6.4935 -7.5116 0.0000 C 0 0 -3.9008 -6.0022 0.0000 C 0 0 -6.2193 5.8633 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1917 -8.2569 0.0000 C 0 0 -3.8954 -7.5022 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 6 1 0 5 2 1 0 6 3 1 0 7 1 1 0 8 11 1 0 9 12 2 0 10 2 2 0 11 9 1 0 12 17 1 0 13 8 2 0 14 5 1 0 15 7 1 0 16 8 1 0 17 19 1 0 18 22 2 0 19 14 1 0 20 15 1 0 21 15 2 0 22 21 1 0 23 20 2 0 24 3 2 0 25 6 2 0 26 9 1 0 27 12 1 0 28 18 1 0 29 24 1 0 30 29 2 0 31 32 1 0 32 27 2 0 5 4 1 0 23 18 1 0 25 30 1 0 26 31 2 0 M END > 118004 > Bioorg. Med. Chem. Lett. 13(14)-2003 2359-2362 > PPAR-gamma > 5.6990 $$$$ SciTegic07100714482D 32 35 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 O 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 -9.0988 -6.0255 0.0000 C 0 0 -6.4988 -6.0116 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -7.8028 -5.2685 0.0000 C 0 0 -5.2025 -5.2568 0.0000 C 0 0 -10.1414 -5.4314 0.0000 O 0 0 -3.9091 -1.5019 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -9.0923 -7.2255 0.0000 O 0 0 -5.2049 -3.7560 0.0000 O 0 0 -3.9067 -3.0027 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -6.4935 -7.5116 0.0000 C 0 0 -3.9008 -6.0022 0.0000 C 0 0 -3.8758 6.0130 0.0000 C 0 0 -1.2777 5.9976 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1917 -8.2569 0.0000 C 0 0 -3.8954 -7.5022 0.0000 C 0 0 -1.2688 7.4976 0.0000 C 0 0 -3.8669 7.5130 0.0000 C 0 0 -2.5634 8.2553 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 1 1 0 5 2 1 0 6 4 1 0 7 1 1 0 8 11 1 0 9 12 1 0 10 2 2 0 11 9 1 0 12 17 1 0 13 8 2 0 14 5 1 0 15 7 1 0 16 8 1 0 17 18 1 0 18 14 1 0 19 4 2 0 20 6 2 0 21 15 1 0 22 9 2 0 23 12 2 0 24 21 1 0 25 21 1 0 26 19 1 0 27 26 2 0 28 29 2 0 29 23 1 0 30 25 1 0 31 24 1 0 32 30 1 0 5 3 1 0 20 27 1 0 31 32 1 0 22 28 1 0 M END > 116565 > J. Med. Chem. 47(1)-2004 196-209 > PPAR-gamma > 6.5229 $$$$ SciTegic07100714482D 33 36 0 0 0 0 999 V2000 -2.6747 6.1134 0.0000 N 0 0 -3.1333 7.5416 0.0000 C 0 0 -4.6333 7.5468 0.0000 O 0 0 -3.8912 5.2578 0.0000 C 0 0 -5.1017 6.1218 0.0000 C 0 0 1.2956 -3.7547 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 3.8933 -3.7570 0.0000 O 0 0 -2.2469 8.7527 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2952 -4.9547 0.0000 O 0 0 -3.8933 3.7570 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 0.2564 -3.1547 0.0000 O 0 0 3.8912 -5.2578 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -2.5973 1.5031 0.0000 O 0 0 -6.2421 5.7482 0.0000 C 0 0 -0.7527 8.7026 0.0000 C 0 0 -2.9588 10.0749 0.0000 C 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 -2.1665 11.3486 0.0000 C 0 0 0.0396 9.9763 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 -0.6674 11.2993 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 1 1 0 5 4 2 0 6 7 1 0 7 10 1 0 8 7 1 0 9 2 1 0 10 13 1 0 11 6 2 0 12 4 1 0 13 19 2 0 14 6 1 0 15 8 1 0 16 22 1 0 17 12 1 0 18 20 2 0 19 21 1 0 20 16 1 0 21 16 2 0 22 17 1 0 23 5 1 0 24 9 2 0 25 9 1 0 26 15 2 0 27 15 1 0 28 25 2 0 29 24 1 0 30 27 2 0 31 26 1 0 32 28 1 0 33 30 1 0 5 3 1 0 29 32 2 0 13 18 1 0 31 33 2 0 M END > 129141 > J. Med. Chem. 47(10)-2004 2422-2425 > PPAR-gamma > 6.4089 $$$$