SciTegic07090714142D 11 11 0 0 0 0 999 V2000 -1.3040 3.5228 0.0000 C 0 0 0.7500 -1.0323 0.0000 N 0 0 1.2135 0.3943 0.0000 N 0 0 0.0000 1.2760 0.0000 C 0 0 -1.3096 6.2236 0.0000 N 0 0 -3.6406 2.1682 0.0000 N 0 0 -1.3071 5.0236 0.0000 C 0 0 -2.6024 2.7701 0.0000 C 0 0 -0.0031 2.7742 0.0000 C 0 0 -1.2135 0.3943 0.0000 C 0 0 -0.7500 -1.0323 0.0000 C 0 0 2 3 1 0 3 4 1 0 4 9 1 0 5 7 3 0 6 8 3 0 7 1 1 0 8 1 1 0 9 1 2 0 10 4 2 0 11 10 1 0 11 2 2 0 M END > 65696 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 2.8297 $$$$ SciTegic07090714142D 14 15 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 3.7889 0.0269 0.0000 S 0 0 2.1812 2.6271 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 4.0244 4.0756 0.0000 O 0 0 4.4505 2.0415 0.0000 O 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 1 2 0 7 3 1 0 8 7 1 0 9 8 2 0 10 8 1 0 11 5 2 0 12 4 2 0 13 11 1 0 14 12 1 0 4 5 1 0 14 13 2 0 M END > 71050 > J. Med. Chem. 36(17)-1993 2459-2469 > EGFR > 4.8268 $$$$ SciTegic07090714142D 16 17 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 0.0122 3.7431 0.0000 C 0 0 -3.6235 4.3591 0.0000 N 0 0 1.0540 4.3387 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -2.6973 0.0000 O 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 3 1 0 6 3 1 0 7 5 3 0 8 6 3 0 9 4 2 0 10 1 1 0 11 2 2 0 12 9 1 0 13 14 1 0 14 10 1 0 15 11 1 0 16 15 2 0 13 4 1 0 16 9 1 0 M END > 65708 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 2.9208 $$$$ SciTegic07090714142D 17 18 0 0 0 0 999 V2000 -2.5951 3.0039 0.0000 C 0 0 -2.5973 1.5031 0.0000 C 0 0 -3.8056 3.8679 0.0000 C 0 0 -1.3786 3.8595 0.0000 C 0 0 -1.8372 5.2877 0.0000 C 0 0 -3.3372 5.2929 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -0.2409 3.4780 0.0000 O 0 0 -4.9460 3.4943 0.0000 O 0 0 2.3383 -1.3500 0.0000 O 0 0 2.3383 1.3500 0.0000 C 0 0 0.0000 -2.7000 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 1 1 0 5 4 1 0 6 3 1 0 7 9 1 0 8 2 1 0 9 12 2 0 10 11 1 0 11 8 2 0 12 8 1 0 13 4 2 0 14 3 2 0 15 7 1 0 16 9 1 0 17 10 1 0 5 6 2 0 10 7 2 0 M END > 78618 > Bioorg. Med. Chem. 10(10)-2002 3257-3265 > EGFR > 3.3565 $$$$ SciTegic07090714142D 17 19 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 S 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 4.0896 0.0290 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 4.9234 1.2700 0.0000 C 0 0 4.7453 -1.3220 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 7.0791 -0.1803 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.2418 -1.4248 0.0000 C 0 0 6.4199 1.1671 0.0000 C 0 0 -3.3560 1.3452 0.0000 O 0 0 8.2762 -0.2625 0.0000 O 0 0 2 1 2 0 3 1 1 0 4 3 1 0 5 2 1 0 6 4 2 0 7 1 1 0 8 5 2 0 9 7 2 0 10 7 1 0 11 6 1 0 12 14 1 0 13 8 1 0 14 10 2 0 15 9 1 0 16 11 1 0 17 12 1 0 5 4 1 0 15 12 2 0 13 11 2 0 M END > 140777 > J. Med. Chem. 37(11)-1994 1689-1695 > EGFR > 4.8861 $$$$ SciTegic07090714142D 17 19 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 6 2 0 6 3 1 0 7 2 1 0 8 4 1 0 9 2 2 0 10 7 2 0 11 8 2 0 12 8 1 0 13 9 1 0 14 13 2 0 15 12 2 0 16 11 1 0 17 15 1 0 5 7 1 0 14 10 1 0 17 16 2 0 M END > 36847 > J. Med. Chem. 40(10)-1997 1519-1529 > EGFR > 6.4609 $$$$ SciTegic07090714142D 18 20 0 0 0 0 999 V2000 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 4.2449 4.2986 0.0000 S 0 0 5.7359 4.1352 0.0000 C 0 0 4.7388 1.9224 0.0000 C 0 0 6.0412 2.6666 0.0000 C 0 0 3.7889 0.0269 0.0000 O 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 6.7457 5.2420 0.0000 C 0 0 7.9180 4.9856 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 1 0 5 1 2 0 6 4 1 0 7 5 1 0 8 7 1 0 9 8 1 0 10 7 2 0 11 10 1 0 12 2 2 0 13 4 2 0 14 6 2 0 15 9 1 0 16 15 1 0 17 13 1 0 18 17 2 0 6 3 1 0 9 11 2 0 18 14 1 0 M END > 44761 > J. Med. Chem. 41(14)-1998 2588-2603 > EGFR > 4.3565 $$$$ SciTegic07090714142D 18 20 0 0 0 0 999 V2000 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 2.1812 2.6271 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 4.1200 4.3600 0.0000 C 0 0 -0.9991 2.7132 0.0000 N 0 0 5.5886 4.6654 0.0000 C 0 0 5.9645 5.8050 0.0000 Cl 0 0 6.1174 2.1217 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 6.5873 3.5462 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 3 1 0 6 3 2 0 7 1 1 0 8 5 2 0 9 6 1 0 10 9 2 0 11 7 1 0 12 11 2 0 13 6 1 0 14 12 1 0 15 14 1 0 16 17 2 0 17 11 1 0 18 16 1 0 5 4 1 0 10 8 1 0 18 14 2 0 M END > 39524 > J. Med. Chem. 40(22)-1997 3601-3616 > EGFR > 4.4559 $$$$ SciTegic07090714142D 18 20 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 -0.9971 3.0138 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 3.7889 0.0269 0.0000 C 0 0 -2.2901 5.2700 0.0000 C 0 0 -3.5944 3.0231 0.0000 C 0 0 -4.8917 3.7761 0.0000 C 0 0 -3.5873 6.0231 0.0000 C 0 0 -4.8881 5.2761 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 5 2 0 7 2 2 0 8 3 1 0 9 3 1 0 10 8 2 0 11 9 1 0 12 5 1 0 13 6 1 0 14 11 1 0 15 11 1 0 16 15 1 0 17 14 1 0 18 16 1 0 6 4 1 0 7 10 1 0 17 18 1 0 M END > 31242 > J. Med. Chem. 39(12)-1996 2285-2292 > EGFR > 5.1599 $$$$ SciTegic07090714142D 18 20 0 0 0 0 999 V2000 1.2964 1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 6.4931 -2.9949 0.0000 N 0 0 3.8926 -1.4990 0.0000 C 0 0 -3.6486 1.3517 0.0000 O 0 0 -3.6486 -1.3517 0.0000 O 0 0 5.1953 -3.7469 0.0000 C 0 0 6.4907 -1.4949 0.0000 C 0 0 3.8951 -2.9990 0.0000 C 0 0 5.1905 -0.7469 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 2 1 0 5 4 2 0 6 5 1 0 7 10 1 0 8 3 1 0 9 7 2 0 10 1 2 0 11 16 1 0 12 7 1 0 13 5 1 0 14 6 1 0 15 17 1 0 16 18 2 0 17 12 2 0 18 12 1 0 3 9 1 0 8 6 2 0 15 11 2 0 M END > 18442 > J. Med. Chem. 37(17)-1994 2627-2629 > EGFR > 5.3010 $$$$ SciTegic07090714142D 18 20 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -3.8758 6.0130 0.0000 C 0 0 -1.2777 5.9976 0.0000 C 0 0 -1.2688 7.4976 0.0000 C 0 0 -3.8669 7.5130 0.0000 C 0 0 -2.5634 8.2553 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 6 2 0 6 3 1 0 7 2 1 0 8 13 2 0 9 4 1 0 10 2 2 0 11 9 1 0 12 7 2 0 13 10 1 0 14 11 2 0 15 11 1 0 16 15 2 0 17 14 1 0 18 16 1 0 7 5 1 0 8 12 1 0 17 18 2 0 M END > 30532 > J. Med. Chem. 39(9)-1996 1823-1835 > EGFR > 5.6925 $$$$ SciTegic07090714142D 18 19 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 2.5973 -1.5031 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 3.8934 -5.2570 0.0000 C 0 0 1.5548 -3.6021 0.0000 O 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 2.7000 0.0000 Cl 0 0 2.8542 -5.8570 0.0000 O 0 0 5.1925 -3.0070 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.3383 1.3500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 5.1924 -6.0070 0.0000 C 0 0 6.4915 -3.7571 0.0000 C 0 0 6.4915 -5.2571 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 1 0 5 4 2 0 6 2 2 0 7 1 2 0 8 5 1 0 9 8 1 0 10 6 1 0 11 2 1 0 12 4 1 0 13 5 1 0 14 12 2 0 15 14 1 0 16 6 1 0 17 11 2 0 18 17 1 0 16 18 2 0 8 15 2 0 M END > 139581 > Eur. J. Med. Chem. 39(1)-2004 11-26 > EGFR > 5.8239 $$$$ SciTegic07090714142D 18 19 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 2.5973 -1.5031 0.0000 N 0 0 2.5951 -3.0039 0.0000 C 0 0 -2.5972 -1.5031 0.0000 N 0 0 3.8915 -3.7585 0.0000 C 0 0 3.8864 -5.2585 0.0000 C 0 0 -3.8916 -4.9570 0.0000 O 0 0 1.2883 -5.2495 0.0000 C 0 0 1.2935 -3.7495 0.0000 C 0 0 -2.5951 -3.0039 0.0000 C 0 0 2.5847 -6.0040 0.0000 C 0 0 -3.8933 -3.7570 0.0000 C 0 0 4.9235 -5.8621 0.0000 C 0 0 2 1 2 0 3 5 1 0 4 1 1 0 5 4 2 0 6 2 1 0 7 1 1 0 8 7 1 0 9 5 1 0 10 8 2 0 11 10 1 0 12 17 1 0 13 14 2 0 14 8 1 0 15 9 1 0 16 13 1 0 17 15 1 0 18 11 1 0 3 6 2 0 11 16 2 0 M END > 55729 > J. Med. Chem. 42(26)-1999 5464-5474 > EGFR > 9.0000 $$$$ SciTegic07090714142D 19 20 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6078 5.9988 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 -2.7509 7.4791 0.0000 S 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -3.9571 5.3730 0.0000 C 0 0 -4.2192 7.7859 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 -4.9646 6.4842 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 5 3 0 7 4 1 0 8 11 1 0 9 3 1 0 10 16 1 0 11 9 2 0 12 4 2 0 13 7 1 0 14 2 2 0 15 12 1 0 16 17 2 0 17 9 1 0 18 8 1 0 19 10 1 0 13 15 2 0 10 8 2 0 M END > 65715 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 4.5086 $$$$ SciTegic07090714142D 19 21 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -3.8775 6.0115 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.8739 7.5115 0.0000 C 0 0 -5.1785 5.2648 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -6.4757 6.0180 0.0000 C 0 0 -5.1711 8.2648 0.0000 C 0 0 -6.4720 7.5180 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 6 1 0 5 4 2 0 6 1 1 0 7 2 1 0 8 7 1 0 9 1 2 0 10 11 1 0 11 8 1 0 12 6 2 0 13 10 2 0 14 10 1 0 15 9 1 0 16 15 2 0 17 14 2 0 18 13 1 0 19 17 1 0 16 12 1 0 5 3 1 0 18 19 2 0 M END > 25216 > J. Med. Chem. 38(18)-1995 3482-3487 > EGFR > 5.3872 $$$$ SciTegic07090714142D 19 21 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 -0.9971 3.0138 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 3.7889 0.0269 0.0000 C 0 0 -2.2878 5.2708 0.0000 C 0 0 -3.5824 6.0284 0.0000 C 0 0 -0.9844 6.0132 0.0000 C 0 0 -0.9756 7.5132 0.0000 C 0 0 -3.5736 7.5284 0.0000 C 0 0 -2.2702 8.2708 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 2 2 0 7 1 2 0 8 10 2 0 9 6 1 0 10 7 1 0 11 9 1 0 12 4 1 0 13 5 1 0 14 11 1 0 15 14 1 0 16 14 2 0 17 16 1 0 18 15 2 0 19 17 2 0 4 5 2 0 6 8 1 0 18 19 1 0 M END > 31230 > J. Med. Chem. 39(12)-1996 2285-2292 > EGFR > 5.9666 $$$$ SciTegic07090714142D 19 22 0 0 0 0 999 V2000 -1.0028 1.5132 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 -0.9971 3.0138 0.0000 N 0 0 1.7138 1.2033 0.0000 S 0 0 0.2917 -0.7475 0.0000 C 0 0 -3.6043 6.0228 0.0000 C 0 0 -6.0055 6.2720 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -4.8969 5.2715 0.0000 C 0 0 -5.3892 7.6424 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -2.2918 5.2884 0.0000 C 0 0 -3.9248 7.4813 0.0000 C 0 0 -4.9084 3.7676 0.0000 C 0 0 -3.5868 3.0174 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 2 2 0 7 16 2 0 8 12 1 0 9 5 1 0 10 6 1 0 11 14 2 0 12 18 2 0 13 17 2 0 14 3 1 0 15 4 1 0 16 15 1 0 17 7 1 0 18 19 1 0 19 15 2 0 6 11 1 0 10 9 2 0 7 12 1 0 8 13 1 0 M END > 137424 > Bioorg. Med. Chem. Lett. 14(1)-2004 21-24 > EGFR > 6.2218 $$$$ SciTegic07090714142D 20 21 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 -2.6078 5.9988 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 -2.6131 7.4988 0.0000 C 0 0 -3.9044 5.2443 0.0000 C 0 0 -3.9148 8.2443 0.0000 C 0 0 -5.2060 5.9898 0.0000 C 0 0 -5.2112 7.4898 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 4 3 0 6 9 1 0 7 3 1 0 8 12 1 0 9 7 2 0 10 2 2 0 11 2 1 0 12 13 2 0 13 7 1 0 14 6 1 0 15 8 1 0 16 11 1 0 17 11 2 0 18 16 2 0 19 17 1 0 20 19 2 0 8 6 2 0 20 18 1 0 M END > 65712 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 4.8539 $$$$ SciTegic07090714142D 20 22 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.1812 2.6271 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 3.6500 2.9355 0.0000 N 0 0 3.7889 0.0269 0.0000 S 0 0 1.3808 3.5211 0.0000 O 0 0 2.0907 -2.3426 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 5.5858 4.6718 0.0000 C 0 0 3.1158 5.4773 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 3.5808 6.9034 0.0000 C 0 0 6.0509 6.0979 0.0000 C 0 0 5.0484 7.2137 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 2 1 0 6 3 1 0 7 4 1 0 8 1 2 0 9 4 2 0 10 3 1 0 11 7 1 0 12 5 2 0 13 6 2 0 14 11 2 0 15 11 1 0 16 12 1 0 17 13 1 0 18 15 2 0 19 14 1 0 20 18 1 0 5 6 1 0 16 17 2 0 19 20 2 0 M END > 17415 > J. Med. Chem. 37(13)-1994 2033-2042 > EGFR > 6.0000 $$$$ SciTegic07090714142D 21 23 0 0 0 0 999 V2000 3.6500 2.9355 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 4.6511 1.8174 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 5.4516 0.9234 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 3.3178 5.2555 0.0000 O 0 0 5.5870 4.6698 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 6.0571 6.0943 0.0000 C 0 0 6.5858 3.5506 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 8.0544 3.8559 0.0000 C 0 0 7.5257 6.3996 0.0000 C 0 0 8.5244 5.2803 0.0000 C 0 0 2 3 1 0 3 1 2 0 4 5 1 0 5 2 2 0 6 1 1 0 7 1 1 0 8 2 1 0 9 7 3 0 10 8 2 0 11 6 2 0 12 6 1 0 13 8 1 0 14 10 1 0 15 12 2 0 16 12 1 0 17 13 2 0 18 17 1 0 19 16 2 0 20 15 1 0 21 19 1 0 10 4 1 0 20 21 2 0 18 14 2 0 M END > 31033 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 3.5229 $$$$ SciTegic07090714142D 21 23 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 3.7889 0.0269 0.0000 S 0 0 2.1812 2.6271 0.0000 C 0 0 4.1182 4.3614 0.0000 N 0 0 4.4505 2.0415 0.0000 O 0 0 5.5870 4.6698 0.0000 C 0 0 6.0553 6.0958 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 7.5228 6.4061 0.0000 C 0 0 5.0528 7.2117 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 5.5178 8.6377 0.0000 C 0 0 7.9879 7.8322 0.0000 C 0 0 6.9854 8.9480 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 8 1 0 7 1 2 0 8 3 1 0 9 6 1 0 10 6 2 0 11 9 1 0 12 11 1 0 13 5 1 0 14 4 1 0 15 12 1 0 16 12 2 0 17 13 2 0 18 14 2 0 19 16 1 0 20 15 2 0 21 19 2 0 5 4 2 0 18 17 1 0 20 21 1 0 M END > 15393 > J. Med. Chem. 37(5)-1994 598-609 > EGFR > 4.0000 $$$$ SciTegic07090714142D 21 23 0 0 0 0 999 V2000 5.5385 4.8027 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 3.2311 5.5551 0.0000 N 0 0 4.1140 6.7677 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 5.5401 6.3027 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 6.7428 3.9115 0.0000 C 0 0 4.6511 1.8174 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 7.7074 3.1977 0.0000 N 0 0 5.4516 0.9234 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 6.5117 7.0070 0.0000 N 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 2 1 0 5 7 2 0 6 8 1 0 7 1 1 0 8 3 2 0 9 10 1 0 10 6 2 0 11 1 1 0 12 3 1 0 13 6 1 0 14 11 3 0 15 12 3 0 16 13 2 0 17 7 1 0 18 13 1 0 19 16 1 0 20 18 2 0 21 20 1 0 4 5 1 0 16 9 1 0 21 19 2 0 M END > 31035 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 4.0000 $$$$ SciTegic07090714142D 21 22 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 -2.6078 5.9988 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.6109 7.4996 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 -3.9100 8.2496 0.0000 C 0 0 -1.3119 8.2497 0.0000 C 0 0 -1.3119 9.7497 0.0000 C 0 0 -3.9100 9.7496 0.0000 C 0 0 -2.6110 10.4997 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 4 3 0 6 2 1 0 7 11 1 0 8 3 1 0 9 12 1 0 10 2 2 0 11 8 2 0 12 14 2 0 13 6 1 0 14 8 1 0 15 7 1 0 16 9 1 0 17 13 2 0 18 13 1 0 19 18 2 0 20 17 1 0 21 19 1 0 7 9 2 0 20 21 2 0 M END > 31026 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 5.0000 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 -1.2274 -0.6045 0.0000 C 0 0 0.0000 -1.3190 0.0000 N 0 0 -1.2274 0.8244 0.0000 C 0 0 1.2274 0.8244 0.0000 C 0 0 1.2274 -0.6045 0.0000 C 0 0 -2.4915 -1.3190 0.0000 C 0 0 -3.7006 -0.6045 0.0000 N 0 0 -2.4915 1.5389 0.0000 N 0 0 -2.5225 -2.8202 0.0000 N 0 0 -3.7006 0.8244 0.0000 C 0 0 -3.8372 -3.5442 0.0000 C 0 0 2.4732 1.5389 0.0000 C 0 0 -3.8685 -5.0447 0.0000 C 0 0 2.4732 -1.3190 0.0000 C 0 0 -5.1815 -5.7702 0.0000 C 0 0 -2.5838 -5.8191 0.0000 C 0 0 3.7372 0.8244 0.0000 C 0 0 3.7372 -0.6045 0.0000 C 0 0 -2.6121 -7.3188 0.0000 C 0 0 -5.2097 -7.2699 0.0000 C 0 0 -3.9250 -8.0442 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 2 1 0 6 1 1 0 7 6 2 0 8 3 1 0 9 6 1 0 10 7 1 0 11 9 1 0 12 4 1 0 13 11 1 0 14 5 1 0 15 13 1 0 16 13 2 0 17 12 2 0 18 14 2 0 19 16 1 0 20 15 2 0 21 19 2 0 4 5 2 0 8 10 2 0 18 17 1 0 20 21 1 0 M END > 55744 > J. Med. Chem. 42(26)-1999 5464-5474 > EGFR > 6.3372 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 -1.2274 0.8244 0.0000 C 0 0 -1.2274 -0.6045 0.0000 C 0 0 -2.4915 1.5389 0.0000 C 0 0 0.0000 -1.3190 0.0000 N 0 0 1.2274 0.8244 0.0000 C 0 0 1.2274 -0.6045 0.0000 C 0 0 -2.4915 -1.3190 0.0000 N 0 0 -3.7006 0.8244 0.0000 N 0 0 -2.5225 3.0401 0.0000 N 0 0 -3.7006 -0.6045 0.0000 C 0 0 -3.8372 3.7640 0.0000 C 0 0 -3.8705 5.2637 0.0000 C 0 0 -5.1859 5.9847 0.0000 C 0 0 2.4732 1.5389 0.0000 C 0 0 2.4732 -1.3190 0.0000 C 0 0 -5.2124 7.1844 0.0000 O 0 0 -6.4347 3.7065 0.0000 C 0 0 -5.1194 2.9855 0.0000 C 0 0 -6.4680 5.2061 0.0000 C 0 0 3.7372 0.8244 0.0000 C 0 0 3.7372 -0.6045 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 5 2 0 7 2 2 0 8 3 1 0 9 3 1 0 10 8 2 0 11 9 1 0 12 11 1 0 13 12 2 0 14 5 1 0 15 6 1 0 16 13 1 0 17 18 1 0 18 11 2 0 19 17 2 0 20 14 1 0 21 20 1 0 6 4 1 0 7 10 1 0 21 15 1 0 13 19 1 0 M END > 31236 > J. Med. Chem. 39(12)-1996 2285-2292 > EGFR > 6.3768 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 -0.6588 -1.3543 0.0000 C 0 0 -1.9399 -2.0863 0.0000 C 0 0 -0.6588 0.1464 0.0000 C 0 0 0.6405 0.8968 0.0000 C 0 0 -3.2576 -1.3543 0.0000 N 0 0 3.0746 1.1530 0.0000 N 0 0 0.9517 2.3608 0.0000 N 0 0 -1.9251 -3.5874 0.0000 N 0 0 2.4524 2.5256 0.0000 C 0 0 1.9399 0.1464 0.0000 C 0 0 0.6405 -2.0863 0.0000 C 0 0 -1.9399 0.8968 0.0000 N 0 0 -3.2576 0.1464 0.0000 C 0 0 -3.2167 -4.3517 0.0000 C 0 0 1.9399 -1.3543 0.0000 C 0 0 -3.2040 -5.8516 0.0000 C 0 0 -4.4966 -6.6127 0.0000 C 0 0 -4.4864 -7.8126 0.0000 Br 0 0 -5.8148 -4.3738 0.0000 C 0 0 -4.5222 -3.6128 0.0000 C 0 0 -5.8020 -5.8738 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 2 0 6 10 1 0 7 4 1 0 8 2 1 0 9 7 1 0 10 15 2 0 11 1 2 0 12 3 1 0 13 12 2 0 14 8 1 0 15 11 1 0 16 14 2 0 17 16 1 0 18 17 1 0 19 20 2 0 20 14 1 0 21 19 1 0 4 10 1 0 13 5 1 0 6 9 2 0 17 21 2 0 M END > 29273 > J. Med. Chem. 39(4)-1996 918-928 > EGFR > 6.5654 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 -1.9399 0.8968 0.0000 C 0 0 -0.6588 0.1464 0.0000 C 0 0 0.6405 0.8968 0.0000 C 0 0 -3.2576 0.1464 0.0000 N 0 0 3.0746 1.1530 0.0000 N 0 0 -1.9253 2.3975 0.0000 N 0 0 0.9517 2.3608 0.0000 N 0 0 2.4524 2.5256 0.0000 C 0 0 1.9399 0.1464 0.0000 C 0 0 -0.6588 -1.3543 0.0000 C 0 0 -1.9399 -2.0863 0.0000 N 0 0 -3.2576 -1.3543 0.0000 C 0 0 -3.2171 3.1615 0.0000 C 0 0 -3.2046 4.6615 0.0000 C 0 0 1.9399 -1.3543 0.0000 C 0 0 0.6405 -2.0863 0.0000 C 0 0 -4.4973 5.4224 0.0000 C 0 0 -4.4872 6.6223 0.0000 Br 0 0 -5.8152 3.1833 0.0000 C 0 0 -4.5225 2.4225 0.0000 C 0 0 -5.8026 4.6833 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 1 2 0 5 9 1 0 6 1 1 0 7 3 1 0 8 7 1 0 9 3 1 0 10 2 1 0 11 12 2 0 12 4 1 0 13 6 1 0 14 13 2 0 15 16 1 0 16 10 2 0 17 14 1 0 18 17 1 0 19 20 2 0 20 13 1 0 21 19 1 0 10 11 1 0 15 9 2 0 8 5 2 0 17 21 2 0 M END > 29272 > J. Med. Chem. 39(4)-1996 918-928 > EGFR > 7.5376 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 -1.2274 -0.6045 0.0000 C 0 0 0.0000 -1.3190 0.0000 S 0 0 -1.2274 0.8244 0.0000 C 0 0 1.2274 0.8244 0.0000 C 0 0 -2.4915 -1.3190 0.0000 C 0 0 1.2274 -0.6045 0.0000 C 0 0 -3.7006 -0.6045 0.0000 N 0 0 -2.5225 -2.8202 0.0000 N 0 0 -2.4915 1.5389 0.0000 N 0 0 2.4732 1.5389 0.0000 C 0 0 -3.7006 0.8244 0.0000 C 0 0 2.4732 -1.3190 0.0000 C 0 0 3.7372 0.8244 0.0000 C 0 0 -3.8372 -3.5442 0.0000 C 0 0 4.7737 1.4291 0.0000 N 0 0 3.7372 -0.6045 0.0000 C 0 0 -3.8705 -5.0438 0.0000 C 0 0 -5.1194 -2.7656 0.0000 C 0 0 -6.4347 -3.4867 0.0000 C 0 0 -5.1859 -5.7649 0.0000 C 0 0 -6.4680 -4.9863 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 1 1 0 6 2 1 0 7 5 2 0 8 5 1 0 9 3 1 0 10 4 1 0 11 7 1 0 12 6 1 0 13 10 2 0 14 8 1 0 15 13 1 0 16 12 2 0 17 14 1 0 18 14 2 0 19 18 1 0 20 17 2 0 21 19 2 0 4 6 2 0 9 11 2 0 16 13 1 0 21 20 1 0 M END > 55765 > J. Med. Chem. 42(26)-1999 5464-5474 > EGFR > 8.0269 $$$$ SciTegic07090714142D 21 24 0 0 0 0 999 V2000 1.9924 -0.6682 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 3.3044 -1.4214 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.0045 1.2999 0.0000 N 0 0 -0.5831 -0.6682 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -2.0045 -1.1298 0.0000 N 0 0 0.7168 1.5915 0.0000 C 0 0 4.6043 -0.6682 0.0000 N 0 0 3.3133 -2.9221 0.0000 N 0 0 3.3044 1.5915 0.0000 N 0 0 4.6043 0.8382 0.0000 C 0 0 4.6171 -3.6655 0.0000 C 0 0 4.6282 -5.1655 0.0000 C 0 0 5.9328 -5.9059 0.0000 C 0 0 5.9416 -7.1059 0.0000 Br 0 0 7.2152 -3.6464 0.0000 C 0 0 5.9107 -2.9060 0.0000 C 0 0 7.2263 -5.1464 0.0000 C 0 0 2 9 1 0 3 1 1 0 4 10 1 0 5 4 1 0 6 7 1 0 7 1 2 0 8 1 1 0 9 6 1 0 10 8 2 0 11 3 2 0 12 3 1 0 13 8 1 0 14 13 2 0 15 12 1 0 16 15 2 0 17 16 1 0 18 17 1 0 19 20 2 0 20 15 1 0 21 19 1 0 6 4 2 0 11 14 1 0 2 5 2 0 17 21 2 0 M END > 29274 > J. Med. Chem. 39(4)-1996 918-928 > EGFR > 8.3872 $$$$ SciTegic07090714142D 22 24 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 3.7889 0.0269 0.0000 S 0 0 2.1812 2.6271 0.0000 C 0 0 4.1182 4.3614 0.0000 C 0 0 5.5870 4.6698 0.0000 N 0 0 3.3178 5.2555 0.0000 O 0 0 3.6500 2.9355 0.0000 C 0 0 6.0553 6.0958 0.0000 C 0 0 7.5241 6.4042 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 7.9941 7.8286 0.0000 C 0 0 8.5228 5.2849 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 9.9914 5.5902 0.0000 C 0 0 9.4627 8.1339 0.0000 C 0 0 10.4614 7.0146 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 1 2 0 7 3 1 0 8 11 1 0 9 8 1 0 10 8 2 0 11 7 1 0 12 9 1 0 13 12 1 0 14 5 1 0 15 4 1 0 16 13 2 0 17 13 1 0 18 14 2 0 19 15 2 0 20 17 2 0 21 16 1 0 22 20 1 0 5 4 2 0 19 18 1 0 21 22 2 0 M END > 15395 > J. Med. Chem. 37(5)-1994 598-609 > EGFR > 4.0000 $$$$ SciTegic07090714142D 22 25 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 4.0872 0.0320 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 S 0 0 6.3513 -1.2462 0.0000 C 0 0 4.8506 -1.2602 0.0000 C 0 0 8.6126 -0.4760 0.0000 N 0 0 7.1754 -0.0372 0.0000 C 0 0 4.8251 1.3389 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 7.2188 -2.4471 0.0000 C 0 0 5.4151 2.3839 0.0000 N 0 0 8.6353 -1.9691 0.0000 C 0 0 6.9070 -3.9184 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 9.7747 -2.9509 0.0000 C 0 0 8.0522 -4.9174 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 9.4688 -4.4395 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 6 1 0 6 2 2 0 7 8 1 0 8 5 2 0 9 2 1 0 10 3 1 0 11 4 1 0 12 5 1 0 13 9 3 0 14 12 2 0 15 12 1 0 16 10 1 0 17 11 1 0 18 14 1 0 19 15 2 0 20 16 2 0 21 17 2 0 22 19 1 0 10 11 2 0 21 20 1 0 14 7 1 0 18 22 2 0 M END > 31036 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 4.0000 $$$$ SciTegic07090714142D 22 24 0 0 1 0 999 V2000 -1.2964 1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -3.9122 1.4966 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 1 0 0 0 3.8911 1.5017 0.0000 O 0 0 3.8911 -1.5017 0.0000 O 0 0 -7.8042 -0.7641 0.0000 C 0 0 2 0 0 0 -6.5125 1.4901 0.0000 C 0 0 -5.2061 -0.7556 0.0000 C 0 0 -6.5027 -1.5098 0.0000 C 0 0 -7.8091 0.7359 0.0000 C 0 0 -8.8414 -1.3675 0.0000 O 0 0 3.8894 2.7017 0.0000 C 0 0 3.8894 -2.7017 0.0000 C 0 0 2 1 1 0 3 11 2 0 4 2 2 0 5 2 1 0 6 1 2 0 7 5 2 0 8 4 1 0 9 7 1 0 10 6 1 0 11 6 1 0 12 10 1 6 13 8 1 0 14 9 1 0 15 18 1 0 16 12 1 0 17 12 1 0 18 17 1 0 19 16 1 0 15 20 1 1 21 13 1 0 22 14 1 0 3 5 1 0 9 8 2 0 15 19 1 0 M END > 119739 > Bioorg. Med. Chem. Lett. 13(18)-2003 3097-3100 > EGFR > 5.4318 $$$$ SciTegic07090714142D 22 23 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 -2.6078 5.9988 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.6109 7.4996 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 -3.9118 8.2481 0.0000 C 0 0 -3.9171 9.7482 0.0000 C 0 0 -5.2083 7.4937 0.0000 C 0 0 -6.5099 8.2392 0.0000 C 0 0 -5.2187 10.4937 0.0000 C 0 0 -6.5151 9.7392 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 4 3 0 6 2 1 0 7 10 1 0 8 3 1 0 9 12 1 0 10 8 2 0 11 2 2 0 12 14 2 0 13 6 1 0 14 8 1 0 15 7 1 0 16 9 1 0 17 13 1 0 18 17 2 0 19 17 1 0 20 19 2 0 21 18 1 0 22 20 1 0 9 7 2 0 22 21 2 0 M END > 65729 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 5.6990 $$$$ SciTegic07090714142D 22 25 0 0 0 0 999 V2000 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 2.1852 -2.6281 0.0000 C 0 0 2.1749 2.6315 0.0000 C 0 0 -0.9991 2.7132 0.0000 N 0 0 3.6221 -3.0405 0.0000 C 0 0 1.1007 -3.6669 0.0000 C 0 0 1.2517 3.8078 0.0000 C 0 0 3.6621 2.8384 0.0000 C 0 0 4.2218 4.2301 0.0000 C 0 0 1.8114 5.1995 0.0000 C 0 0 1.4624 -5.1227 0.0000 C 0 0 3.9838 -4.4963 0.0000 C 0 0 3.2965 5.4106 0.0000 C 0 0 2.9039 -5.5373 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 3 2 0 6 2 1 0 7 4 1 0 8 9 1 0 9 6 2 0 10 1 1 0 11 5 1 0 12 7 1 0 13 10 1 0 14 10 2 0 15 11 1 0 16 11 2 0 17 16 1 0 18 15 2 0 19 14 1 0 20 13 2 0 21 17 2 0 22 19 2 0 4 5 1 0 22 20 1 0 8 7 2 0 21 18 1 0 M END > 39522 > J. Med. Chem. 40(22)-1997 3601-3616 > EGFR > 6.0969 $$$$ SciTegic07090714142D 22 25 0 0 0 0 999 V2000 -1.2989 0.7501 0.0000 C 0 0 -2.5978 1.5002 0.0000 C 0 0 -1.2989 -0.7501 0.0000 C 0 0 0.0000 1.5002 0.0000 C 0 0 -3.8968 0.7501 0.0000 N 0 0 0.0000 -1.5002 0.0000 C 0 0 -2.6009 3.0010 0.0000 N 0 0 1.2806 0.7501 0.0000 C 0 0 1.2806 -0.7501 0.0000 C 0 0 -2.5978 -1.5002 0.0000 N 0 0 -3.8968 -0.7501 0.0000 C 0 0 2.5978 1.5002 0.0000 N 0 0 2.5978 -1.5002 0.0000 N 0 0 -3.9017 3.7496 0.0000 C 0 0 -3.9070 5.2496 0.0000 C 0 0 -5.2086 5.9951 0.0000 C 0 0 -5.2128 7.1951 0.0000 Br 0 0 -6.4999 3.7406 0.0000 C 0 0 3.8968 -0.7501 0.0000 C 0 0 3.8968 0.7501 0.0000 C 0 0 -5.1983 2.9951 0.0000 C 0 0 -6.5051 5.2406 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 1 2 0 5 2 2 0 6 3 2 0 7 2 1 0 8 4 1 0 9 8 2 0 10 3 1 0 11 10 2 0 12 8 1 0 13 9 1 0 14 7 1 0 15 14 2 0 16 15 1 0 17 16 1 0 18 21 2 0 19 20 1 0 20 12 2 0 21 14 1 0 22 18 1 0 6 9 1 0 11 5 1 0 19 13 2 0 16 22 2 0 M END > 29281 > J. Med. Chem. 39(4)-1996 918-928 > EGFR > 8.7696 $$$$ SciTegic07090714142D 23 26 0 0 0 0 999 V2000 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 8.0566 3.8517 0.0000 N 0 0 6.5873 3.5462 0.0000 C 0 0 3.7889 0.0269 0.0000 O 0 0 3.6500 2.9355 0.0000 C 0 0 5.5886 4.6654 0.0000 C 0 0 6.1174 2.1217 0.0000 C 0 0 4.1200 4.3600 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 9.0572 2.7341 0.0000 C 0 0 8.5244 5.2769 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 9.9925 5.5846 0.0000 C 0 0 10.5254 3.0417 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 10.9930 4.4670 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 1 0 5 4 1 0 6 1 2 0 7 8 1 0 8 12 2 0 9 2 2 0 10 6 1 0 11 13 2 0 12 14 1 0 13 10 1 0 14 10 2 0 15 7 1 0 16 7 1 0 17 4 2 0 18 5 2 0 19 16 1 0 20 15 1 0 21 17 1 0 22 21 2 0 23 19 1 0 5 3 1 0 11 8 1 0 18 22 1 0 20 23 1 0 M END > 44730 > J. Med. Chem. 41(14)-1998 2588-2603 > EGFR > 4.0334 $$$$ SciTegic07090714142D 23 24 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 5.2003 -1.4932 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -1.3087 5.2502 0.0000 C 0 0 -2.6031 2.9979 0.0000 C 0 0 6.5517 -0.8722 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -3.6418 2.3971 0.0000 N 0 0 5.3382 -2.9741 0.0000 S 0 0 1.2990 0.7500 0.0000 C 0 0 3.8990 -0.7455 0.0000 S 0 0 -1.2990 0.7500 0.0000 C 0 0 2.6003 -1.4977 0.0000 C 0 0 -2.3494 5.8476 0.0000 O 0 0 -0.2712 5.8532 0.0000 N 0 0 0.0000 -2.7000 0.0000 O 0 0 -2.6003 -1.4978 0.0000 O 0 0 7.5554 -1.9869 0.0000 C 0 0 6.8054 -3.2859 0.0000 C 0 0 -3.6387 -0.8963 0.0000 C 0 0 2 14 1 0 3 13 2 0 4 1 2 0 5 1 1 0 6 1 1 0 7 2 2 0 8 9 2 0 9 15 1 0 10 4 1 0 11 6 3 0 12 2 1 0 13 10 1 0 14 16 1 0 15 10 2 0 16 3 1 0 17 5 2 0 18 5 1 0 19 8 1 0 20 9 1 0 21 7 1 0 22 12 1 0 23 20 1 0 8 3 1 0 21 22 1 0 M END > 73107 > J. Med. Chem. 36(23)-1993 3556-3564 > EGFR > 4.7878 $$$$ SciTegic07090714142D 23 25 0 0 0 0 999 V2000 -4.9153 0.7255 0.0000 C 0 0 -6.2216 1.4644 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 -7.5151 0.7033 0.0000 C 0 0 -4.9025 -0.7753 0.0000 C 0 0 -4.8922 -1.9753 0.0000 N 0 0 -8.8219 1.4399 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 -10.1132 0.6766 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -10.0978 -0.8233 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 -6.2318 2.6643 0.0000 O 0 0 -7.4999 -0.7967 0.0000 C 0 0 -8.7911 -1.5600 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -11.1585 1.2659 0.0000 O 0 0 -11.1308 -1.4339 0.0000 O 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 5 3 0 7 4 1 0 8 15 1 0 9 11 1 0 10 7 2 0 11 20 1 0 12 16 2 0 13 3 1 0 14 19 2 0 15 13 2 0 16 8 1 0 17 2 2 0 18 4 2 0 19 18 1 0 20 21 2 0 21 13 1 0 22 10 1 0 23 14 1 0 8 11 2 0 14 10 1 0 12 9 1 0 M END > 31029 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 5.0000 $$$$ SciTegic07090714142D 23 24 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 -2.6078 5.9988 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 -2.6109 7.4996 0.0000 C 0 0 -3.9149 9.7490 0.0000 C 0 0 -3.9118 8.2481 0.0000 C 0 0 -5.2139 10.4990 0.0000 C 0 0 -2.6158 10.4991 0.0000 C 0 0 -2.6159 11.9991 0.0000 C 0 0 -5.2139 11.9990 0.0000 C 0 0 -3.9149 12.7491 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 4 3 0 6 9 1 0 7 3 1 0 8 12 1 0 9 7 2 0 10 2 2 0 11 2 1 0 12 13 2 0 13 7 1 0 14 6 1 0 15 8 1 0 16 11 1 0 17 18 1 0 18 16 1 0 19 17 1 0 20 17 2 0 21 20 1 0 22 19 2 0 23 21 2 0 8 6 2 0 23 22 1 0 M END > 65722 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 6.0315 $$$$ SciTegic07090714142D 24 26 0 0 0 0 999 V2000 -4.9153 0.7255 0.0000 C 0 0 -6.2216 1.4644 0.0000 C 0 0 -7.5151 0.7033 0.0000 N 0 0 -3.6217 1.4865 0.0000 C 0 0 -4.9025 -0.7753 0.0000 C 0 0 -4.8922 -1.9753 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -8.8215 1.4422 0.0000 C 0 0 -6.2318 2.6643 0.0000 O 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -10.1150 0.6811 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -8.8317 2.6421 0.0000 C 0 0 -11.4218 1.4177 0.0000 C 0 0 -10.0997 -0.8189 0.0000 C 0 0 -11.3910 -1.5821 0.0000 C 0 0 -12.7130 0.6544 0.0000 C 0 0 -12.6977 -0.8455 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 1 1 0 6 5 3 0 7 14 1 0 8 9 1 0 9 16 1 0 10 15 2 0 11 4 1 0 12 3 1 0 13 2 2 0 14 11 2 0 15 7 1 0 16 18 2 0 17 12 1 0 18 11 1 0 19 12 1 0 20 17 1 0 21 17 2 0 22 21 1 0 23 20 2 0 24 22 2 0 7 9 2 0 10 8 1 0 23 24 1 0 M END > 31028 > J. Med. Chem. 39(11)-1996 2170-2177 > EGFR > 5.0000 $$$$ SciTegic07090714142D 24 26 0 0 0 0 999 V2000 2.5973 -1.5031 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 2.5951 -3.0039 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 2.5972 1.5031 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 6.4914 5.2571 0.0000 N 0 0 3.8933 -3.7570 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 6.4915 -5.2571 0.0000 C 0 0 7.5307 -5.8571 0.0000 Cl 0 0 0.0000 -1.5000 0.0000 C 0 0 3.8934 -5.2570 0.0000 C 0 0 5.1925 -3.0070 0.0000 C 0 0 6.4915 -3.7571 0.0000 C 0 0 5.1924 -6.0070 0.0000 C 0 0 3.8933 3.7570 0.0000 C 0 0 5.1924 6.0071 0.0000 C 0 0 6.4915 3.7571 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.8933 5.2570 0.0000 C 0 0 5.1925 3.0071 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 4 1 0 6 1 2 0 7 19 1 0 8 3 1 0 9 5 1 0 10 15 2 0 11 10 1 0 12 2 1 0 13 8 1 0 14 8 2 0 15 14 1 0 16 13 2 0 17 9 1 0 18 21 1 0 19 22 2 0 20 4 1 0 21 17 2 0 22 17 1 0 23 12 2 0 24 23 1 0 10 16 1 0 24 20 2 0 7 18 2 0 M END > 119311 > Bioorg. Med. Chem. Lett. 13(16)-2003 2967-2971 > EGFR > 5.1367 $$$$ SciTegic07090714142D 24 26 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 3.8933 -3.7570 0.0000 C 0 0 2.5951 -3.0039 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 4.9336 -3.1588 0.0000 O 0 0 2.5973 -1.5031 0.0000 C 0 0 -1.2990 0.7500 0.0000 O 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 3.8787 -9.7587 0.0000 O 0 0 3.8808 -8.2579 0.0000 C 0 0 5.1769 -10.5118 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 5.1748 -12.0126 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 6.4713 -12.7672 0.0000 C 0 0 3.8732 -12.7582 0.0000 C 0 0 3.8680 -14.2582 0.0000 C 0 0 6.4661 -14.2671 0.0000 C 0 0 5.1645 -15.0127 0.0000 C 0 0 2 3 1 0 3 6 1 0 4 2 1 0 5 2 2 0 6 1 1 0 7 18 1 0 8 4 1 0 9 4 2 0 10 11 1 0 11 14 2 0 12 10 1 0 13 8 2 0 14 9 1 0 15 12 1 0 16 1 1 0 17 1 1 0 18 17 1 0 19 16 1 0 20 15 2 0 21 15 1 0 22 21 2 0 23 20 1 0 24 22 1 0 19 7 1 0 13 11 1 0 23 24 2 0 M END > 23718 > J. Med. Chem. 38(13)-1995 2441-2448 > EGFR > 5.8239 $$$$ SciTegic07090714142D 24 26 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 2.5951 -3.0039 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -2.5987 1.5004 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 3.8933 -3.7570 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 3.8934 -5.2570 0.0000 C 0 0 -2.6012 3.0004 0.0000 C 0 0 -3.8967 0.7484 0.0000 C 0 0 2.3383 1.3500 0.0000 O 0 0 5.1924 -6.0070 0.0000 C 0 0 -5.1993 2.9963 0.0000 C 0 0 -6.2395 3.5946 0.0000 N 0 0 -3.9015 3.7484 0.0000 C 0 0 -5.1969 1.4963 0.0000 C 0 0 5.1924 -7.2070 0.0000 O 0 0 6.4915 -3.7571 0.0000 C 0 0 5.1925 -3.0070 0.0000 C 0 0 6.4915 -5.2571 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 1 1 0 6 3 1 0 7 11 1 0 8 7 1 0 9 2 2 0 10 4 1 0 11 5 2 0 12 10 2 0 13 8 2 0 14 8 1 0 15 3 1 0 16 12 1 0 17 20 1 0 18 17 1 0 19 13 1 0 20 14 2 0 21 16 1 0 22 23 2 0 23 10 1 0 24 22 1 0 6 7 2 0 19 17 2 0 16 24 2 0 M END > 139589 > Eur. J. Med. Chem. 39(1)-2004 11-26 > EGFR > 6.0000 $$$$ SciTegic07090714142D 24 27 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 -0.9971 3.0138 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 2.1749 2.6315 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -2.2901 5.2700 0.0000 C 0 0 1.2517 3.8078 0.0000 C 0 0 3.6621 2.8384 0.0000 C 0 0 -3.5873 6.0231 0.0000 C 0 0 3.2965 5.4106 0.0000 C 0 0 3.7442 6.5239 0.0000 N 0 0 1.8114 5.1995 0.0000 C 0 0 4.2218 4.2301 0.0000 C 0 0 -3.5845 7.2231 0.0000 Cl 0 0 -4.8917 3.7761 0.0000 C 0 0 -3.5944 3.0231 0.0000 C 0 0 -4.8881 5.2761 0.0000 C 0 0 2 4 2 0 3 1 2 0 4 1 1 0 5 6 1 0 6 1 1 0 7 3 1 0 8 3 1 0 9 6 2 0 10 4 1 0 11 9 1 0 12 8 1 0 13 12 1 0 14 10 2 0 15 10 1 0 16 13 2 0 17 20 1 0 18 17 1 0 19 14 1 0 20 15 2 0 21 16 1 0 22 23 1 0 23 12 2 0 24 22 2 0 5 2 1 0 7 11 2 0 17 19 2 0 24 16 1 0 M END > 39548 > J. Med. Chem. 40(22)-1997 3601-3616 > EGFR > 6.0969 $$$$ SciTegic07090714142D 24 25 0 0 0 0 999 V2000 -1.3039 3.7494 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 -0.0031 3.0008 0.0000 C 0 0 -2.6024 2.9967 0.0000 C 0 0 -3.6405 2.3949 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -0.2688 5.8520 0.0000 O 0 0 -2.6078 5.9988 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 -5.2157 10.4975 0.0000 C 0 0 -2.6109 7.4996 0.0000 C 0 0 -3.9149 9.7490 0.0000 C 0 0 -5.2210 11.9975 0.0000 C 0 0 -6.5122 9.7430 0.0000 C 0 0 -3.9118 8.2481 0.0000 C 0 0 -6.5226 12.7430 0.0000 C 0 0 -7.8138 10.4885 0.0000 C 0 0 -7.8190 11.9885 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 4 3 0 6 9 1 0 7 3 1 0 8 12 1 0 9 7 2 0 10 2 2 0 11 2 1 0 12 13 2 0 13 7 1 0 14 6 1 0 15 8 1 0 16 18 1 0 17 11 1 0 18 21 1 0 19 16 1 0 20 16 2 0 21 17 1 0 22 19 2 0 23 20 1 0 24 23 2 0 8 6 2 0 24 22 1 0 M END > 65719 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 6.1549 $$$$ SciTegic07090714142D 25 27 0 0 0 0 999 V2000 -3.3372 5.2929 0.0000 N 0 0 -1.8372 5.2877 0.0000 C 0 0 -1.3786 3.8595 0.0000 N 0 0 -4.2161 6.5062 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 -3.8056 3.8679 0.0000 N 0 0 2.5988 -1.5004 0.0000 S 0 0 -5.7091 6.3524 0.0000 C 0 0 -6.6911 7.4693 0.0000 C 0 0 -6.4373 5.0556 0.0000 S 0 0 1.2990 -0.7500 0.0000 C 0 0 -2.5973 1.5031 0.0000 N 0 0 3.6384 -0.9011 0.0000 O 0 0 2.5984 -2.7004 0.0000 O 0 0 -3.7262 7.6017 0.0000 O 0 0 -7.9045 5.3674 0.0000 C 0 0 3.6377 -2.1009 0.0000 N 0 0 -8.0614 6.8592 0.0000 C 0 0 -1.1285 6.2561 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -6.4346 8.6416 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 1 1 0 5 6 2 0 6 1 1 0 7 11 1 0 8 4 1 0 9 8 2 0 10 8 1 0 11 21 1 0 12 5 1 0 13 7 2 0 14 7 2 0 15 4 2 0 16 10 1 0 17 7 1 0 18 9 1 0 19 2 1 0 20 23 1 0 21 24 2 0 22 12 1 0 23 22 2 0 24 22 1 0 25 9 1 0 5 3 1 0 16 18 2 0 20 11 2 0 M END > 152670 > J. Med. Chem. 48(13)-2005 4208-4211 > EGFR > 5.0757 $$$$ SciTegic07090714142D 25 27 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 0.0000 -3.0008 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 2.5972 1.5031 0.0000 N 0 0 -1.2990 0.7500 0.0000 N 0 0 1.3026 -5.2488 0.0000 N 0 0 -1.2978 -3.7529 0.0000 C 0 0 2.5951 3.0039 0.0000 C 0 0 3.8915 3.7585 0.0000 C 0 0 -1.2955 -5.2529 0.0000 C 0 0 1.3002 -3.7488 0.0000 C 0 0 3.8863 5.2585 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -2.5925 -6.0081 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 4.9235 5.8621 0.0000 Cl 0 0 0.0048 -6.0009 0.0000 C 0 0 -3.8849 -8.2641 0.0000 C 0 0 -4.9175 -10.3687 0.0000 O 0 0 1.2883 5.2495 0.0000 C 0 0 -2.5879 -7.5089 0.0000 C 0 0 1.2934 3.7495 0.0000 C 0 0 -3.8804 -9.7649 0.0000 C 0 0 2.5847 6.0040 0.0000 C 0 0 2 4 1 0 3 1 1 0 4 1 2 0 5 3 1 0 6 16 2 0 7 12 2 0 8 2 2 0 9 5 1 0 10 9 1 0 11 8 1 0 12 2 1 0 13 10 2 0 14 3 2 0 15 11 1 0 16 4 1 0 17 13 1 0 18 7 1 0 19 22 1 0 20 24 1 0 21 23 1 0 22 15 1 0 23 9 2 0 24 19 1 0 25 21 2 0 14 6 1 0 11 18 2 0 13 25 1 0 M END > 154023 > J. Med. Chem. 48(15)-2005 4892-4909 > EGFR > 5.8665 $$$$ SciTegic07090714142D 26 28 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 -0.7500 0.0000 N 0 0 3.8933 -3.7570 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 1.2941 -3.7521 0.0000 C 0 0 0.2538 -4.3502 0.0000 N 0 0 5.1824 -7.5124 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 5.1876 -6.0124 0.0000 C 0 0 -2.5987 1.5004 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 6.2196 -8.1160 0.0000 O 0 0 3.8767 -9.4579 0.0000 O 0 0 -2.6012 3.0004 0.0000 C 0 0 -3.8967 0.7484 0.0000 C 0 0 -5.1969 1.4963 0.0000 C 0 0 -3.9015 3.7484 0.0000 C 0 0 -5.1993 2.9963 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 13 1 0 6 1 1 0 7 6 3 0 8 16 1 0 9 4 1 0 10 2 2 0 11 3 1 0 12 3 1 0 13 12 1 0 14 11 1 0 15 18 1 0 16 9 2 0 17 5 1 0 18 19 2 0 19 9 1 0 20 8 1 0 21 15 1 0 22 17 2 0 23 17 1 0 24 23 2 0 25 22 1 0 26 24 1 0 5 14 1 0 15 8 2 0 26 25 2 0 M END > 65731 > J. Med. Chem. 34(6)-1991 1896-1907 > EGFR > 4.2596 $$$$ SciTegic07090714142D 26 28 0 0 0 0 999 V2000 10.8256 1.3998 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 S 0 0 6.3513 -1.2462 0.0000 C 0 0 9.3248 1.3850 0.0000 C 0 0 11.5654 2.7057 0.0000 C 0 0 11.5897 0.1081 0.0000 C 0 0 7.1161 -2.5366 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 8.6160 -2.5196 0.0000 C 0 0 8.5865 0.0783 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 12.2006 -0.9248 0.0000 N 0 0 4.0872 0.0320 0.0000 S 0 0 7.0866 0.0613 0.0000 C 0 0 9.3512 -1.2122 0.0000 C 0 0 4.8506 -1.2602 0.0000 C 0 0 12.7653 2.7163 0.0000 O 0 0 10.9565 3.7398 0.0000 N 0 0 9.2277 -3.5520 0.0000 O 0 0 6.5280 -3.5826 0.0000 O 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 15 1 0 3 2 2 0 4 2 1 0 5 16 2 0 6 1 2 0 7 1 1 0 8 1 1 0 9 11 2 0 10 3 1 0 11 17 1 0 12 6 1 0 13 4 1 0 14 8 3 0 15 18 1 0 16 12 1 0 17 12 2 0 18 5 1 0 19 7 2 0 20 7 1 0 21 11 1 0 22 9 1 0 23 10 1 0 24 13 1 0 25 23 2 0 26 24 2 0 5 9 1 0 13 10 2 0 25 26 1 0 M END > 73102 > J. Med. Chem. 36(23)-1993 3556-3564 > EGFR > 5.1871 $$$$ SciTegic07090714142D 26 28 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 -5.2003 -1.4932 0.0000 C 0 0 2.5951 -3.0039 0.0000 O 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -6.4994 -0.7433 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 -5.2004 -2.9933 0.0000 C 0 0 -3.8990 -0.7455 0.0000 C 0 0 -2.6003 -1.4978 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -7.7985 -1.4932 0.0000 C 0 0 -6.4995 -3.7433 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -7.7985 -2.9932 0.0000 C 0 0 2.3383 1.3500 0.0000 O 0 0 -6.4994 0.4567 0.0000 O 0 0 -6.4995 -4.9433 0.0000 O 0 0 3.8934 -5.2570 0.0000 C 0 0 5.1925 -3.0070 0.0000 C 0 0 6.4915 -3.7571 0.0000 C 0 0 5.1924 -6.0070 0.0000 C 0 0 6.4915 -5.2571 0.0000 C 0 0 2 1 1 0 3 10 1 0 4 2 1 0 5 1 2 0 6 1 1 0 7 3 2 0 8 2 2 0 9 3 1 0 10 11 1 0 11 12 1 0 12 6 2 0 13 5 1 0 14 7 1 0 15 9 2 0 16 4 1 0 17 12 1 0 18 15 1 0 19 5 1 0 20 7 1 0 21 15 1 0 22 16 2 0 23 16 1 0 24 23 2 0 25 22 1 0 26 24 1 0 13 17 2 0 25 26 2 0 14 18 2 0 M END > 15837 > J. Med. Chem. 37(6)-1994 845-859 > EGFR > 7.1549 $$$$ SciTegic07090714142D 26 29 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 6.3955 -6.1205 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 2.5929 0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 5.1850 -5.2565 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 4.4271 -7.5403 0.0000 N 0 0 5.9271 -7.5455 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 3.9685 -6.1121 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 3.8911 -1.5017 0.0000 N 0 0 5.1872 -3.7556 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 3.8890 -3.0026 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 -3.8777 7.2076 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 3 2 0 6 11 1 0 7 1 1 0 8 9 1 0 9 2 2 0 10 8 2 0 11 19 1 0 12 15 2 0 13 16 1 0 14 6 2 0 15 4 1 0 16 11 2 0 17 7 1 0 18 10 1 0 19 21 1 0 20 17 2 0 21 18 1 0 22 20 1 0 23 24 2 0 24 17 1 0 25 23 1 0 26 22 1 0 12 3 1 0 5 10 1 0 25 22 2 0 13 14 1 0 M END > 39921 > J. Med. Chem. 40(24)-1997 3915-3925 > EGFR > 8.1427 $$$$ SciTegic07090714142D 26 29 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 6.3955 6.1205 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 2.5929 -0.7486 0.0000 N 0 0 5.1850 5.2565 0.0000 C 0 0 4.4271 7.5403 0.0000 N 0 0 5.9271 7.5455 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 3.9685 6.1121 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 3.8911 1.5017 0.0000 N 0 0 5.1872 3.7556 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 3.8890 3.0026 0.0000 C 0 0 -3.8777 7.2076 0.0000 Br 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 7 1 0 5 1 1 0 6 10 2 0 7 20 1 0 8 15 1 0 9 4 2 0 10 12 1 0 11 2 1 0 12 2 2 0 13 14 2 0 14 3 1 0 15 7 2 0 16 5 1 0 17 11 2 0 18 16 2 0 19 10 1 0 20 22 1 0 21 18 1 0 22 19 1 0 23 21 1 0 24 25 2 0 25 16 1 0 26 24 1 0 11 13 1 0 6 17 1 0 21 26 2 0 9 8 1 0 M END > 42405 > J. Med. Chem. 41(5)-1998 742-751 > EGFR > 8.2007 $$$$ SciTegic07090714142D 27 29 0 0 0 0 999 V2000 -1.3070 5.2502 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -2.6061 6.0003 0.0000 C 0 0 -0.0080 6.0003 0.0000 C 0 0 -1.3039 3.7494 0.0000 C 0 0 -0.0031 3.0008 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 3.6375 -0.9049 0.0000 O 0 0 2.5951 -3.0039 0.0000 N 0 0 -2.6061 7.5003 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -0.0080 7.5003 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 -3.6453 5.4003 0.0000 O 0 0 3.8933 -3.7570 0.0000 C 0 0 1.0312 8.1004 0.0000 O 0 0 5.1894 -6.0109 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 5.1895 -7.5109 0.0000 C 0 0 6.4885 -5.2610 0.0000 C 0 0 7.7876 -6.0110 0.0000 C 0 0 6.4885 -8.2610 0.0000 C 0 0 7.7875 -7.5110 0.0000 C 0 0 2 3 1 0 3 8 2 0 4 1 2 0 5 1 1 0 6 1 1 0 7 6 1 0 8 12 1 0 9 2 2 0 10 2 1 0 11 4 1 0 12 7 1 0 13 5 2 0 14 13 1 0 15 4 1 0 16 10 1 0 17 13 1 0 18 21 1 0 19 20 2 0 20 22 1 0 21 16 1 0 22 12 2 0 23 18 2 0 24 18 1 0 25 24 2 0 26 23 1 0 27 25 1 0 11 14 2 0 19 3 1 0 27 26 2 0 M END > 85152 > J. Med. Chem. 44(3)-2001 441-452 > EGFR > 3.3010 $$$$ SciTegic07090714142D 27 29 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 -5.2003 -1.4932 0.0000 C 0 0 2.5951 -3.0039 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -6.4994 -0.7433 0.0000 C 0 0 -5.2004 -2.9933 0.0000 C 0 0 -3.8990 -0.7455 0.0000 C 0 0 -2.6003 -1.4978 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -7.7985 -1.4932 0.0000 C 0 0 -6.4995 -3.7433 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -7.7985 -2.9932 0.0000 C 0 0 2.3383 1.3500 0.0000 O 0 0 -6.4994 0.4567 0.0000 O 0 0 3.8912 -5.2578 0.0000 C 0 0 -6.4995 -4.9433 0.0000 O 0 0 5.1876 -6.0124 0.0000 C 0 0 2.5895 -6.0034 0.0000 C 0 0 2.5844 -7.5034 0.0000 C 0 0 5.1824 -7.5124 0.0000 C 0 0 3.8808 -8.2579 0.0000 C 0 0 2 1 1 0 3 9 1 0 4 2 1 0 5 1 1 0 6 1 2 0 7 3 2 0 8 3 1 0 9 10 1 0 10 12 1 0 11 2 2 0 12 6 1 0 13 5 2 0 14 7 1 0 15 8 2 0 16 4 1 0 17 12 2 0 18 15 1 0 19 5 1 0 20 7 1 0 21 16 1 0 22 15 1 0 23 21 2 0 24 21 1 0 25 24 2 0 26 23 1 0 27 25 1 0 13 17 1 0 26 27 2 0 14 18 2 0 M END > 85140 > J. Med. Chem. 44(3)-2001 441-452 > EGFR > 5.0969 $$$$ SciTegic07090714142D 27 30 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -3.6187 1.4919 0.0000 N 0 0 -3.6187 -1.4919 0.0000 N 0 0 2.0825 2.3453 0.0000 O 0 0 2.0907 -2.3426 0.0000 O 0 0 -3.6267 2.9927 0.0000 C 0 0 -3.6267 -2.9927 0.0000 C 0 0 -3.6365 5.9928 0.0000 C 0 0 -3.6365 -5.9928 0.0000 C 0 0 -4.9282 3.7385 0.0000 C 0 0 -4.9282 -3.7385 0.0000 C 0 0 -2.3301 3.7470 0.0000 C 0 0 -2.3301 -3.7470 0.0000 C 0 0 -2.3350 -5.2470 0.0000 C 0 0 -2.3350 5.2470 0.0000 C 0 0 -4.9331 -5.2385 0.0000 C 0 0 -4.9331 5.2385 0.0000 C 0 0 -3.6404 -7.1928 0.0000 O 0 0 -3.6404 7.1928 0.0000 O 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 9 1 0 7 8 1 0 8 5 2 0 9 4 2 0 10 6 1 0 11 7 1 0 12 2 2 0 13 3 2 0 14 10 1 0 15 11 1 0 16 23 2 0 17 22 2 0 18 14 1 0 19 15 1 0 20 14 2 0 21 15 2 0 22 21 1 0 23 20 1 0 24 19 2 0 25 18 2 0 26 17 1 0 27 16 1 0 5 4 1 0 7 6 2 0 24 17 1 0 25 16 1 0 M END > 15906 > J. Med. Chem. 37(7)-1994 1015-1027 > EGFR > 5.6021 $$$$ SciTegic07090714142D 27 30 0 0 0 0 999 V2000 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -3.9086 1.5029 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 3.8942 -1.4964 0.0000 N 0 0 -3.6486 -1.3517 0.0000 O 0 0 -3.9097 3.0028 0.0000 C 0 0 -5.2071 0.7519 0.0000 C 0 0 7.7858 0.7649 0.0000 N 0 0 -1.2928 -2.6973 0.0000 C 0 0 5.1929 -0.7441 0.0000 C 0 0 -2.8709 3.6035 0.0000 Cl 0 0 -5.2063 -0.4481 0.0000 Cl 0 0 6.4946 -1.4896 0.0000 C 0 0 5.1877 0.7559 0.0000 C 0 0 6.4842 1.5104 0.0000 C 0 0 7.7910 -0.7351 0.0000 C 0 0 -6.5078 3.0010 0.0000 C 0 0 -5.2093 3.7519 0.0000 C 0 0 -6.5067 1.5010 0.0000 C 0 0 2 4 1 0 3 1 1 0 4 1 1 0 5 3 2 0 6 3 1 0 7 2 2 0 8 2 1 0 9 5 1 0 10 11 1 0 11 6 2 0 12 9 1 0 13 4 2 0 14 8 2 0 15 8 1 0 16 23 1 0 17 1 1 0 18 12 1 0 19 14 1 0 20 15 1 0 21 18 2 0 22 18 1 0 23 22 2 0 24 21 1 0 25 27 1 0 26 14 1 0 27 15 2 0 6 7 1 0 10 9 2 0 26 25 2 0 24 16 2 0 M END > 46078 > J. Med. Chem. 41(17)-1998 3276-3292 > EGFR > 6.0410 $$$$ SciTegic07090714142D 27 30 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 2.5929 -0.7486 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 5.1850 5.2565 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 5.1746 8.2565 0.0000 O 0 0 3.8911 1.5017 0.0000 N 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 3.8890 3.0026 0.0000 C 0 0 5.1872 3.7556 0.0000 C 0 0 6.4815 6.0111 0.0000 C 0 0 3.8834 6.0021 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 3.8782 7.5021 0.0000 C 0 0 6.4763 7.5110 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 -3.8777 7.2076 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 6 2 0 6 8 1 0 7 2 1 0 8 2 2 0 9 11 2 0 10 19 1 0 11 3 1 0 12 7 2 0 13 4 1 0 14 24 1 0 15 6 1 0 16 13 2 0 17 16 1 0 18 15 1 0 19 18 1 0 20 10 1 0 21 10 1 0 22 23 2 0 23 13 1 0 24 21 1 0 25 20 1 0 26 22 1 0 27 17 1 0 7 9 1 0 12 5 1 0 17 26 2 0 25 14 1 0 M END > 42417 > J. Med. Chem. 41(5)-1998 742-751 > EGFR > 7.6990 $$$$ SciTegic07090714142D 27 30 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 8.0883 -7.8023 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 2.5929 0.7486 0.0000 N 0 0 6.4832 -6.0096 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 6.6211 -7.4904 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 8.8383 -6.5032 0.0000 C 0 0 7.8346 -5.3885 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 3.8911 -1.5017 0.0000 N 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 5.1850 -5.2565 0.0000 C 0 0 5.1872 -3.7556 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 3.8890 -3.0026 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 -3.8777 7.2076 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 3 2 0 6 12 2 0 7 1 1 0 8 10 1 0 9 21 1 0 10 2 2 0 11 8 2 0 12 9 1 0 13 14 2 0 14 4 1 0 15 16 2 0 16 9 1 0 17 7 1 0 18 11 1 0 19 17 2 0 20 19 1 0 21 22 1 0 22 24 1 0 23 25 2 0 24 18 1 0 25 17 1 0 26 23 1 0 27 20 1 0 13 3 1 0 5 11 1 0 26 20 2 0 6 15 1 0 M END > 39920 > J. Med. Chem. 40(24)-1997 3915-3925 > EGFR > 8.4559 $$$$ SciTegic07090714142D 27 30 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 N 0 0 -11.4671 1.9822 0.0000 N 0 0 1.2995 2.9981 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -9.1121 1.4882 0.0000 N 0 0 -10.4636 0.8673 0.0000 C 0 0 1.2964 -1.4973 0.0000 N 0 0 2.5929 -0.7486 0.0000 C 0 0 -10.7170 3.2811 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -9.2498 2.9691 0.0000 C 0 0 2.6003 3.7467 0.0000 C 0 0 2.6056 5.2467 0.0000 C 0 0 -3.9122 1.4966 0.0000 N 0 0 3.9072 5.9922 0.0000 C 0 0 3.9114 7.1922 0.0000 Br 0 0 -7.8109 0.7403 0.0000 C 0 0 -6.5121 1.4924 0.0000 C 0 0 5.1985 3.7377 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 3.8969 2.9922 0.0000 C 0 0 5.2037 5.2377 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 2 2 0 6 11 2 0 7 2 1 0 8 1 1 0 9 15 1 0 10 22 1 0 11 10 1 0 12 8 1 0 13 12 2 0 14 16 2 0 15 8 2 0 16 10 1 0 17 7 1 0 18 17 2 0 19 4 1 0 20 18 1 0 21 20 1 0 22 23 1 0 23 25 1 0 24 26 2 0 25 19 1 0 26 17 1 0 27 24 1 0 9 4 2 0 13 5 1 0 27 20 2 0 14 6 1 0 M END > 37329 > J. Med. Chem. 40(12)-1997 1820-1826 > EGFR > 8.6383 $$$$ SciTegic07090714142D 28 31 0 0 0 0 999 V2000 3.6500 2.9355 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 4.2319 4.2772 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 4.7446 1.9258 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 5.7185 4.1348 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 6.0370 2.6741 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 3.4623 5.5629 0.0000 C 0 0 1.1906 6.8276 0.0000 C 0 0 3.7889 0.0269 0.0000 O 0 0 -1.0028 -1.5132 0.0000 C 0 0 -4.6560 0.8780 0.0000 O 0 0 -2.3155 -0.7475 0.0000 C 0 0 -0.0092 6.8093 0.0000 O 0 0 1.9616 5.5400 0.0000 C 0 0 -3.6319 2.6865 0.0000 O 0 0 1.7743 7.8761 0.0000 O 0 0 6.8201 5.1587 0.0000 C 0 0 7.4648 2.2016 0.0000 C 0 0 8.2658 4.6901 0.0000 C 0 0 8.5843 3.2294 0.0000 C 0 0 2 5 2 0 3 2 1 0 4 1 2 0 5 1 1 0 6 1 1 0 7 2 1 0 8 4 1 0 9 3 1 0 10 6 1 0 11 7 1 0 12 7 2 0 13 12 1 0 14 13 1 0 15 4 1 0 16 22 1 0 17 3 2 0 18 11 2 0 19 14 2 0 20 13 2 0 21 16 2 0 22 15 1 0 23 14 1 0 24 16 1 0 25 8 1 0 26 10 1 0 27 25 1 0 28 26 1 0 10 8 2 0 27 28 1 0 9 11 1 0 20 18 1 0 M END > 59354 > J. Med. Chem. 43(14)-2000 2655-2663 > EGFR > 4.2480 $$$$ SciTegic07090714142D 28 30 0 0 0 0 999 V2000 2.5951 -3.0039 0.0000 N 0 0 2.5973 -1.5031 0.0000 C 0 0 3.8056 -3.8679 0.0000 C 0 0 3.3372 -5.2929 0.0000 N 0 0 1.8372 -5.2877 0.0000 C 0 0 1.3786 -3.8595 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 3.3932 -11.9827 0.0000 S 0 0 1.2990 0.7500 0.0000 C 0 0 2.7828 -10.6116 0.0000 C 0 0 0.9548 -6.4986 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 4.5865 -12.1089 0.0000 O 0 0 2.6875 -12.9533 0.0000 O 0 0 3.6375 -0.9049 0.0000 O 0 0 3.8808 -13.0792 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 4.9460 -3.4943 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 1.2910 -10.4548 0.0000 C 0 0 3.6644 -9.3981 0.0000 C 0 0 2.3383 1.3500 0.0000 F 0 0 1.5625 -7.8709 0.0000 C 0 0 0.0000 -2.7000 0.0000 F 0 0 0.6809 -9.0845 0.0000 C 0 0 3.0543 -8.0278 0.0000 C 0 0 0.0000 2.7000 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 6 2 0 6 1 1 0 7 2 1 0 8 10 1 0 9 7 1 0 10 22 1 0 11 5 1 0 12 7 2 0 13 8 2 0 14 8 2 0 15 2 2 0 16 8 1 0 17 9 2 0 18 3 1 0 19 12 1 0 20 19 2 0 21 26 1 0 22 27 2 0 23 9 1 0 24 11 1 0 25 12 1 0 26 24 2 0 27 24 1 0 28 17 1 0 5 4 1 0 20 17 1 0 21 10 2 0 M END > 152667 > J. Med. Chem. 48(13)-2005 4208-4211 > EGFR > 4.3391 $$$$ SciTegic07090714142D 28 30 0 0 0 0 999 V2000 -3.8933 3.7570 0.0000 C 0 0 2.5973 -1.5031 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -3.8934 5.2570 0.0000 C 0 0 -5.1925 3.0070 0.0000 C 0 0 -2.5951 3.0039 0.0000 C 0 0 -2.5973 1.5031 0.0000 N 0 0 3.6375 -0.9049 0.0000 O 0 0 2.5951 -3.0039 0.0000 N 0 0 0.0000 -1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -5.1924 6.0070 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -6.4915 3.7571 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -6.4915 5.2571 0.0000 C 0 0 -2.8542 5.8570 0.0000 O 0 0 -7.5307 3.1571 0.0000 O 0 0 5.1873 -7.5117 0.0000 C 0 0 3.8933 -3.7570 0.0000 C 0 0 5.1894 -6.0109 0.0000 C 0 0 6.4837 -8.2663 0.0000 C 0 0 3.8856 -8.2573 0.0000 C 0 0 3.8912 -5.2578 0.0000 C 0 0 3.8804 -9.7573 0.0000 C 0 0 6.4785 -9.7663 0.0000 C 0 0 5.1769 -10.5118 0.0000 C 0 0 2 3 1 0 3 11 1 0 4 1 2 0 5 1 1 0 6 1 1 0 7 6 1 0 8 2 2 0 9 2 1 0 10 15 1 0 11 16 2 0 12 4 1 0 13 7 1 0 14 5 2 0 15 13 2 0 16 13 1 0 17 14 1 0 18 4 1 0 19 14 1 0 20 22 1 0 21 9 1 0 22 25 1 0 23 20 2 0 24 20 1 0 25 21 1 0 26 24 2 0 27 23 1 0 28 26 1 0 12 17 2 0 3 10 2 0 28 27 2 0 M END > 85151 > J. Med. Chem. 44(3)-2001 441-452 > EGFR > 4.4815 $$$$ SciTegic07090714142D 28 31 0 0 1 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 O 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 1.2964 2.9980 0.0000 C 0 0 2 0 0 0 2.5929 -0.7486 0.0000 C 0 0 -3.9086 1.5029 0.0000 C 0 0 2.5942 3.7503 0.0000 C 0 0 1 0 0 0 1.2915 5.9981 0.0000 N 0 0 -0.0038 3.7460 0.0000 C 0 0 2.5918 5.2503 0.0000 C 0 0 -1.2928 -2.6973 0.0000 O 0 0 -5.2125 0.7617 0.0000 C 0 0 -0.0063 5.2460 0.0000 C 0 0 1.2964 -2.6973 0.0000 O 0 0 3.6321 1.3486 0.0000 O 0 0 3.6345 3.1520 0.0000 O 0 0 -5.2206 -0.4383 0.0000 Cl 0 0 -3.8985 3.0029 0.0000 C 0 0 1.2895 7.1981 0.0000 C 0 0 -6.5065 1.5203 0.0000 C 0 0 -5.1925 3.7616 0.0000 C 0 0 -6.4965 3.0203 0.0000 C 0 0 2 1 1 0 3 4 1 0 4 1 1 0 5 1 2 0 6 2 1 0 7 3 2 0 8 2 2 0 9 5 1 0 10 5 1 1 11 9 2 0 12 3 1 0 13 10 1 0 14 19 1 0 15 10 1 0 16 13 1 0 17 6 2 0 18 12 2 0 19 15 1 0 20 8 1 0 21 9 1 0 13 22 1 1 23 18 1 0 24 12 1 0 25 14 1 0 26 18 1 0 27 24 2 0 28 27 1 0 11 8 1 0 7 6 1 0 14 16 1 0 28 26 2 0 M END > 74323 > J. Med. Chem. 43(22)-2000 4126-4134 > EGFR > 4.6576 $$$$ SciTegic07090714142D 28 31 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -2.6111 0.7486 0.0000 N 0 0 5.1929 0.7441 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 3.8942 1.4964 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 10.3932 0.7374 0.0000 N 0 0 -2.5870 3.7544 0.0000 C 0 0 6.4942 1.4919 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 9.0941 1.4873 0.0000 C 0 0 7.7928 0.7396 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -0.2489 3.5938 0.0000 C 0 0 11.6923 1.4873 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 9.0942 2.9874 0.0000 C 0 0 11.6923 2.9873 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 10.3933 3.7374 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 1 2 0 5 9 2 0 6 2 1 0 7 2 2 0 8 10 2 0 9 14 1 0 10 4 1 0 11 16 1 0 12 3 1 0 13 5 1 0 14 7 1 0 15 6 2 0 16 17 1 0 17 13 1 0 18 14 2 0 19 3 1 0 20 11 2 0 21 12 1 0 22 12 2 0 23 16 2 0 24 27 2 0 25 22 1 0 26 21 2 0 27 23 1 0 28 25 2 0 8 6 1 0 18 15 1 0 28 26 1 0 24 20 1 0 M END > 113883 > J. Med. Chem. 46(20)-2003 4313-4321 > EGFR > 5.0315 $$$$ SciTegic07090714142D 28 30 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 -0.0020 3.0008 0.0000 N 0 0 -2.6020 2.9972 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 2.6003 -1.4977 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 -1.3030 3.7490 0.0000 C 0 0 2.5979 3.0043 0.0000 C 0 0 1.2969 3.7525 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -3.9034 3.7432 0.0000 C 0 0 -2.5975 1.4972 0.0000 C 0 0 3.8973 3.7538 0.0000 C 0 0 3.6387 -0.8963 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -5.2002 2.9892 0.0000 C 0 0 -3.8942 0.7432 0.0000 C 0 0 2.6024 -2.6977 0.0000 O 0 0 -5.1955 1.4892 0.0000 C 0 0 0.0000 -2.7000 0.0000 O 0 0 -3.9072 4.9432 0.0000 O 0 0 3.8978 4.9538 0.0000 O 0 0 -3.8905 -0.4568 0.0000 O 0 0 2.5975 1.5042 0.0000 C 0 0 5.1961 3.0033 0.0000 C 0 0 3.8962 0.7537 0.0000 C 0 0 5.1955 1.5033 0.0000 C 0 0 2 6 1 0 3 7 1 0 4 1 2 0 5 1 1 0 6 4 1 0 7 2 1 0 8 9 1 0 9 2 1 0 10 1 1 0 11 3 2 0 12 3 1 0 13 8 2 0 14 5 2 0 15 16 1 0 16 10 2 0 17 11 1 0 18 12 2 0 19 5 1 0 20 18 1 0 21 10 1 0 22 11 1 0 23 13 1 0 24 18 1 0 25 8 1 0 26 13 1 0 27 25 2 0 28 27 1 0 15 6 2 0 28 26 2 0 20 17 2 0 M END > 72233 > J. Med. Chem. 36(20)-1993 3010-3014 > EGFR > 5.1549 $$$$ SciTegic07090714142D 28 30 0 0 0 0 999 V2000 -9.1147 5.9921 0.0000 C 0 0 -6.5121 1.4924 0.0000 C 0 0 -7.8140 5.2434 0.0000 C 0 0 -9.1193 7.4929 0.0000 C 0 0 -10.4139 5.2408 0.0000 C 0 0 -7.8113 0.7426 0.0000 C 0 0 -9.1103 1.4927 0.0000 C 0 0 -7.8110 3.7426 0.0000 C 0 0 -11.4527 4.6401 0.0000 N 0 0 -6.5121 2.9924 0.0000 C 0 0 -9.1101 2.9927 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -10.1600 8.0904 0.0000 O 0 0 -3.9122 1.4966 0.0000 S 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -8.0817 8.0958 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -7.8115 -0.4574 0.0000 O 0 0 -10.4117 0.7451 0.0000 O 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -11.4500 1.3467 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 10 2 0 3 1 2 0 4 1 1 0 5 1 1 0 6 7 2 0 7 11 1 0 8 3 1 0 9 5 3 0 10 8 1 0 11 8 2 0 12 2 1 0 13 16 2 0 14 4 2 0 15 12 1 0 16 18 1 0 17 20 2 0 18 15 1 0 19 4 1 0 20 23 1 0 21 6 1 0 22 7 1 0 23 18 2 0 24 13 1 0 25 17 1 0 26 22 1 0 27 24 2 0 28 25 2 0 2 6 1 0 17 13 1 0 28 27 1 0 M END > 73103 > J. Med. Chem. 36(23)-1993 3556-3564 > EGFR > 5.1805 $$$$ SciTegic07090714142D 28 31 0 0 0 0 999 V2000 6.3513 -1.2462 0.0000 C 0 0 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 C 0 0 7.2076 -2.4317 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 7.2036 -0.0251 0.0000 N 0 0 8.6290 -1.9735 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 6.7319 -3.8527 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 8.6265 -0.4785 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 4.0872 0.0320 0.0000 S 0 0 4.8506 -1.2602 0.0000 S 0 0 1.3808 3.5211 0.0000 O 0 0 7.5270 -4.7514 0.0000 O 0 0 5.2613 -4.1524 0.0000 N 0 0 3.6500 2.9355 0.0000 N 0 0 9.9247 -2.7371 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 9.9197 0.2894 0.0000 C 0 0 4.0244 4.0756 0.0000 C 0 0 4.8802 -5.2902 0.0000 C 0 0 11.2361 -1.9692 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 11.2336 -0.4742 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 2 13 1 0 3 2 2 0 4 1 2 0 5 2 1 0 6 1 1 0 7 4 1 0 8 3 1 0 9 4 1 0 10 3 1 0 11 6 1 0 12 5 1 0 13 14 1 0 14 1 1 0 15 10 2 0 16 9 2 0 17 9 1 0 18 10 1 0 19 7 1 0 20 8 2 0 21 12 2 0 22 11 1 0 23 18 1 0 24 17 1 0 25 19 2 0 26 20 1 0 27 22 2 0 28 21 1 0 11 7 2 0 27 25 1 0 8 12 1 0 26 28 2 0 M END > 20877 > J. Med. Chem. 38(1)-1995 58-67 > EGFR > 5.2147 $$$$ SciTegic07090714142D 29 31 0 0 0 0 999 V2000 -1.3070 5.2502 0.0000 C 0 0 1.2990 -0.7500 0.0000 C 0 0 -1.3039 3.7494 0.0000 C 0 0 -0.0031 3.0008 0.0000 N 0 0 3.8990 -0.7455 0.0000 C 0 0 2.6003 -1.4977 0.0000 C 0 0 -2.6061 6.0003 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -0.0080 6.0003 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 3.8969 0.4545 0.0000 O 0 0 0.0000 1.5000 0.0000 C 0 0 5.2003 -1.4932 0.0000 N 0 0 -2.6061 7.5003 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -0.0080 7.5003 0.0000 C 0 0 6.4990 -0.7409 0.0000 O 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 -3.6453 5.4003 0.0000 O 0 0 0.0000 -2.7000 0.0000 O 0 0 1.0312 8.1004 0.0000 O 0 0 9.0990 -0.7364 0.0000 C 0 0 7.8003 -1.4887 0.0000 C 0 0 10.4007 -1.4818 0.0000 C 0 0 9.0939 0.7636 0.0000 C 0 0 10.3903 1.5181 0.0000 C 0 0 11.6971 -0.7274 0.0000 C 0 0 11.6919 0.7726 0.0000 C 0 0 2 10 1 0 3 1 1 0 4 3 2 0 5 6 1 0 6 2 1 0 7 1 2 0 8 15 1 0 9 1 1 0 10 12 2 0 11 5 2 0 12 4 1 0 13 5 1 0 14 7 1 0 15 18 2 0 16 9 2 0 17 13 1 0 18 12 1 0 19 16 1 0 20 7 1 0 21 8 1 0 22 16 1 0 23 24 1 0 24 17 1 0 25 23 2 0 26 23 1 0 27 26 2 0 28 25 1 0 29 27 1 0 14 19 2 0 2 8 2 0 28 29 2 0 M END > 15810 > J. Med. Chem. 37(6)-1994 845-859 > EGFR > 4.3010 $$$$ SciTegic07090714142D 29 32 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 2.5929 0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 6.4832 -6.0096 0.0000 N 0 0 9.0814 -7.5096 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 3.8911 -1.5017 0.0000 N 0 0 7.7823 -8.2596 0.0000 C 0 0 9.0814 -6.0096 0.0000 C 0 0 6.4833 -7.5096 0.0000 C 0 0 7.7824 -5.2596 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 5.1850 -5.2565 0.0000 C 0 0 5.1872 -3.7556 0.0000 C 0 0 10.1206 -8.1097 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 3.8890 -3.0026 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 -3.8777 7.2076 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 3 2 0 6 1 1 0 7 8 1 0 8 2 2 0 9 7 2 0 10 22 1 0 11 17 1 0 12 13 2 0 13 4 1 0 14 6 1 0 15 9 1 0 16 18 1 0 17 19 1 0 18 10 1 0 19 10 1 0 20 14 2 0 21 20 1 0 22 23 1 0 23 26 1 0 24 11 1 0 25 27 2 0 26 15 1 0 27 14 1 0 28 25 1 0 29 21 1 0 12 3 1 0 9 5 1 0 28 21 2 0 11 16 1 0 M END > 39919 > J. Med. Chem. 40(24)-1997 3915-3925 > EGFR > 8.2518 $$$$ SciTegic07090714142D 30 33 0 0 0 0 999 V2000 -6.5121 1.4924 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 -3.9122 1.4966 0.0000 N 0 0 -9.1176 7.4929 0.0000 C 0 0 -7.8113 0.7426 0.0000 C 0 0 -6.5121 2.9924 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -10.4166 8.2431 0.0000 C 0 0 -5.2090 -0.4555 0.0000 O 0 0 -7.8185 8.2429 0.0000 C 0 0 -9.1147 5.9921 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -7.8139 5.2434 0.0000 N 0 0 -7.8110 3.7426 0.0000 C 0 0 -9.1103 1.4927 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -10.4164 9.7431 0.0000 C 0 0 -7.8184 9.7429 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -9.1101 2.9927 0.0000 C 0 0 -9.1173 10.4930 0.0000 C 0 0 -7.8115 -0.4574 0.0000 O 0 0 -11.4559 7.6432 0.0000 O 0 0 -6.7791 10.3428 0.0000 O 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 11 1 0 5 1 1 0 6 1 2 0 7 13 1 0 8 4 2 0 9 2 2 0 10 4 1 0 11 15 1 0 12 3 1 0 13 12 1 0 14 18 1 0 15 16 1 0 16 6 1 0 17 5 2 0 18 21 1 0 19 8 1 0 20 10 2 0 21 12 1 0 22 16 2 0 23 20 1 0 24 5 1 0 25 8 1 0 26 20 1 0 27 7 1 0 28 14 1 0 29 27 2 0 30 28 2 0 17 22 1 0 7 14 2 0 19 23 2 0 30 29 1 0 M END > 85147 > J. Med. Chem. 44(3)-2001 441-452 > EGFR > 5.3979 $$$$ SciTegic07090714142D 31 33 0 0 0 0 999 V2000 -2.6047 1.4864 0.0000 C 0 0 -2.7022 0.0262 0.0000 C 0 0 -3.9217 2.1246 0.0000 O 0 0 -4.9223 1.0070 0.0000 C 0 0 -4.1686 -0.2899 0.0000 C 0 0 -2.6092 2.9872 0.0000 C 0 0 -1.5667 -0.9550 0.0000 C 0 0 -1.3026 0.7393 0.0000 C 0 0 2.5937 1.5031 0.0000 C 0 0 3.8990 -0.7455 0.0000 C 0 0 -6.1160 1.1290 0.0000 O 0 0 2.5875 3.0031 0.0000 C 0 0 1.2977 0.7477 0.0000 C 0 0 -0.0044 1.4924 0.0000 C 0 0 3.8950 0.7553 0.0000 C 0 0 -1.5716 3.5900 0.0000 O 0 0 5.2003 -1.4932 0.0000 C 0 0 -4.6535 -1.3875 0.0000 O 0 0 -0.1180 -0.5889 0.0000 C 0 0 -1.9822 -2.3984 0.0000 C 0 0 1.2854 3.7477 0.0000 C 0 0 -3.9108 3.7345 0.0000 O 0 0 -0.0106 2.9924 0.0000 C 0 0 0.5170 -3.1081 0.0000 C 0 0 0.9268 -1.6652 0.0000 C 0 0 -0.9375 -3.4748 0.0000 C 0 0 3.6242 3.6073 0.0000 O 0 0 1.3528 -3.9692 0.0000 O 0 0 6.2387 -0.8917 0.0000 C 0 0 5.2024 -2.6932 0.0000 C 0 0 -3.9144 4.9345 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 1 0 5 2 2 0 6 1 1 0 7 2 1 0 8 1 1 0 9 13 2 0 10 15 1 0 11 4 2 0 12 21 2 0 13 14 1 0 14 8 1 0 15 9 1 0 16 6 2 0 17 10 2 0 18 5 1 0 19 7 2 0 20 7 1 0 21 23 1 0 22 6 1 0 23 14 2 0 24 26 1 0 25 19 1 0 26 20 2 0 27 12 1 0 28 24 1 0 29 17 1 0 30 17 1 0 31 22 1 0 4 5 1 0 24 25 2 0 12 9 1 0 M END > 74334 > J. Med. Chem. 43(22)-2000 4126-4134 > EGFR > 3.2291 $$$$ SciTegic07090714142D 31 34 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 5.1850 -5.2565 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 5.1746 -8.2565 0.0000 N 0 0 -3.8807 6.0076 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 6.4763 -7.5110 0.0000 C 0 0 3.8782 -7.5021 0.0000 C 0 0 6.4815 -6.0111 0.0000 C 0 0 3.8834 -6.0021 0.0000 C 0 0 -1.5428 5.8519 0.0000 F 0 0 3.8911 -1.5017 0.0000 O 0 0 -5.1852 3.7608 0.0000 C 0 0 3.8911 1.5017 0.0000 O 0 0 -6.2193 5.8633 0.0000 Cl 0 0 5.1872 -3.7556 0.0000 C 0 0 3.8890 -3.0026 0.0000 C 0 0 5.1705 -9.4565 0.0000 C 0 0 3.8894 2.7017 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 1 2 0 6 2 2 0 7 3 2 0 8 4 1 0 9 5 1 0 10 9 2 0 11 8 1 0 12 28 1 0 13 3 1 0 14 20 1 0 15 11 2 0 16 13 2 0 17 8 2 0 18 25 2 0 19 21 1 0 20 22 1 0 21 12 1 0 22 12 1 0 23 11 1 0 24 10 1 0 25 17 1 0 26 9 1 0 27 18 1 0 28 29 1 0 29 24 1 0 30 14 1 0 31 26 1 0 10 7 1 0 6 16 1 0 18 15 1 0 14 19 1 0 M END > 92902 > J. Med. Chem. 45(6)-2002 1300-1312 > EGFR > 6.6990 $$$$ SciTegic07090714142D 31 34 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 6.4942 1.4919 0.0000 C 0 0 7.7955 2.2396 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 3.8942 1.4964 0.0000 N 0 0 5.1929 0.7441 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 -2.5835 5.2544 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 10.3954 2.2351 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 5.1908 -0.4559 0.0000 O 0 0 12.9884 0.7260 0.0000 O 0 0 -5.1852 3.7608 0.0000 C 0 0 9.0967 2.9873 0.0000 C 0 0 -3.8777 7.2076 0.0000 Cl 0 0 -3.8880 3.0076 0.0000 C 0 0 -6.2193 5.8633 0.0000 F 0 0 11.6971 2.9805 0.0000 C 0 0 10.3903 0.7350 0.0000 C 0 0 11.6867 -0.0195 0.0000 C 0 0 12.9936 2.2260 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 11 1 0 5 9 1 0 6 5 3 0 7 1 1 0 8 4 1 0 9 8 1 0 10 20 1 0 11 2 2 0 12 13 1 0 13 18 2 0 14 2 1 0 15 24 1 0 16 17 2 0 17 3 1 0 18 7 1 0 19 23 1 0 20 14 2 0 21 9 2 0 22 30 1 0 23 26 2 0 24 6 1 0 25 12 1 0 26 18 1 0 27 19 1 0 28 15 1 0 29 15 1 0 30 29 1 0 31 28 1 0 16 14 1 0 10 4 2 0 19 12 2 0 22 31 1 0 M END > 167836 > J. Med. Chem. 49(4)-2006 1475-1485 > EGFR > 7.8539 $$$$ SciTegic07090714142D 31 34 0 0 0 0 999 V2000 1.7138 1.2033 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 4.7388 1.9224 0.0000 N 0 0 4.2449 4.2986 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 6.0412 2.6666 0.0000 C 0 0 5.7359 4.1352 0.0000 C 0 0 -0.9971 3.0138 0.0000 N 0 0 -3.5873 6.0231 0.0000 C 0 0 -2.2900 5.2700 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 3.7889 0.0269 0.0000 O 0 0 9.9949 2.3187 0.0000 C 0 0 -4.8881 5.2761 0.0000 C 0 0 10.9679 3.0210 0.0000 O 0 0 -4.8917 3.7761 0.0000 C 0 0 7.4085 2.0539 0.0000 C 0 0 -3.5845 7.2231 0.0000 Cl 0 0 8.6253 2.9324 0.0000 C 0 0 -3.5944 3.0231 0.0000 C 0 0 -5.9259 5.8786 0.0000 F 0 0 10.1171 1.1249 0.0000 O 0 0 3.6433 5.3370 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 5 1 0 5 1 1 0 6 2 2 0 7 1 2 0 8 7 1 0 9 8 1 0 10 8 2 0 11 3 2 0 12 6 1 0 13 9 1 0 14 10 1 0 15 6 1 0 16 17 2 0 17 19 1 0 18 12 2 0 19 15 1 0 20 5 2 0 21 27 1 0 22 24 2 0 23 21 2 0 24 28 1 0 25 13 1 0 26 16 1 0 27 25 1 0 28 19 2 0 29 22 1 0 30 21 1 0 31 10 1 0 4 3 1 0 14 13 2 0 18 11 1 0 22 16 1 0 M END > 4846 > Bioorg. Med. Chem. Lett. 12(16)-2002 2153-2157 > EGFR > 8.3279 $$$$