SciTegic07090714172D 16 17 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 2.5988 -1.5004 0.0000 C 0 0 3.6380 -2.1004 0.0000 N 0 0 0.0000 -2.7000 0.0000 O 0 0 0.0000 3.0008 0.0000 C 0 0 -0.0048 6.0009 0.0000 N 0 0 -2.3383 1.3500 0.0000 C 0 0 1.2954 5.2529 0.0000 C 0 0 -1.3026 5.2488 0.0000 C 0 0 1.2978 3.7529 0.0000 C 0 0 -1.3002 3.7488 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 1 1 0 5 4 1 0 6 5 1 0 7 1 1 0 8 7 3 0 9 4 2 0 10 3 1 0 11 14 1 0 12 6 1 0 13 15 1 0 14 16 2 0 15 10 2 0 16 10 1 0 3 6 2 0 11 13 2 0 M END > 25444 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 3.9586 $$$$ SciTegic07090714172D 16 18 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 4.9397 -1.2009 0.0000 C 0 0 4.4262 -2.2855 0.0000 O 0 0 4.7275 1.3885 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 7.0761 0.2776 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 3 1 0 7 5 2 0 8 4 1 0 9 8 1 0 10 4 2 0 11 6 2 0 12 7 1 0 13 8 2 0 14 11 1 0 15 10 1 0 16 15 2 0 6 5 1 0 16 13 1 0 14 12 2 0 M END > 69247 > J. Med. Chem. 36(10)-1993 1387-1392 > PDE5 > 4.4318 $$$$ SciTegic07090714172D 17 18 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 1.2964 -2.6973 0.0000 N 0 0 -3.9091 1.5019 0.0000 O 0 0 -3.9091 -1.5019 0.0000 O 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 7 2 0 5 1 2 0 6 1 1 0 7 5 1 0 8 6 2 0 9 3 1 0 10 8 1 0 11 2 1 0 12 6 1 0 13 4 1 0 14 7 1 0 15 11 1 0 16 13 1 0 17 14 1 0 10 9 2 0 2 4 1 0 M END > 73410 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 5.0177 $$$$ SciTegic07090714172D 18 21 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -0.4800 0.5900 0.0000 C 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 0.9700 1.0600 0.0000 C 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 -1.8061 2.5600 0.0000 O 0 0 -4.1977 1.1927 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 1.3385 2.2020 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 2 0 6 5 1 0 7 2 2 0 8 3 1 0 9 8 1 0 10 1 1 0 11 5 1 0 12 10 1 0 13 6 2 0 14 4 1 0 10 15 1 1 12 16 1 1 17 11 1 0 18 15 1 0 7 12 1 0 16 18 1 0 9 11 2 0 4 6 1 0 M END > 40872 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 5.5376 $$$$ SciTegic07090714172D 18 20 0 0 0 0 999 V2000 0.0000 -1.3190 0.0000 N 0 0 -1.2274 0.8244 0.0000 C 0 0 -1.2274 -0.6045 0.0000 C 0 0 1.2274 0.8244 0.0000 C 0 0 1.2274 -0.6045 0.0000 C 0 0 -2.4915 1.5389 0.0000 C 0 0 -3.7006 0.8244 0.0000 C 0 0 -3.7006 -0.6045 0.0000 N 0 0 -4.9998 1.5775 0.0000 C 0 0 -2.4915 -1.3190 0.0000 C 0 0 -6.0400 0.9791 0.0000 O 0 0 -4.9980 3.0784 0.0000 O 0 0 2.4732 1.5389 0.0000 C 0 0 2.4732 -1.3190 0.0000 C 0 0 -6.2964 3.8312 0.0000 C 0 0 3.7372 0.8244 0.0000 C 0 0 3.7372 -0.6045 0.0000 C 0 0 -6.2950 5.0312 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 1 0 5 1 1 0 6 2 1 0 7 8 1 0 8 10 2 0 9 7 1 0 10 3 1 0 11 9 2 0 12 9 1 0 13 4 2 0 14 5 2 0 15 12 1 0 16 17 2 0 17 14 1 0 18 15 1 0 4 2 1 0 16 13 1 0 6 7 2 0 M END > 114259 > J. Med. Chem. 46(21)-2003 4525-4532 > PDE5 > 6.0969 $$$$ SciTegic07090714172D 19 20 0 0 0 0 999 V2000 -1.0028 1.5132 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 N 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -0.9971 3.0138 0.0000 C 0 0 -3.3560 1.3452 0.0000 O 0 0 -0.9991 -2.7132 0.0000 O 0 0 -3.3560 -1.3452 0.0000 C 0 0 4.0872 0.0320 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 4.8506 -1.2602 0.0000 O 0 0 6.0505 -1.2490 0.0000 C 0 0 -2.2889 4.9699 0.0000 C 0 0 -3.3352 3.1743 0.0000 C 0 0 2 1 1 0 3 2 2 0 4 1 1 0 5 4 1 0 6 5 1 0 7 3 1 0 8 2 1 0 9 8 1 0 10 1 1 0 11 4 2 0 12 6 2 0 13 5 1 0 14 9 1 0 15 10 1 0 16 14 1 0 17 16 1 0 18 15 1 0 19 15 1 0 6 3 1 0 7 9 2 0 M END > 37988 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 5.0000 $$$$ SciTegic07090714172D 19 21 0 0 0 0 999 V2000 1.7138 -1.2033 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 2.1855 -2.6254 0.0000 C 0 0 -2.3155 0.7475 0.0000 N 0 0 3.6552 -2.9294 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 4.1295 -4.3524 0.0000 C 0 0 -0.9971 3.0138 0.0000 N 0 0 3.3333 -5.2502 0.0000 F 0 0 4.6506 -1.8071 0.0000 C 0 0 5.5991 -4.6533 0.0000 C 0 0 -2.0337 3.6184 0.0000 C 0 0 6.1201 -2.1080 0.0000 C 0 0 6.5944 -3.5310 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 5 2 0 5 1 1 0 6 2 1 0 7 3 1 0 8 1 1 0 9 11 1 0 10 8 1 0 11 7 2 0 12 10 1 0 13 6 1 0 14 12 1 0 15 10 2 0 16 12 2 0 17 13 1 0 18 15 1 0 19 18 2 0 4 2 1 0 6 9 2 0 16 19 1 0 M END > 37204 > J. Med. Chem. 40(12)-1997 1768-1770 > PDE5 > 5.1871 $$$$ SciTegic07090714172D 19 21 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -3.6486 -1.3517 0.0000 Cl 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.8758 6.0130 0.0000 C 0 0 -1.2777 5.9976 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2688 7.4976 0.0000 C 0 0 -3.8669 7.5130 0.0000 C 0 0 -2.5634 8.2553 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 3 2 0 6 5 1 0 7 2 1 0 8 3 1 0 9 7 1 0 10 4 1 0 11 9 1 0 12 6 1 0 13 11 2 0 14 11 1 0 15 10 2 0 16 12 2 0 17 14 2 0 18 13 1 0 19 17 1 0 4 6 2 0 15 16 1 0 18 19 2 0 M END > 25414 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.3372 $$$$ SciTegic07090714172D 20 23 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -0.9971 -3.0138 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 -3.3560 -1.3452 0.0000 O 0 0 -4.9153 0.7255 0.0000 C 0 0 -2.2935 -3.7700 0.0000 C 0 0 -0.9991 2.7132 0.0000 O 0 0 -6.3365 0.7566 0.0000 C 0 0 -2.9615 -5.0248 0.0000 C 0 0 -3.7145 -3.7275 0.0000 C 0 0 -5.5732 -0.5347 0.0000 C 0 0 3.7889 0.0269 0.0000 N 0 0 2 1 1 0 3 6 1 0 4 1 2 0 5 2 1 0 6 4 1 0 7 1 1 0 8 4 1 0 9 7 2 0 10 2 1 0 11 3 1 0 12 5 2 0 13 11 1 0 14 10 1 0 15 6 2 0 16 13 1 0 17 14 1 0 18 14 1 0 19 13 1 0 20 9 1 0 9 8 1 0 5 3 1 0 18 17 1 0 16 19 1 0 M END > 15205 > J. Med. Chem. 37(4)-1994 476-485 > PDE5A > 4.1487 $$$$ SciTegic07090714172D 20 22 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 N 0 0 -1.0028 -1.5132 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 -3.6168 1.4950 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -4.9144 0.7421 0.0000 C 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -6.2151 1.4892 0.0000 C 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2133 -3.0109 0.0000 C 0 0 -4.9211 3.7421 0.0000 C 0 0 -7.2521 -3.6117 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 1 2 0 5 6 1 0 6 4 1 0 7 8 1 0 8 1 1 0 9 4 1 0 10 2 1 0 11 6 2 0 12 10 2 0 13 10 1 0 14 12 1 0 15 12 1 0 16 14 1 0 17 16 1 0 18 13 2 0 19 17 1 0 20 18 1 0 7 9 2 0 5 2 1 0 15 20 2 0 M END > 30228 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 5.0458 $$$$ SciTegic07090714172D 20 23 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 4.9397 -1.2009 0.0000 C 0 0 4.5128 -5.1493 0.0000 C 0 0 4.6726 -6.5619 0.0000 C 0 0 3.3175 -5.9188 0.0000 C 0 0 4.2991 -2.5581 0.0000 O 0 0 5.1534 -3.7921 0.0000 C 0 0 4.7275 1.3885 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 7.0761 0.2776 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 3 1 0 7 5 2 0 8 4 1 0 9 13 1 0 10 9 1 0 11 9 1 0 12 8 1 0 13 12 1 0 14 4 2 0 15 6 2 0 16 7 1 0 17 8 2 0 18 15 1 0 19 14 1 0 20 19 2 0 6 5 1 0 20 17 1 0 18 16 2 0 10 11 1 0 M END > 69246 > J. Med. Chem. 36(10)-1993 1387-1392 > PDE5 > 5.2218 $$$$ SciTegic07090714172D 21 24 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 4.9397 -1.2009 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 4.2991 -2.5581 0.0000 O 0 0 4.7275 1.3885 0.0000 C 0 0 5.1534 -3.7921 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 4.6480 -5.1908 0.0000 C 0 0 6.6406 -3.8051 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 7.0761 0.2776 0.0000 C 0 0 5.8431 -6.0974 0.0000 C 0 0 7.0746 -5.2410 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 3 1 0 7 4 1 0 8 5 2 0 9 7 1 0 10 4 2 0 11 9 1 0 12 7 2 0 13 6 2 0 14 8 1 0 15 11 1 0 16 11 1 0 17 13 1 0 18 10 1 0 19 18 2 0 20 15 1 0 21 16 1 0 6 5 1 0 19 12 1 0 17 14 2 0 21 20 1 0 M END > 69245 > J. Med. Chem. 36(10)-1993 1387-1392 > PDE5 > 4.8239 $$$$ SciTegic07090714172D 21 23 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -3.9086 1.5029 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2928 -2.6973 0.0000 O 0 0 -3.9097 3.0028 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -5.2071 0.7519 0.0000 C 0 0 -2.6120 3.7568 0.0000 O 0 0 2.5929 0.7486 0.0000 C 0 0 -5.2093 3.7519 0.0000 C 0 0 -2.6152 5.2576 0.0000 C 0 0 -1.3175 6.0116 0.0000 C 0 0 -6.5067 1.5010 0.0000 C 0 0 -1.3201 7.2116 0.0000 C 0 0 -6.5078 3.0010 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 1 0 5 7 2 0 6 1 1 0 7 3 1 0 8 4 2 0 9 6 2 0 10 15 1 0 11 5 1 0 12 7 1 0 13 6 1 0 14 9 1 0 15 12 2 0 16 9 1 0 17 14 1 0 18 17 1 0 19 13 2 0 20 18 1 0 21 19 1 0 4 5 1 0 16 21 2 0 10 11 2 0 M END > 30232 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 5.0000 $$$$ SciTegic07090714172D 21 24 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -3.9086 -1.5029 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -2.5812 5.2552 0.0000 C 0 0 -3.3239 6.4673 0.0000 C 0 0 -1.8239 6.4583 0.0000 C 0 0 -5.2093 -3.7519 0.0000 N 0 0 -2.5870 3.7544 0.0000 C 0 0 -3.9097 -3.0028 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 5 1 0 7 2 1 0 8 3 1 0 9 13 1 0 10 9 1 0 11 9 1 0 12 14 2 0 13 8 1 0 14 7 1 0 15 5 2 0 16 7 2 0 17 6 2 0 18 19 2 0 19 16 1 0 20 15 1 0 21 20 2 0 4 6 1 0 11 10 1 0 21 17 1 0 12 18 1 0 M END > 25419 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.3565 $$$$ SciTegic07090714172D 21 24 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -3.8580 7.5275 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.5550 8.2605 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -4.9525 8.5435 0.0000 O 0 0 -2.8550 9.7234 0.0000 O 0 0 0.0000 -0.7486 0.0000 C 0 0 -4.3487 9.8872 0.0000 C 0 0 -3.8908 6.0238 0.0000 C 0 0 -1.2530 7.5077 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -1.2768 5.9882 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 13 2 0 5 1 1 0 6 8 2 0 7 14 2 0 8 3 1 0 9 4 1 0 10 7 1 0 11 2 1 0 12 9 1 0 13 15 1 0 14 17 1 0 15 16 1 0 16 5 1 0 17 15 2 0 18 2 2 0 19 11 2 0 20 18 1 0 21 20 2 0 11 6 1 0 21 19 1 0 4 7 1 0 10 12 1 0 M END > 17586 > J. Med. Chem. 37(13)-1994 2106-2111 > PDE5 > 5.3768 $$$$ SciTegic07090714172D 21 25 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 -1.8061 2.5600 0.0000 O 0 0 4.1223 1.1307 0.0000 C 0 0 5.3712 1.8097 0.0000 C 0 0 4.0673 2.5512 0.0000 C 0 0 3.3777 -0.1724 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 3 1 0 9 4 1 0 10 8 2 0 11 1 1 0 12 11 1 0 13 6 2 0 14 17 1 0 15 14 1 0 16 14 1 0 17 10 1 0 18 5 1 0 11 19 1 1 12 20 1 1 21 19 1 0 12 7 1 0 21 20 1 0 9 10 1 0 5 6 1 0 15 16 1 0 M END > 37999 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 6.2147 $$$$ SciTegic07090714172D 22 25 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.1749 2.6315 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 1.3751 3.8801 0.0000 O 0 0 3.6243 2.9682 0.0000 C 0 0 2.3406 5.0280 0.0000 C 0 0 3.7308 4.4644 0.0000 C 0 0 2.1852 -2.6281 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.9829 6.4829 0.0000 C 0 0 2.8483 7.3143 0.0000 O 0 0 1.2781 -3.8165 0.0000 C 0 0 3.6753 -2.8147 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 4.2537 -4.1987 0.0000 C 0 0 1.8565 -5.2005 0.0000 C 0 0 3.3443 -5.3916 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 2 1 0 6 3 1 0 7 4 1 0 8 4 2 0 9 7 1 0 10 8 1 0 11 3 1 0 12 5 2 0 13 6 2 0 14 9 1 0 15 14 1 0 16 11 2 0 17 11 1 0 18 12 1 0 19 13 1 0 20 17 2 0 21 16 1 0 22 20 1 0 6 5 1 0 18 19 2 0 10 9 2 0 21 22 2 0 M END > 89750 > J. Med. Chem. 44(22)-2001 3746-3749 > PDE5 > 4.4401 $$$$ SciTegic07090714172D 22 25 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -7.8173 0.7210 0.0000 C 0 0 -3.9122 1.4966 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -7.8045 -0.7740 0.0000 C 0 0 -9.2432 1.1646 0.0000 O 0 0 -1.2928 2.6973 0.0000 O 0 0 -9.2226 -1.2419 0.0000 O 0 0 -10.1082 -0.0279 0.0000 C 0 0 -6.5294 1.4977 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 -6.5035 -1.5286 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -5.1974 -0.7517 0.0000 C 0 0 3.6321 -1.3486 0.0000 Cl 0 0 2 1 1 0 3 2 1 0 4 6 2 0 5 4 1 0 6 1 1 0 7 3 2 0 8 16 2 0 9 1 1 0 10 5 2 0 11 18 2 0 12 8 1 0 13 2 2 0 14 11 1 0 15 12 1 0 16 17 1 0 17 9 1 0 18 21 1 0 19 10 1 0 20 7 1 0 21 17 2 0 22 19 1 0 3 5 1 0 19 20 2 0 8 11 1 0 14 15 1 0 M END > 17596 > J. Med. Chem. 37(13)-1994 2106-2111 > PDE5 > 5.0605 $$$$ SciTegic07090714172D 22 25 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.5870 3.7544 0.0000 N 0 0 -2.7213 5.2356 0.0000 C 0 0 -3.9399 3.1366 0.0000 C 0 0 -3.9086 -1.5029 0.0000 C 0 0 -4.1878 5.5510 0.0000 C 0 0 -4.9409 4.2538 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.9097 -3.0028 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 -5.2093 -3.7519 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 2 1 2 0 3 2 1 0 4 7 1 0 5 1 1 0 6 1 1 0 7 5 1 0 8 6 1 0 9 8 1 0 10 8 1 0 11 3 1 0 12 9 2 0 13 10 2 0 14 5 2 0 15 7 2 0 16 11 1 0 17 11 2 0 18 14 1 0 19 18 2 0 20 17 1 0 21 16 2 0 22 20 2 0 4 3 2 0 12 13 1 0 19 15 1 0 21 22 1 0 M END > 25382 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.2218 $$$$ SciTegic07090714172D 22 25 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -3.9086 1.5029 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -5.5150 3.2942 0.0000 N 0 0 -4.0476 2.9835 0.0000 C 0 0 -1.2907 -2.9981 0.0000 N 0 0 -5.2594 0.8807 0.0000 C 0 0 -6.2640 1.9946 0.0000 C 0 0 -3.7896 -6.1222 0.0000 O 0 0 -2.5870 -3.7544 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -3.3176 -7.5460 0.0000 C 0 0 -1.3626 -6.1078 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.8176 -7.5371 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 1 2 0 6 7 1 0 7 5 1 0 8 9 2 0 9 3 1 0 10 4 1 0 11 3 1 0 12 11 2 0 13 15 1 0 14 10 1 0 15 14 1 0 16 6 2 0 17 7 2 0 18 13 1 0 19 15 1 0 20 22 2 0 21 19 1 0 22 17 1 0 4 6 1 0 8 12 1 0 20 16 1 0 21 18 1 0 M END > 25423 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.5229 $$$$ SciTegic07090714172D 23 26 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 2.1749 2.6315 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 1.3751 3.8801 0.0000 O 0 0 3.6243 2.9682 0.0000 C 0 0 2.3406 5.0280 0.0000 C 0 0 2.1855 -2.6254 0.0000 C 0 0 3.7308 4.4644 0.0000 C 0 0 3.6552 -2.9294 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.9829 6.4829 0.0000 C 0 0 2.8483 7.3143 0.0000 O 0 0 4.1295 -4.3524 0.0000 C 0 0 4.6506 -1.8071 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.1201 -2.1080 0.0000 C 0 0 5.5991 -4.6533 0.0000 C 0 0 6.5944 -3.5310 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 2 1 0 5 2 1 0 6 3 1 0 7 4 1 0 8 4 2 0 9 7 1 0 10 3 1 0 11 8 1 0 12 10 1 0 13 5 2 0 14 6 2 0 15 9 1 0 16 15 1 0 17 12 2 0 18 12 1 0 19 13 1 0 20 14 1 0 21 18 2 0 22 17 1 0 23 21 1 0 6 5 1 0 19 20 2 0 11 9 2 0 23 22 2 0 M END > 89749 > J. Med. Chem. 44(22)-2001 3746-3749 > PDE5 > 4.4962 $$$$ SciTegic07090714172D 23 27 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 0.9700 1.0600 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 4.1223 1.1307 0.0000 C 0 0 3.3777 -0.1724 0.0000 C 0 0 5.6022 1.2781 0.0000 N 0 0 3.4925 2.4780 0.0000 N 0 0 -1.8061 2.5600 0.0000 O 0 0 5.9046 2.7474 0.0000 C 0 0 4.6007 3.4889 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 3 1 0 9 8 2 0 10 4 1 0 11 1 1 0 12 11 1 0 13 14 1 0 14 9 1 0 15 13 2 0 16 13 1 0 17 6 2 0 18 15 1 0 19 16 1 0 20 5 1 0 11 21 1 1 12 22 1 1 23 21 1 0 12 7 1 0 23 22 1 0 10 9 1 0 5 6 1 0 19 18 2 0 M END > 38025 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 4.5850 $$$$ SciTegic07090714172D 23 26 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -3.9086 -1.5029 0.0000 C 0 0 -3.7896 6.1222 0.0000 O 0 0 -2.5870 3.7544 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.3176 7.5460 0.0000 C 0 0 -3.9097 -3.0028 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 -1.3626 6.1078 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -1.8176 7.5371 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 -5.2093 -3.7519 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 1 0 8 3 1 0 9 11 1 0 10 7 1 0 11 10 1 0 12 5 2 0 13 6 2 0 14 9 1 0 15 8 2 0 16 8 1 0 17 11 1 0 18 12 1 0 19 17 1 0 20 13 1 0 21 16 2 0 22 15 1 0 23 21 1 0 5 6 1 0 22 23 2 0 18 20 2 0 19 14 1 0 M END > 25394 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.0555 $$$$ SciTegic07090714172D 23 26 0 0 0 0 999 V2000 2.5889 0.0182 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 4.0896 0.0290 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 4.9397 -1.2009 0.0000 C 0 0 4.2991 -2.5581 0.0000 O 0 0 5.1534 -3.7921 0.0000 C 0 0 4.7275 1.3885 0.0000 C 0 0 4.5128 -5.1493 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 6.4347 -1.0783 0.0000 C 0 0 5.3649 -6.3839 0.0000 C 0 0 3.0176 -5.2701 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 6.2225 1.5110 0.0000 C 0 0 7.0761 0.2776 0.0000 C 0 0 2.3746 -6.6253 0.0000 C 0 0 4.7219 -7.7390 0.0000 C 0 0 3.2267 -7.8598 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 3 1 0 7 5 2 0 8 4 1 0 9 8 1 0 10 9 1 0 11 4 2 0 12 10 1 0 13 6 2 0 14 7 1 0 15 8 2 0 16 12 2 0 17 12 1 0 18 13 1 0 19 11 1 0 20 19 2 0 21 17 2 0 22 16 1 0 23 21 1 0 6 5 1 0 20 15 1 0 18 14 2 0 23 22 2 0 M END > 69239 > J. Med. Chem. 36(10)-1993 1387-1392 > PDE5 > 5.3979 $$$$ SciTegic07090714172D 23 25 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 1.2995 -2.9981 0.0000 N 0 0 2.6034 -5.2475 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 3.8169 -6.1073 0.0000 O 0 0 1.3899 -6.1074 0.0000 C 0 0 3.3534 -7.5339 0.0000 C 0 0 1.8534 -7.5339 0.0000 C 0 0 2.6003 -3.7467 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 -3.9091 1.5019 0.0000 O 0 0 -3.9091 -1.5019 0.0000 O 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 7 2 0 5 1 1 0 6 1 2 0 7 6 1 0 8 5 2 0 9 3 1 0 10 5 1 0 11 17 1 0 12 8 1 0 13 11 1 0 14 11 2 0 15 13 1 0 16 14 1 0 17 10 1 0 18 2 1 0 19 4 1 0 20 7 1 0 21 18 1 0 22 19 1 0 23 20 1 0 4 2 1 0 12 9 2 0 15 16 2 0 M END > 73432 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 5.3979 $$$$ SciTegic07090714172D 23 26 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -3.9086 1.5029 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -5.5150 3.2942 0.0000 N 0 0 -4.0476 2.9835 0.0000 C 0 0 -1.2907 -2.9981 0.0000 N 0 0 -5.2594 0.8807 0.0000 C 0 0 -6.2640 1.9946 0.0000 C 0 0 -2.5870 -3.7544 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -3.8758 -6.0130 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 -3.8669 -7.5130 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 1 2 0 6 7 1 0 7 5 1 0 8 9 2 0 9 3 1 0 10 4 1 0 11 3 1 0 12 11 2 0 13 10 1 0 14 6 2 0 15 13 1 0 16 7 2 0 17 15 1 0 18 15 2 0 19 20 2 0 20 16 1 0 21 18 1 0 22 17 2 0 23 21 2 0 4 6 1 0 8 12 1 0 19 14 1 0 22 23 1 0 M END > 25420 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 6.5850 $$$$ SciTegic07090714172D 24 26 0 0 0 0 999 V2000 -0.0031 3.0008 0.0000 C 0 0 -1.3039 3.7494 0.0000 N 0 0 1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 1.2990 0.7500 0.0000 C 0 0 -1.3070 5.2502 0.0000 C 0 0 2.6003 -1.4977 0.0000 O 0 0 0.0000 -1.5000 0.0000 C 0 0 1.0351 3.6026 0.0000 O 0 0 -2.6061 6.0003 0.0000 C 0 0 -1.2990 0.7500 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 -3.6453 5.4003 0.0000 O 0 0 3.8990 -0.7455 0.0000 C 0 0 -0.0031 -3.0008 0.0000 O 0 0 -0.0080 6.0003 0.0000 C 0 0 -2.6061 7.5003 0.0000 C 0 0 -1.0432 -3.5994 0.0000 C 0 0 5.2526 -1.3618 0.0000 C 0 0 4.0317 0.7359 0.0000 C 0 0 -0.0080 7.5003 0.0000 C 0 0 -1.3071 8.2503 0.0000 C 0 0 5.4979 1.0528 0.0000 C 0 0 6.2524 -0.2436 0.0000 C 0 0 2 1 1 0 3 5 1 0 4 1 1 0 5 4 2 0 6 2 1 0 7 3 1 0 8 12 1 0 9 1 2 0 10 6 2 0 11 4 1 0 12 11 2 0 13 10 1 0 14 7 1 0 15 8 1 0 16 6 1 0 17 10 1 0 18 15 1 0 19 14 1 0 20 14 1 0 21 16 2 0 22 21 1 0 23 20 1 0 24 19 1 0 3 8 2 0 17 22 2 0 23 24 1 0 M END > 16815 > J. Med. Chem. 37(11)-1994 1696-1703 > PDE5 > 3.7570 $$$$ SciTegic07090714172D 24 27 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -3.9086 -1.5029 0.0000 C 0 0 -3.8758 6.0130 0.0000 N 0 0 -2.5870 3.7544 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.8669 7.5130 0.0000 C 0 0 -3.9097 -3.0028 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 -1.2777 5.9976 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -2.5634 8.2553 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 -5.2093 -3.7519 0.0000 C 0 0 -1.2688 7.4976 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 1 0 8 3 1 0 9 11 1 0 10 7 1 0 11 10 1 0 12 5 2 0 13 6 2 0 14 9 2 0 15 8 1 0 16 8 2 0 17 11 2 0 18 12 1 0 19 13 1 0 20 23 2 0 21 16 1 0 22 15 2 0 23 17 1 0 24 21 2 0 5 6 1 0 22 24 1 0 18 19 2 0 14 20 1 0 M END > 25392 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 4.9586 $$$$ SciTegic07090714172D 24 28 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 0.7500 0.0000 N 0 0 2.4133 -1.7530 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.3115 -2.9665 0.0000 N 0 0 1.8032 -3.1233 0.0000 C 0 0 0.3114 2.9665 0.0000 N 0 0 2.4133 1.7530 0.0000 C 0 0 1.8032 3.1233 0.0000 C 0 0 -2.3383 -1.3500 0.0000 O 0 0 2.5536 -4.4230 0.0000 C 0 0 -2.3383 1.3500 0.0000 C 0 0 2.0572 4.6421 0.0000 C 0 0 3.2153 2.5091 0.0000 C 0 0 1.9048 -5.7699 0.0000 C 0 0 4.0507 -4.3052 0.0000 C 0 0 4.2478 3.5972 0.0000 C 0 0 3.5321 4.9154 0.0000 C 0 0 4.8963 -5.5442 0.0000 C 0 0 2.7505 -7.0088 0.0000 C 0 0 4.2462 -6.8959 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 1 2 0 5 7 1 0 6 1 1 0 7 4 1 0 8 4 1 0 9 6 2 0 10 3 2 0 11 2 1 0 12 11 1 0 13 7 2 0 14 9 1 0 15 5 1 0 16 12 1 0 17 12 1 0 18 14 2 0 19 14 1 0 20 17 1 0 21 16 1 0 22 19 2 0 23 18 1 0 24 22 1 0 8 9 1 0 3 5 1 0 12 10 1 0 20 21 1 0 24 23 2 0 M END > 38009 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 5.4815 $$$$ SciTegic07090714172D 24 28 0 0 0 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 0.9700 -1.4300 0.0000 N 0 0 -4.3000 -1.9800 0.0000 N 0 0 1.8800 -0.1800 0.0000 N 0 0 0.9700 1.0600 0.0000 C 0 0 -2.1400 -3.2100 0.0000 C 0 0 -3.6700 -3.3900 0.0000 C 0 0 1.4315 -2.8550 0.0000 C 0 0 -1.8061 2.5600 0.0000 O 0 0 -4.1977 1.1927 0.0000 C 0 0 2.8990 -3.1695 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 3.3631 -4.5959 0.0000 C 0 0 3.9023 -2.0544 0.0000 C 0 0 5.3697 -2.3657 0.0000 C 0 0 4.8305 -4.9072 0.0000 C 0 0 5.8337 -3.7921 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 3 1 0 8 2 2 0 9 7 1 0 10 4 1 0 11 1 1 0 12 11 1 0 13 7 1 0 14 6 2 0 15 5 1 0 16 13 1 0 17 11 1 0 18 12 1 0 19 17 1 0 20 16 2 0 21 16 1 0 22 21 2 0 23 20 1 0 24 22 1 0 8 12 1 0 18 19 1 0 9 10 2 0 5 6 1 0 23 24 2 0 M END > 40870 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 5.5086 $$$$ SciTegic07090714172D 24 28 0 0 0 0 999 V2000 1.9924 -0.6682 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 0.7168 1.5915 0.0000 C 0 0 -0.5831 -0.6682 0.0000 C 0 0 4.6043 -0.6682 0.0000 N 0 0 -0.5831 0.8382 0.0000 C 0 0 5.9253 -7.4259 0.0000 C 0 0 3.3044 1.5915 0.0000 N 0 0 3.3133 -2.9221 0.0000 N 0 0 4.6296 -8.1717 0.0000 C 0 0 -2.0045 -1.1298 0.0000 O 0 0 -2.0045 1.2999 0.0000 O 0 0 4.6043 0.8382 0.0000 C 0 0 7.0298 -8.4310 0.0000 O 0 0 4.9441 -9.6316 0.0000 O 0 0 -2.8792 0.0850 0.0000 C 0 0 6.4393 -9.7806 0.0000 C 0 0 5.9432 -5.9220 0.0000 C 0 0 3.3202 -7.4318 0.0000 C 0 0 4.6261 -5.1663 0.0000 C 0 0 4.6171 -3.6655 0.0000 C 0 0 3.3290 -5.9121 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 1 2 0 5 3 2 0 6 4 1 0 7 2 2 0 8 6 2 0 9 20 2 0 10 3 1 0 11 2 1 0 12 21 2 0 13 6 1 0 14 8 1 0 15 10 2 0 16 9 1 0 17 12 1 0 18 13 1 0 19 16 1 0 20 22 1 0 21 24 1 0 22 23 1 0 23 11 1 0 24 22 2 0 5 8 1 0 15 7 1 0 18 14 1 0 9 12 1 0 17 19 1 0 M END > 17592 > J. Med. Chem. 37(13)-1994 2106-2111 > PDE5 > 5.7959 $$$$ SciTegic07090714172D 24 27 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -3.9086 1.5029 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -5.5150 3.2942 0.0000 N 0 0 -4.0476 2.9835 0.0000 C 0 0 -5.2594 0.8807 0.0000 C 0 0 -6.2640 1.9946 0.0000 C 0 0 -1.2907 -2.9981 0.0000 N 0 0 -2.5870 -3.7544 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.8775 -6.0115 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 -3.8739 -7.5115 0.0000 C 0 0 -5.1785 -5.2648 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -6.4757 -6.0180 0.0000 C 0 0 -5.1711 -8.2648 0.0000 C 0 0 -6.4720 -7.5180 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 2 0 5 1 2 0 6 7 1 0 7 5 1 0 8 9 2 0 9 3 1 0 10 3 1 0 11 10 2 0 12 4 1 0 13 12 1 0 14 6 2 0 15 17 1 0 16 7 2 0 17 13 1 0 18 15 2 0 19 15 1 0 20 21 2 0 21 16 1 0 22 19 2 0 23 18 1 0 24 22 1 0 4 6 1 0 8 11 1 0 20 14 1 0 23 24 2 0 M END > 25425 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 6.0655 $$$$ SciTegic07090714172D 24 28 0 0 0 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 1.0600 0.0000 C 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 -3.6700 -3.3900 0.0000 C 0 0 -1.8061 2.5600 0.0000 O 0 0 1.4303 2.4855 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 2.8975 2.8012 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 3.3605 4.2280 0.0000 C 0 0 3.9018 1.6869 0.0000 C 0 0 5.3689 1.9995 0.0000 C 0 0 4.8276 4.5405 0.0000 C 0 0 5.8318 3.4263 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 4 1 0 9 3 1 0 10 9 1 0 11 1 1 0 12 11 1 0 13 6 2 0 14 8 1 0 15 5 1 0 16 14 1 0 17 11 1 0 18 12 1 0 19 17 1 0 20 16 2 0 21 16 1 0 22 21 2 0 23 20 1 0 24 22 1 0 7 12 1 0 18 19 1 0 10 8 2 0 5 6 1 0 23 24 2 0 M END > 40873 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 6.7212 $$$$ SciTegic07090714172D 24 27 0 0 0 0 999 V2000 -2.3414 -0.5743 0.0000 C 0 0 -1.5683 0.7068 0.0000 N 0 0 0.6627 -0.5522 0.0000 C 0 0 0.0000 0.7068 0.0000 C 0 0 -1.6125 -1.8776 0.0000 N 0 0 0.0000 -1.8555 0.0000 C 0 0 2.1205 -0.2651 0.0000 C 0 0 0.9498 1.8334 0.0000 N 0 0 2.2973 1.1928 0.0000 N 0 0 -3.8214 -0.2430 0.0000 N 0 0 -2.5402 1.8334 0.0000 C 0 0 -3.9539 1.2370 0.0000 C 0 0 3.2231 -1.2799 0.0000 C 0 0 0.6344 -2.8741 0.0000 O 0 0 -2.2125 -2.9168 0.0000 C 0 0 3.3485 1.7715 0.0000 C 0 0 4.6557 -0.8326 0.0000 C 0 0 -3.9151 2.4364 0.0000 C 0 0 -4.9949 0.6400 0.0000 C 0 0 5.7609 -1.8468 0.0000 C 0 0 4.9816 0.6317 0.0000 C 0 0 6.4126 1.0816 0.0000 C 0 0 7.1919 -1.3968 0.0000 C 0 0 7.5177 0.0673 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 2 1 0 5 1 1 0 6 5 1 0 7 3 2 0 8 4 2 0 9 8 1 0 10 1 2 0 11 2 1 0 12 10 1 0 13 7 1 0 14 6 2 0 15 5 1 0 16 9 1 0 17 13 1 0 18 12 1 0 19 12 1 0 20 17 1 0 21 17 2 0 22 21 1 0 23 20 2 0 24 22 2 0 11 12 1 0 3 4 1 0 9 7 1 0 23 24 1 0 M END > 40878 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 6.8539 $$$$ SciTegic07090714172D 24 28 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 -1.8061 2.5600 0.0000 O 0 0 3.3777 -0.1724 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 4.1223 1.1307 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 5.6223 1.1405 0.0000 C 0 0 3.3639 2.4249 0.0000 C 0 0 4.1055 3.7288 0.0000 C 0 0 6.3639 2.4443 0.0000 C 0 0 5.6055 3.7385 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 3 1 0 9 4 1 0 10 8 2 0 11 1 1 0 12 11 1 0 13 6 2 0 14 10 1 0 15 5 1 0 16 14 1 0 11 17 1 1 12 18 1 1 19 17 1 0 20 16 2 0 21 16 1 0 22 21 2 0 23 20 1 0 24 22 1 0 7 12 1 0 18 19 1 0 10 9 1 0 5 6 1 0 23 24 2 0 M END > 40882 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 7.0969 $$$$ SciTegic07090714172D 24 27 0 0 0 0 999 V2000 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 N 0 0 3.3044 -1.4214 0.0000 N 0 0 1.9924 0.8382 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 5.9046 -1.4175 0.0000 C 0 0 0.7168 1.5915 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -2.0045 1.2999 0.0000 N 0 0 -0.5831 0.8382 0.0000 C 0 0 -0.5831 -0.6682 0.0000 C 0 0 -2.8792 0.0850 0.0000 C 0 0 -2.0045 -1.1298 0.0000 N 0 0 3.3068 2.7915 0.0000 O 0 0 5.9074 -2.9176 0.0000 C 0 0 7.2023 -0.6653 0.0000 C 0 0 4.6106 -3.6731 0.0000 O 0 0 7.2078 -3.6653 0.0000 C 0 0 4.6155 -5.1740 0.0000 C 0 0 3.3188 -5.9295 0.0000 C 0 0 8.5027 -1.4129 0.0000 C 0 0 3.3227 -7.1295 0.0000 C 0 0 8.5055 -2.9129 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 6 2 0 5 2 1 0 6 3 1 0 7 1 1 0 8 4 1 0 9 6 1 0 10 11 1 0 11 12 1 0 12 9 2 0 13 14 1 0 14 12 1 0 15 5 2 0 16 7 2 0 17 7 1 0 18 16 1 0 19 16 1 0 20 18 1 0 21 20 1 0 22 17 2 0 23 21 1 0 24 22 1 0 5 4 1 0 19 24 2 0 11 8 2 0 13 10 2 0 M END > 57761 > J. Med. Chem. 43(7)-2000 1257-1263 > PDE5 > 7.3565 $$$$ SciTegic07090714172D 24 28 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 -0.3114 -2.9665 0.0000 N 0 0 2.7248 1.2135 0.0000 N 0 0 -2.4133 -1.7530 0.0000 N 0 0 -1.8032 -3.1233 0.0000 C 0 0 2.7248 -1.2135 0.0000 C 0 0 3.6065 0.0000 0.0000 C 0 0 -2.3383 1.3500 0.0000 O 0 0 -2.5550 -4.4193 0.0000 C 0 0 0.0000 2.7000 0.0000 C 0 0 -4.0559 -4.4171 0.0000 C 0 0 5.0487 0.5394 0.0000 C 0 0 3.7806 -1.5300 0.0000 C 0 0 -4.9199 -5.6276 0.0000 C 0 0 -4.9114 -3.2006 0.0000 C 0 0 5.2392 -1.8801 0.0000 C 0 0 6.0229 -0.6012 0.0000 C 0 0 -6.3396 -3.6591 0.0000 C 0 0 -6.3449 -5.1591 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 3 1 0 8 2 2 0 9 4 1 0 10 7 2 0 11 1 1 0 12 11 1 0 13 6 2 0 14 10 1 0 15 5 1 0 16 14 1 0 17 12 1 0 18 12 1 0 19 16 1 0 20 16 1 0 21 18 1 0 22 17 1 0 23 20 1 0 24 19 1 0 12 8 1 0 9 10 1 0 6 5 1 0 22 21 1 0 23 24 1 0 M END > 38003 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 7.5850 $$$$ SciTegic07090714172D 25 27 0 0 0 0 999 V2000 -1.2919 2.9980 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.5891 3.7515 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5853 5.2515 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -1.2844 5.9982 0.0000 N 0 0 2.5929 -0.7486 0.0000 C 0 0 0.0089 3.7449 0.0000 C 0 0 0.0127 5.2449 0.0000 C 0 0 -3.6230 5.8542 0.0000 O 0 0 3.8911 1.5017 0.0000 O 0 0 3.8911 -1.5017 0.0000 O 0 0 -3.9122 1.4966 0.0000 C 0 0 -3.9091 -1.5019 0.0000 C 0 0 -4.9506 0.8952 0.0000 O 0 0 -3.9072 -2.7019 0.0000 O 0 0 3.8894 2.7017 0.0000 C 0 0 3.8894 -2.7017 0.0000 C 0 0 2 3 1 0 3 1 1 0 4 2 1 0 5 1 2 0 6 3 2 0 7 2 2 0 8 5 1 0 9 6 1 0 10 9 2 0 11 7 1 0 12 4 2 0 13 16 1 0 14 11 2 0 15 1 1 0 16 15 2 0 17 8 2 0 18 11 1 0 19 14 1 0 20 6 1 0 21 9 1 0 22 20 1 0 23 21 1 0 24 18 1 0 25 19 1 0 8 13 1 0 10 4 1 0 12 14 1 0 M END > 31672 > J. Med. Chem. 39(14)-1996 2696-2704 > PDE5 > 5.0000 $$$$ SciTegic07090714172D 25 27 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 N 0 0 3.9072 5.9922 0.0000 C 0 0 1.2995 2.9981 0.0000 C 0 0 5.2037 5.2377 0.0000 C 0 0 2.6056 5.2467 0.0000 C 0 0 2.6003 3.7467 0.0000 C 0 0 5.1985 3.7377 0.0000 C 0 0 3.8969 2.9922 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -3.9091 1.5019 0.0000 O 0 0 -3.9091 -1.5019 0.0000 O 0 0 3.9093 7.4931 0.0000 O 0 0 6.5076 5.9810 0.0000 O 0 0 1.2964 -1.4973 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 2.8713 8.0952 0.0000 C 0 0 7.5438 5.3759 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 3 1 0 6 7 1 0 7 4 2 0 8 2 2 0 9 12 1 0 10 2 1 0 11 14 1 0 12 13 2 0 13 10 1 0 14 15 2 0 15 13 1 0 16 21 2 0 17 5 1 0 18 6 1 0 19 9 1 0 20 11 1 0 21 4 1 0 22 18 1 0 23 17 1 0 24 19 1 0 25 20 1 0 16 8 1 0 6 5 2 0 11 9 2 0 M END > 73440 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 5.0555 $$$$ SciTegic07090714172D 25 29 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 3.3777 -0.1755 0.0000 C 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 4.8785 -0.1710 0.0000 C 0 0 -1.8061 2.5600 0.0000 O 0 0 -4.1977 1.1927 0.0000 C 0 0 6.3793 -0.1665 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 7.1332 -1.4633 0.0000 C 0 0 7.1254 1.1348 0.0000 C 0 0 8.6254 1.1393 0.0000 C 0 0 8.6332 -1.4588 0.0000 C 0 0 9.3793 -0.1575 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 3 1 0 9 4 1 0 10 8 2 0 11 1 1 0 12 10 1 0 13 11 1 0 14 12 3 0 15 6 2 0 16 5 1 0 17 14 1 0 11 18 1 1 13 19 1 1 20 18 1 0 21 17 2 0 22 17 1 0 23 22 2 0 24 21 1 0 25 23 1 0 13 7 1 0 20 19 1 0 9 10 1 0 5 6 1 0 25 24 2 0 M END > 38027 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 5.2218 $$$$ SciTegic07090714172D 25 28 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -3.8775 6.0115 0.0000 C 0 0 -3.9086 -1.5029 0.0000 C 0 0 -4.0118 7.4927 0.0000 C 0 0 -5.2305 5.3938 0.0000 N 0 0 -6.2314 6.5110 0.0000 C 0 0 -5.4782 7.8082 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -5.2093 -3.7519 0.0000 N 0 0 -2.5812 5.2552 0.0000 C 0 0 -3.9097 -3.0028 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 -3.1133 8.2881 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 5 1 0 7 15 1 0 8 2 1 0 9 7 2 0 10 7 1 0 11 10 1 0 12 9 1 0 13 3 1 0 14 16 2 0 15 17 1 0 16 8 1 0 17 13 1 0 18 5 2 0 19 8 2 0 20 9 1 0 21 6 2 0 22 23 2 0 23 19 1 0 24 18 1 0 25 24 2 0 6 4 1 0 21 25 1 0 14 22 1 0 11 12 2 0 M END > 25427 > J. Med. Chem. 38(18)-1995 3547-3557 > PDE5 > 5.9586 $$$$ SciTegic07090714172D 25 28 0 0 1 0 999 V2000 -3.8985 3.0030 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -3.9086 1.5029 0.0000 C 0 0 -5.1925 3.7616 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 -6.4965 3.0203 0.0000 C 0 0 1.2995 -2.9981 0.0000 N 0 0 -5.2125 0.7617 0.0000 C 0 0 2 0 0 0 -1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 1.4973 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 -6.5065 1.5203 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -7.5317 3.6272 0.0000 O 0 0 2.6003 -3.7467 0.0000 C 0 0 -5.2206 -0.4383 0.0000 C 0 0 2.6056 -5.2467 0.0000 C 0 0 3.8969 -2.9922 0.0000 C 0 0 5.1985 -3.7377 0.0000 C 0 0 3.9072 -5.9922 0.0000 C 0 0 5.2037 -5.2377 0.0000 C 0 0 2 3 2 0 3 13 1 0 4 1 2 0 5 1 1 0 6 12 1 0 7 4 1 0 8 2 1 0 9 5 1 0 10 2 1 0 11 4 1 0 12 7 2 0 13 17 2 0 14 6 2 0 15 14 1 0 16 9 1 0 17 7 1 0 18 9 2 0 19 10 1 0 11 20 1 1 21 19 2 0 22 19 1 0 23 22 2 0 24 21 1 0 25 23 1 0 16 11 1 0 6 3 1 0 15 8 2 0 24 25 2 0 M END > 28408 > J. Med. Chem. 39(1)-1996 297-303 > PDE5 > 6.0000 $$$$ SciTegic07090714172D 25 27 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -0.9971 3.0138 0.0000 N 0 0 -3.5736 7.5284 0.0000 C 0 0 -2.2702 8.2708 0.0000 C 0 0 -4.6560 0.8780 0.0000 O 0 0 -3.5824 6.0284 0.0000 C 0 0 -0.9756 7.5132 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -2.2878 5.2708 0.0000 C 0 0 -4.6093 8.1345 0.0000 Cl 0 0 -3.6319 2.6865 0.0000 O 0 0 -0.9844 6.0132 0.0000 C 0 0 2.1855 -2.6254 0.0000 C 0 0 -2.2584 9.7716 0.0000 O 0 0 -1.2148 10.3640 0.0000 C 0 0 3.3606 -2.8684 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 8 2 0 6 2 2 0 7 2 1 0 8 1 1 0 9 4 1 0 10 4 2 0 11 3 1 0 12 15 2 0 13 16 2 0 14 9 2 0 15 18 1 0 16 21 1 0 17 11 1 0 18 17 1 0 19 12 1 0 20 9 1 0 21 18 2 0 22 7 1 0 23 13 1 0 24 23 1 0 25 22 1 0 7 5 1 0 10 6 1 0 13 12 1 0 M END > 85934 > J. Med. Chem. 45(7)-2001 1025-1027 > PDE5 > 7.4202 $$$$ SciTegic07090714172D 25 29 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 N 0 0 1.2990 0.7500 0.0000 C 0 0 0.0000 -1.5000 0.0000 C 0 0 -1.2990 -0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 -0.3114 -2.9665 0.0000 N 0 0 2.7248 1.2135 0.0000 N 0 0 -2.4133 -1.7530 0.0000 N 0 0 -1.8032 -3.1233 0.0000 C 0 0 2.7248 -1.2135 0.0000 C 0 0 3.6065 0.0000 0.0000 C 0 0 -2.3383 1.3500 0.0000 O 0 0 -2.5550 -4.4193 0.0000 C 0 0 0.0000 2.7000 0.0000 C 0 0 -4.0559 -4.4171 0.0000 C 0 0 5.0487 0.5394 0.0000 C 0 0 3.7806 -1.5300 0.0000 C 0 0 -4.8105 -5.7135 0.0000 C 0 0 -4.8014 -3.1154 0.0000 C 0 0 5.2392 -1.8801 0.0000 C 0 0 6.0229 -0.6012 0.0000 C 0 0 -6.3014 -3.1102 0.0000 C 0 0 -6.3105 -5.7083 0.0000 C 0 0 -7.0559 -4.4067 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 3 1 0 8 2 2 0 9 4 1 0 10 7 2 0 11 1 1 0 12 11 1 0 13 6 2 0 14 10 1 0 15 5 1 0 16 14 1 0 17 12 1 0 18 12 1 0 19 16 2 0 20 16 1 0 21 18 1 0 22 17 1 0 23 20 2 0 24 19 1 0 25 23 1 0 12 8 1 0 9 10 1 0 6 5 1 0 22 21 1 0 25 24 2 0 M END > 38013 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 7.7212 $$$$ SciTegic07090714172D 26 29 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2995 -2.9981 0.0000 N 0 0 3.9242 -5.9919 0.0000 C 0 0 1.2964 1.4973 0.0000 N 0 0 2.6075 -5.2651 0.0000 C 0 0 5.2124 -5.2331 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 4.2533 -7.4485 0.0000 O 0 0 2.6003 -3.7467 0.0000 C 0 0 6.3269 -6.2271 0.0000 O 0 0 5.7185 -7.6011 0.0000 C 0 0 5.2152 -3.7291 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 -3.9091 1.5019 0.0000 O 0 0 3.8892 -2.9867 0.0000 C 0 0 -3.9091 -1.5019 0.0000 O 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 4 2 0 3 1 1 0 4 1 1 0 5 7 2 0 6 1 2 0 7 6 1 0 8 3 2 0 9 3 1 0 10 12 2 0 11 4 1 0 12 16 1 0 13 19 2 0 14 11 2 0 15 10 1 0 16 9 1 0 17 13 1 0 18 15 1 0 19 22 1 0 20 2 1 0 21 5 1 0 22 16 2 0 23 7 1 0 24 20 1 0 25 21 1 0 26 23 1 0 5 2 1 0 14 8 1 0 10 13 1 0 17 18 1 0 M END > 73414 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 4.9586 $$$$ SciTegic07090714172D 26 30 0 0 0 0 999 V2000 1.2990 -0.7500 0.0000 C 0 0 1.2990 0.7500 0.0000 N 0 0 -1.2990 0.7500 0.0000 C 0 0 0.0000 1.5000 0.0000 C 0 0 0.0000 -1.5000 0.0000 N 0 0 -1.2990 -0.7500 0.0000 C 0 0 -2.4133 1.7530 0.0000 C 0 0 -0.3115 2.9665 0.0000 N 0 0 -1.8032 3.1233 0.0000 N 0 0 2.7248 -1.2135 0.0000 N 0 0 2.7248 1.2135 0.0000 C 0 0 3.6065 0.0000 0.0000 C 0 0 -3.8794 1.4442 0.0000 C 0 0 -2.3383 -1.3500 0.0000 O 0 0 0.0000 -2.7000 0.0000 C 0 0 -2.4032 4.1625 0.0000 C 0 0 -4.8823 2.5608 0.0000 C 0 0 5.0487 0.5394 0.0000 C 0 0 3.7806 -1.5300 0.0000 C 0 0 -6.3506 2.2538 0.0000 C 0 0 -4.4142 3.9859 0.0000 C 0 0 5.2392 -1.8801 0.0000 C 0 0 6.0229 -0.6012 0.0000 C 0 0 -5.4142 5.1039 0.0000 C 0 0 -7.3506 3.3718 0.0000 C 0 0 -6.8824 4.7969 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 2 1 0 5 1 1 0 6 5 1 0 7 3 2 0 8 4 2 0 9 8 1 0 10 1 2 0 11 2 1 0 12 10 1 0 13 7 1 0 14 6 2 0 15 5 1 0 16 9 1 0 17 13 1 0 18 12 1 0 19 12 1 0 20 17 1 0 21 17 2 0 22 19 1 0 23 18 1 0 24 21 1 0 25 20 2 0 26 24 2 0 11 12 1 0 3 4 1 0 23 22 1 0 9 7 1 0 25 26 1 0 M END > 40877 > J. Med. Chem. 40(26)-1997 4372-4377 > PDE5 > 7.1249 $$$$ SciTegic07090714172D 26 30 0 0 1 0 999 V2000 5.0451 1.0438 0.0000 N 0 0 6.4368 1.5831 0.0000 C 0 0 2.9748 -0.5567 0.0000 C 0 0 6.3672 3.0792 0.0000 N 0 0 2.0354 0.6089 0.0000 C 0 0 4.0708 2.2442 0.0000 C 0 0 1 0 0 0 4.4536 -0.3479 0.0000 C 0 0 2 0 0 0 2.1572 -1.8093 0.0000 N 0 0 4.8885 3.5141 0.0000 C 0 0 2.5921 1.9832 0.0000 C 0 0 0.6437 0.0870 0.0000 C 0 0 0.6959 -1.3917 0.0000 C 0 0 5.3673 -1.5385 0.0000 C 0 0 7.4423 0.9282 0.0000 O 0 0 4.4698 4.6387 0.0000 O 0 0 6.8540 -1.3354 0.0000 C 0 0 4.8007 -2.9273 0.0000 C 0 0 7.2060 -3.9095 0.0000 C 0 0 5.7198 -4.1127 0.0000 C 0 0 7.7731 -2.5208 0.0000 C 0 0 -0.6611 0.8176 0.0000 C 0 0 8.1280 -5.0937 0.0000 O 0 0 -0.5741 -2.1572 0.0000 C 0 0 9.3167 -4.9294 0.0000 C 0 0 -1.9484 0.0348 0.0000 C 0 0 -1.8788 -1.4265 0.0000 C 0 0 2 1 1 0 3 7 1 0 4 2 1 0 5 3 2 0 6 1 1 0 7 1 1 0 8 3 1 0 6 9 1 6 10 6 1 0 11 5 1 0 12 8 1 0 7 13 1 1 14 2 2 0 15 9 2 0 16 13 2 0 17 13 1 0 18 19 1 0 19 17 2 0 20 16 1 0 21 11 2 0 22 18 1 0 23 12 2 0 24 22 1 0 25 21 1 0 26 23 1 0 10 5 1 0 9 4 1 0 18 20 2 0 12 11 1 0 26 25 2 0 M END > 114278 > J. Med. Chem. 46(21)-2003 4525-4532 > PDE5 > 7.6990 $$$$ SciTegic07090714172D 27 31 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -0.9971 -3.0138 0.0000 C 0 0 -3.6187 1.4919 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 -3.3560 -1.3452 0.0000 O 0 0 -0.9991 2.7132 0.0000 O 0 0 -2.2935 -3.7700 0.0000 C 0 0 -3.6267 2.9927 0.0000 C 0 0 -4.3805 4.1979 0.0000 C 0 0 -2.9615 -5.0248 0.0000 C 0 0 -3.7145 -3.7275 0.0000 C 0 0 -2.8805 4.2027 0.0000 C 0 0 3.7889 0.0269 0.0000 N 0 0 3.6500 2.9355 0.0000 C 0 0 4.1200 4.3600 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 6.1174 2.1217 0.0000 C 0 0 5.5886 4.6654 0.0000 C 0 0 6.5873 3.5462 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 6 1 0 5 1 1 0 6 3 1 0 7 2 1 0 8 2 1 0 9 5 2 0 10 3 1 0 11 4 1 0 12 8 1 0 13 6 2 0 14 7 2 0 15 10 1 0 16 11 1 0 17 16 1 0 18 15 1 0 19 15 1 0 20 16 1 0 21 9 1 0 22 12 1 0 23 22 2 0 24 22 1 0 25 24 2 0 26 23 1 0 27 25 1 0 9 8 1 0 7 4 1 0 19 18 1 0 17 20 1 0 26 27 2 0 M END > 15209 > J. Med. Chem. 37(4)-1994 476-485 > PDE5A > 6.0757 $$$$ SciTegic07090714172D 27 30 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9245 5.2428 0.0000 C 0 0 -4.9211 3.7421 0.0000 C 0 0 -3.7143 6.1073 0.0000 S 0 0 -4.9144 0.7421 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -6.1413 6.0980 0.0000 C 0 0 -4.1832 7.5321 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 -5.6832 7.5264 0.0000 C 0 0 -6.2151 1.4892 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2132 -3.0110 0.0000 C 0 0 -7.2520 -3.6117 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 1 1 0 7 5 1 0 8 6 1 0 9 3 1 0 10 4 1 0 11 10 1 0 12 13 1 0 13 11 2 0 14 12 1 0 15 10 2 0 16 5 2 0 17 12 2 0 18 14 1 0 19 21 2 0 20 17 1 0 21 15 1 0 22 6 1 0 23 9 1 0 24 15 1 0 25 24 1 0 26 25 1 0 27 26 1 0 8 9 2 0 7 4 1 0 19 13 1 0 18 20 2 0 M END > 30274 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 6.5229 $$$$ SciTegic07090714172D 27 31 0 0 1 0 999 V2000 6.4368 1.5831 0.0000 C 0 0 5.0451 1.0438 0.0000 N 0 0 6.3672 3.0792 0.0000 N 0 0 2.9748 -0.5567 0.0000 C 0 0 2.0354 0.6089 0.0000 C 0 0 4.8885 3.5141 0.0000 C 0 0 4.4536 -0.3479 0.0000 C 0 0 1 0 0 0 4.0708 2.2442 0.0000 C 0 0 1 0 0 0 2.1572 -1.8093 0.0000 N 0 0 2.5921 1.9832 0.0000 C 0 0 0.6437 0.0870 0.0000 C 0 0 5.3673 -1.5385 0.0000 C 0 0 0.6959 -1.3917 0.0000 C 0 0 7.4423 0.9282 0.0000 O 0 0 4.4698 4.6387 0.0000 O 0 0 6.8536 -1.4741 0.0000 C 0 0 4.9359 -2.9618 0.0000 C 0 0 7.3618 -2.8854 0.0000 O 0 0 6.1765 -3.8048 0.0000 C 0 0 7.5493 3.9997 0.0000 C 0 0 -0.6611 0.8176 0.0000 C 0 0 -0.5741 -2.1572 0.0000 C 0 0 7.3440 5.4865 0.0000 C 0 0 8.5283 6.4084 0.0000 C 0 0 -1.9484 0.0348 0.0000 C 0 0 -1.8788 -1.4265 0.0000 C 0 0 8.3641 7.5971 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 7 1 0 5 10 1 0 6 3 1 0 7 2 1 0 8 2 1 0 9 4 1 0 10 8 1 0 11 5 1 0 7 12 1 6 13 9 1 0 14 1 2 0 15 6 2 0 16 12 2 0 17 12 1 0 18 16 1 0 19 17 2 0 20 3 1 0 21 11 2 0 22 13 2 0 23 20 1 0 24 23 1 0 25 21 1 0 26 22 1 0 27 24 1 0 8 6 1 6 5 4 2 0 18 19 1 0 13 11 1 0 26 25 2 0 M END > 114264 > J. Med. Chem. 46(21)-2003 4525-4532 > PDE5 > 7.0000 $$$$ SciTegic07090714172D 27 32 0 0 1 0 999 V2000 5.0451 1.0438 0.0000 N 0 0 2.9748 -0.5567 0.0000 C 0 0 6.4368 1.5831 0.0000 C 0 0 2.0354 0.6089 0.0000 C 0 0 4.4536 -0.3479 0.0000 C 0 0 1 0 0 0 2.1572 -1.8093 0.0000 N 0 0 6.3672 3.0792 0.0000 N 0 0 4.0708 2.2442 0.0000 C 0 0 2 0 0 0 5.3673 -1.5385 0.0000 C 0 0 2.5921 1.9832 0.0000 C 0 0 0.6437 0.0870 0.0000 C 0 0 0.6959 -1.3917 0.0000 C 0 0 4.8885 3.5141 0.0000 C 0 0 6.8725 -1.3347 0.0000 C 0 0 7.7751 -2.5378 0.0000 C 0 0 7.4423 0.9282 0.0000 O 0 0 7.2026 -3.9188 0.0000 C 0 0 9.2633 -2.6613 0.0000 O 0 0 8.3417 -4.8844 0.0000 O 0 0 4.7941 -2.9204 0.0000 C 0 0 9.6179 -4.0911 0.0000 C 0 0 5.7135 -4.1305 0.0000 C 0 0 7.3111 3.8203 0.0000 C 0 0 -0.6611 0.8176 0.0000 C 0 0 -0.5741 -2.1572 0.0000 C 0 0 -1.9484 0.0348 0.0000 C 0 0 -1.8788 -1.4265 0.0000 C 0 0 2 5 1 0 3 1 1 0 4 10 1 0 5 1 1 0 6 2 1 0 7 3 1 0 8 1 1 0 5 9 1 6 10 8 1 0 11 4 1 0 12 6 1 0 8 13 1 6 14 9 2 0 15 14 1 0 16 3 2 0 17 22 1 0 18 15 1 0 19 17 1 0 20 9 1 0 21 18 1 0 22 20 2 0 23 7 1 0 24 11 2 0 25 12 2 0 26 24 1 0 27 25 1 0 13 7 1 0 4 2 2 0 12 11 1 0 17 15 2 0 19 21 1 0 27 26 2 0 M END > 114294 > J. Med. Chem. 46(21)-2003 4533-4542 > PDE5 > 7.2218 $$$$ SciTegic07090714172D 28 31 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 -2.6111 0.7486 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -9.1185 1.5076 0.0000 C 0 0 -9.1105 3.0026 0.0000 C 0 0 -10.5430 1.0594 0.0000 O 0 0 -1.2928 2.6973 0.0000 O 0 0 -10.5301 3.4660 0.0000 O 0 0 -3.9122 1.4966 0.0000 C 0 0 -11.4118 2.2492 0.0000 C 0 0 -7.8282 0.7349 0.0000 C 0 0 -7.8119 3.7614 0.0000 C 0 0 1.2995 -2.9981 0.0000 O 0 0 3.8911 -1.5017 0.0000 O 0 0 -6.5121 1.4924 0.0000 C 0 0 3.8911 1.5017 0.0000 O 0 0 -5.2109 0.7445 0.0000 C 0 0 -6.5034 2.9886 0.0000 C 0 0 2.3396 -3.5967 0.0000 C 0 0 3.8894 -2.7017 0.0000 C 0 0 3.8894 2.7017 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 2 1 0 5 3 1 0 6 2 2 0 7 10 2 0 8 5 1 0 9 1 2 0 10 9 1 0 11 18 1 0 12 19 1 0 13 11 1 0 14 3 2 0 15 12 1 0 16 5 1 0 17 13 1 0 18 22 2 0 19 25 2 0 20 6 1 0 21 7 1 0 22 24 1 0 23 10 1 0 24 16 1 0 25 22 1 0 26 20 1 0 27 21 1 0 28 23 1 0 7 6 1 0 8 4 2 0 11 12 2 0 15 17 1 0 M END > 73435 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 4.4949 $$$$ SciTegic07090714172D 28 30 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 7.8084 -8.2357 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 6.5076 -7.4871 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 7.8108 -9.4357 0.0000 O 0 0 8.8466 -7.6339 0.0000 O 0 0 1.2995 -2.9981 0.0000 N 0 0 5.2111 -8.2416 0.0000 C 0 0 6.5024 -5.9871 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 -3.9091 1.5019 0.0000 O 0 0 -3.9091 -1.5019 0.0000 O 0 0 3.9095 -7.4961 0.0000 C 0 0 5.2008 -5.2416 0.0000 C 0 0 3.9042 -5.9961 0.0000 C 0 0 2.6003 -3.7467 0.0000 C 0 0 2.6034 -5.2475 0.0000 C 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 4 2 0 3 11 1 0 4 1 1 0 5 8 2 0 6 1 2 0 7 1 1 0 8 6 1 0 9 7 2 0 10 4 1 0 11 17 2 0 12 9 1 0 13 3 2 0 14 3 2 0 15 7 1 0 16 21 2 0 17 22 1 0 18 2 1 0 19 5 1 0 20 8 1 0 21 23 1 0 22 23 2 0 23 25 1 0 24 15 1 0 25 24 1 0 26 18 1 0 27 19 1 0 28 20 1 0 12 10 2 0 5 2 1 0 11 16 1 0 M END > 73423 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 4.6576 $$$$ SciTegic07090714172D 28 30 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -3.9122 1.4966 0.0000 C 0 0 -5.2109 0.7445 0.0000 C 0 0 -1.2928 2.6973 0.0000 O 0 0 -6.5125 1.4901 0.0000 C 0 0 1.2995 -2.9981 0.0000 O 0 0 3.8911 -1.5017 0.0000 O 0 0 3.8911 1.5017 0.0000 O 0 0 -6.5206 2.9910 0.0000 O 0 0 -5.2061 -0.7556 0.0000 C 0 0 -7.8091 0.7359 0.0000 C 0 0 2.3396 -3.5967 0.0000 C 0 0 -7.8239 3.7352 0.0000 C 0 0 3.8894 -2.7017 0.0000 C 0 0 3.8894 2.7017 0.0000 C 0 0 -7.8320 5.2360 0.0000 C 0 0 -6.5027 -1.5098 0.0000 C 0 0 -8.8740 5.8310 0.0000 C 0 0 -7.8042 -0.7641 0.0000 C 0 0 2 3 1 0 3 1 1 0 4 1 1 0 5 4 1 0 6 4 2 0 7 5 2 0 8 10 2 0 9 1 2 0 10 9 1 0 11 2 1 0 12 11 1 0 13 3 2 0 14 12 1 0 15 6 1 0 16 8 1 0 17 10 1 0 18 14 1 0 19 12 2 0 20 14 2 0 21 15 1 0 22 18 1 0 23 16 1 0 24 17 1 0 25 22 1 0 26 19 1 0 27 25 1 0 28 26 2 0 8 6 1 0 2 7 1 0 28 20 1 0 M END > 73436 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 4.9586 $$$$ SciTegic07090714172D 28 31 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 5.2281 -8.2412 0.0000 C 0 0 6.5163 -7.4825 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 5.5572 -9.6979 0.0000 O 0 0 7.6308 -8.4764 0.0000 O 0 0 7.0224 -9.8505 0.0000 C 0 0 3.9114 -7.5145 0.0000 C 0 0 1.2995 -2.9981 0.0000 N 0 0 6.5191 -5.9785 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 -3.9091 1.5019 0.0000 O 0 0 -3.9091 -1.5019 0.0000 O 0 0 3.9042 -5.9961 0.0000 C 0 0 5.1931 -5.2361 0.0000 C 0 0 2.6003 -3.7467 0.0000 C 0 0 2.6034 -5.2475 0.0000 C 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 7 2 0 5 1 2 0 6 1 1 0 7 5 1 0 8 6 2 0 9 3 1 0 10 16 2 0 11 18 2 0 12 8 1 0 13 10 1 0 14 11 1 0 15 13 1 0 16 22 1 0 17 6 1 0 18 23 1 0 19 2 1 0 20 4 1 0 21 7 1 0 22 25 1 0 23 22 2 0 24 17 1 0 25 24 1 0 26 19 1 0 27 20 1 0 28 21 1 0 12 9 2 0 2 4 1 0 11 10 1 0 14 15 1 0 M END > 73415 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 5.6576 $$$$ SciTegic07090714172D 28 31 0 0 0 0 999 V2000 0.0000 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 N 0 0 1.2964 1.4973 0.0000 N 0 0 3.9106 -7.5064 0.0000 C 0 0 1.2995 -2.9981 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 2.6147 -8.2565 0.0000 C 0 0 5.2080 -8.2534 0.0000 O 0 0 3.9090 -6.0093 0.0000 C 0 0 2.6163 -9.7535 0.0000 O 0 0 1.3173 -7.5095 0.0000 C 0 0 -1.2907 2.9981 0.0000 O 0 0 -3.9091 1.5019 0.0000 O 0 0 2.6034 -5.2475 0.0000 C 0 0 2.6003 -3.7467 0.0000 C 0 0 -3.9091 -1.5019 0.0000 O 0 0 1.3067 -5.9966 0.0000 C 0 0 5.2095 -9.7504 0.0000 C 0 0 3.9137 -10.5005 0.0000 C 0 0 -2.3272 3.6028 0.0000 C 0 0 -3.9072 2.7019 0.0000 C 0 0 -3.9072 -2.7019 0.0000 C 0 0 2 3 2 0 3 1 1 0 4 7 2 0 5 1 1 0 6 1 2 0 7 6 1 0 8 5 2 0 9 3 1 0 10 15 2 0 11 5 1 0 12 8 1 0 13 17 2 0 14 10 1 0 15 20 1 0 16 13 1 0 17 23 1 0 18 2 1 0 19 4 1 0 20 21 1 0 21 11 1 0 22 7 1 0 23 20 2 0 24 14 1 0 25 16 1 0 26 18 1 0 27 19 1 0 28 22 1 0 4 2 1 0 12 9 2 0 13 10 1 0 25 24 1 0 M END > 73427 > J. Med. Chem. 36(24)-1993 3765-3770 > PDE5 > 6.1079 $$$$ SciTegic07090714172D 28 33 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 1.4303 2.4855 0.0000 C 0 0 3.3777 -0.1786 0.0000 C 0 0 -1.8061 2.5600 0.0000 O 0 0 4.1301 -1.4772 0.0000 C 0 0 5.3831 -2.1488 0.0000 C 0 0 4.0836 -2.8980 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 2.8975 2.8012 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 3.3605 4.2280 0.0000 C 0 0 3.9018 1.6869 0.0000 C 0 0 5.3689 1.9995 0.0000 C 0 0 4.8276 4.5405 0.0000 C 0 0 5.8318 3.4263 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 4 1 0 8 3 1 0 9 8 2 0 10 2 2 0 11 1 1 0 12 11 1 0 13 6 1 0 14 9 1 0 15 7 2 0 16 14 1 0 17 16 1 0 18 16 1 0 19 5 1 0 20 13 1 0 11 21 1 1 12 22 1 1 23 21 1 0 24 20 2 0 25 20 1 0 26 25 2 0 27 24 1 0 28 26 1 0 12 10 1 0 23 22 1 0 6 9 1 0 5 7 1 0 17 18 1 0 28 27 2 0 M END > 37998 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 6.3768 $$$$ SciTegic07090714172D 28 31 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 2.1812 2.6271 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -4.9144 0.7421 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -6.2151 1.4892 0.0000 C 0 0 -6.2134 -1.5101 0.0000 C 0 0 4.1200 4.3600 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 -6.2133 -3.0109 0.0000 C 0 0 -4.9211 3.7421 0.0000 C 0 0 -7.2521 -3.6117 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 6.1174 2.1217 0.0000 C 0 0 5.5886 4.6654 0.0000 C 0 0 6.5873 3.5462 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 2 0 6 3 1 0 7 6 1 0 8 4 1 0 9 3 1 0 10 5 1 0 11 4 1 0 12 6 2 0 13 10 2 0 14 11 1 0 15 9 1 0 16 10 1 0 17 13 1 0 18 13 1 0 19 17 1 0 20 14 2 0 21 14 1 0 22 19 1 0 23 16 2 0 24 22 1 0 25 23 1 0 26 21 2 0 27 20 1 0 28 26 1 0 8 9 2 0 5 7 1 0 27 28 2 0 18 25 2 0 M END > 30249 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 6.4559 $$$$ SciTegic07090714172D 28 32 0 0 1 0 999 V2000 3.8000 0.4000 0.0000 N 0 0 1.2600 0.4000 0.0000 C 0 0 1.2600 1.8600 0.0000 C 0 0 3.8000 1.8600 0.0000 C 0 0 1 0 0 0 2.5200 -0.3300 0.0000 C 0 0 1 0 0 0 5.0500 -0.3600 0.0000 C 0 0 0.0000 -0.3300 0.0000 N 0 0 5.0500 2.5700 0.0000 C 0 0 6.3600 1.8600 0.0000 N 0 0 2.5200 2.6000 0.0000 C 0 0 -1.2800 1.8600 0.0000 C 0 0 -1.2800 0.4000 0.0000 C 0 0 6.3600 0.4000 0.0000 C 0 0 2.5149 -1.8307 0.0000 C 0 0 5.0377 -1.5599 0.0000 O 0 0 5.0381 3.7699 0.0000 O 0 0 3.8112 -2.5857 0.0000 C 0 0 1.2132 -2.5761 0.0000 C 0 0 7.3911 2.4739 0.0000 C 0 0 2.5039 -4.8309 0.0000 C 0 0 1.2077 -4.0761 0.0000 C 0 0 3.8057 -4.0857 0.0000 C 0 0 -2.5200 2.6000 0.0000 C 0 0 2.5015 -6.3317 0.0000 O 0 0 -2.5200 -0.3300 0.0000 C 0 0 3.5394 -6.9341 0.0000 C 0 0 -3.7800 1.8600 0.0000 C 0 0 -3.7800 0.4000 0.0000 C 0 0 2 5 1 0 3 2 2 0 4 1 1 0 5 1 1 0 6 1 1 0 7 2 1 0 4 8 1 6 9 13 1 0 10 4 1 0 11 3 1 0 12 7 1 0 13 6 1 0 5 14 1 6 15 6 2 0 16 8 2 0 17 14 2 0 18 14 1 0 19 9 1 0 20 21 1 0 21 18 2 0 22 17 1 0 23 11 2 0 24 20 1 0 25 12 2 0 26 24 1 0 27 23 1 0 28 25 1 0 10 3 1 0 8 9 1 0 20 22 2 0 12 11 1 0 28 27 2 0 M END > 114310 > J. Med. Chem. 46(21)-2003 4533-4542 > PDE5 > 7.3872 $$$$ SciTegic07090714172D 28 33 0 0 1 0 999 V2000 3.8000 0.4000 0.0000 N 0 0 1.2600 0.4000 0.0000 C 0 0 1.2600 1.8600 0.0000 C 0 0 2.5200 -0.3300 0.0000 C 0 0 1 0 0 0 3.8000 1.8600 0.0000 C 0 0 2 0 0 0 0.0000 -0.3300 0.0000 N 0 0 2.5200 2.6000 0.0000 C 0 0 2.5149 -1.8307 0.0000 C 0 0 5.0500 -0.3600 0.0000 C 0 0 5.0500 2.5700 0.0000 C 0 0 -1.2800 1.8600 0.0000 C 0 0 -1.2800 0.4000 0.0000 C 0 0 6.3600 1.8600 0.0000 N 0 0 3.8263 -2.5965 0.0000 C 0 0 3.7969 -4.1002 0.0000 C 0 0 6.3600 0.4000 0.0000 C 0 0 2.4955 -4.8361 0.0000 C 0 0 4.8937 -5.1137 0.0000 O 0 0 2.7988 -6.2984 0.0000 O 0 0 1.2122 -2.5667 0.0000 C 0 0 4.2929 -6.4588 0.0000 C 0 0 5.0377 -1.5599 0.0000 O 0 0 5.0381 3.7699 0.0000 O 0 0 1.1918 -4.0863 0.0000 C 0 0 -2.5200 2.6000 0.0000 C 0 0 -2.5200 -0.3300 0.0000 C 0 0 -3.7800 1.8600 0.0000 C 0 0 -3.7800 0.4000 0.0000 C 0 0 2 4 1 0 3 7 1 0 4 1 1 0 5 1 1 0 6 2 1 0 7 5 1 0 4 8 1 6 9 1 1 0 5 10 1 6 11 3 1 0 12 6 1 0 13 16 1 0 14 8 2 0 15 14 1 0 16 9 1 0 17 24 1 0 18 15 1 0 19 17 1 0 20 8 1 0 21 18 1 0 22 9 2 0 23 10 2 0 24 20 2 0 25 11 2 0 26 12 2 0 27 25 1 0 28 26 1 0 10 13 1 0 3 2 2 0 12 11 1 0 17 15 2 0 19 21 1 0 28 27 2 0 M END > 114308 > J. Med. Chem. 46(21)-2003 4533-4542 > PDE5 > 7.9208 $$$$ SciTegic07090714172D 28 31 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 -1.2919 2.9980 0.0000 N 0 0 -2.6111 0.7486 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -0.5336 5.2819 0.0000 N 0 0 -0.0752 3.8536 0.0000 C 0 0 4.9319 -2.0991 0.0000 N 0 0 -1.2907 -2.9981 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 3.8926 -1.4991 0.0000 C 0 0 -3.8669 -7.5130 0.0000 C 0 0 -2.5022 3.8623 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.0336 5.2872 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 -3.8757 -6.0130 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 -2.5870 -3.7544 0.0000 C 0 0 -4.9025 -8.1191 0.0000 Cl 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 -2.5514 -9.7561 0.0000 O 0 0 -1.5078 -10.3484 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 3 1 0 6 4 1 0 7 6 1 0 8 9 2 0 9 2 1 0 10 13 3 0 11 7 1 0 12 4 2 0 13 20 1 0 14 19 2 0 15 2 1 0 16 6 2 0 17 15 2 0 18 21 2 0 19 22 1 0 20 25 2 0 21 26 1 0 22 23 1 0 23 11 1 0 24 14 1 0 25 12 1 0 26 22 2 0 27 18 1 0 28 27 1 0 7 5 2 0 8 17 1 0 20 16 1 0 18 14 1 0 M END > 73986 > J. Med. Chem. 43(13)-2000 2523-2529 > PDE5 > 8.8239 $$$$ SciTegic07090714172D 29 33 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 -3.9122 1.4966 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -5.2109 0.7445 0.0000 N 0 0 2.5929 0.7486 0.0000 N 0 0 3.8937 7.5122 0.0000 C 0 0 1.2995 2.9981 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 N 0 0 2.5951 8.2529 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 4.9942 8.5216 0.0000 O 0 0 2.9038 9.7140 0.0000 O 0 0 4.3984 9.8689 0.0000 C 0 0 -3.9141 2.6966 0.0000 O 0 0 -2.6111 -0.7486 0.0000 C 0 0 3.9175 6.0083 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -7.8042 -0.7641 0.0000 O 0 0 1.2886 7.5078 0.0000 C 0 0 2.6034 5.2475 0.0000 C 0 0 2.6003 3.7467 0.0000 C 0 0 1.3034 5.9882 0.0000 C 0 0 -6.5125 1.4901 0.0000 C 0 0 -5.2061 -0.7556 0.0000 C 0 0 -6.5027 -1.5098 0.0000 C 0 0 -7.8091 0.7359 0.0000 C 0 0 2 5 1 0 3 1 1 0 4 1 2 0 5 4 1 0 6 2 1 0 7 3 2 0 8 19 2 0 9 3 1 0 10 1 1 0 11 10 1 0 12 22 2 0 13 11 2 0 14 8 1 0 15 12 1 0 16 14 1 0 17 2 2 0 18 20 1 0 19 23 1 0 20 10 2 0 21 28 1 0 22 25 1 0 23 24 1 0 24 9 1 0 25 23 2 0 26 6 1 0 27 6 1 0 28 27 1 0 29 26 1 0 5 18 2 0 13 7 1 0 29 21 1 0 8 12 1 0 15 16 1 0 M END > 17584 > J. Med. Chem. 37(13)-1994 2106-2111 > PDE5 > 5.5686 $$$$ SciTegic07090714172D 29 32 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 -6.3764 7.4686 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -6.2301 5.9885 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -7.8454 7.7721 0.0000 C 0 0 -7.5779 5.3598 0.0000 N 0 0 -8.5879 6.4687 0.0000 N 0 0 -4.9276 5.2429 0.0000 N 0 0 -4.9144 0.7421 0.0000 C 0 0 -3.6204 2.9950 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -4.9211 3.7421 0.0000 C 0 0 -8.3397 8.8655 0.0000 N 0 0 -6.2151 1.4892 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2133 -3.0109 0.0000 C 0 0 -7.2521 -3.6117 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 1 1 0 7 5 1 0 8 6 1 0 9 11 1 0 10 3 1 0 11 16 1 0 12 4 1 0 13 9 2 0 14 11 2 0 15 14 1 0 16 20 1 0 17 12 2 0 18 12 1 0 19 5 2 0 20 18 2 0 21 13 1 0 22 17 1 0 23 6 1 0 24 20 1 0 25 10 1 0 26 17 1 0 27 26 1 0 28 27 1 0 29 28 1 0 8 10 2 0 4 7 1 0 22 24 2 0 13 15 1 0 M END > 30271 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 8.3010 $$$$ SciTegic07090714172D 29 32 0 0 0 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2919 2.9980 0.0000 N 0 0 -2.6111 -0.7486 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2907 -2.9981 0.0000 N 0 0 1.2964 1.4973 0.0000 C 0 0 -3.8669 -7.5130 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 0.0099 3.7437 0.0000 C 0 0 -2.5882 3.7528 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 -3.8757 -6.0130 0.0000 C 0 0 -2.5829 5.2528 0.0000 C 0 0 0.0151 5.2437 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 -2.5870 -3.7544 0.0000 C 0 0 -4.9025 -8.1191 0.0000 Cl 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2813 5.9982 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 3.6321 -1.3486 0.0000 Cl 0 0 -2.5514 -9.7561 0.0000 O 0 0 -1.2770 7.1982 0.0000 O 0 0 -1.5078 -10.3484 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 1 1 0 5 2 1 0 6 3 1 0 7 6 1 0 8 7 1 0 9 3 2 0 10 15 2 0 11 6 2 0 12 4 1 0 13 4 1 0 14 18 2 0 15 20 1 0 16 13 1 0 17 12 1 0 18 25 1 0 19 23 2 0 20 21 1 0 21 8 1 0 22 10 1 0 23 9 1 0 24 16 1 0 25 20 2 0 26 19 1 0 27 14 1 0 28 24 1 0 29 27 1 0 7 5 2 0 24 17 1 0 19 11 1 0 14 10 1 0 M END > 73997 > J. Med. Chem. 43(13)-2000 2523-2529 > PDE5 > 8.3565 $$$$ SciTegic07090714172D 29 32 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 0.2917 0.7475 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 4.0872 0.0320 0.0000 N 0 0 2.1812 2.6271 0.0000 C 0 0 -3.3560 -1.3452 0.0000 O 0 0 -0.9991 2.7132 0.0000 O 0 0 -0.9971 -3.0138 0.0000 C 0 0 -3.6187 1.4919 0.0000 C 0 0 3.6500 2.9355 0.0000 C 0 0 6.5873 3.5462 0.0000 C 0 0 4.8506 -1.2602 0.0000 C 0 0 4.1200 4.3600 0.0000 C 0 0 4.6488 1.8163 0.0000 C 0 0 6.1174 2.1217 0.0000 C 0 0 5.5886 4.6654 0.0000 C 0 0 7.7622 3.7904 0.0000 O 0 0 6.3324 -1.3865 0.0000 C 0 0 4.2401 -2.6164 0.0000 C 0 0 -3.6251 2.6919 0.0000 C 0 0 -2.0337 -3.6184 0.0000 C 0 0 5.3626 -3.6114 0.0000 C 0 0 6.6557 -2.8512 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 1 1 0 5 2 1 0 6 8 1 0 7 3 2 0 8 4 1 0 9 2 1 0 10 7 1 0 11 5 1 0 12 8 2 0 13 9 2 0 14 4 1 0 15 6 1 0 16 11 1 0 17 21 1 0 18 10 1 0 19 16 2 0 20 16 1 0 21 20 2 0 22 19 1 0 23 17 1 0 24 18 1 0 25 18 1 0 26 15 1 0 27 14 1 0 28 25 1 0 29 24 1 0 5 7 1 0 6 9 1 0 29 28 1 0 17 22 2 0 M END > 82500 > Bioorg. Med. Chem. Lett. 12(21)-2002 3149-3152 > PDE5 > 8.8239 $$$$ SciTegic07090714172D 29 34 0 0 0 0 999 V2000 -0.5831 -0.6682 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 0.7168 1.5915 0.0000 N 0 0 -2.0045 1.2999 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 -4.3799 0.0850 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -2.4714 2.7262 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -4.2584 4.6168 0.0000 C 0 0 -3.9241 3.1505 0.0000 C 0 0 -5.2183 1.3232 0.0000 N 0 0 -5.0309 -1.2682 0.0000 N 0 0 -3.1731 5.6450 0.0000 C 0 0 -5.5673 5.3358 0.0000 O 0 0 0.7217 -2.6214 0.0000 O 0 0 -3.8202 6.9908 0.0000 O 0 0 -5.3088 6.7861 0.0000 C 0 0 -1.3801 3.7522 0.0000 C 0 0 -1.7269 5.2318 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 -7.3687 -0.1348 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 -6.7144 1.2150 0.0000 C 0 0 -6.5270 -1.3763 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 2 1 2 0 3 7 1 0 4 2 1 0 5 2 1 0 6 1 1 0 7 1 1 0 8 3 1 0 9 6 1 0 10 5 1 0 11 9 2 0 12 13 2 0 13 10 1 0 14 8 2 0 15 8 1 0 16 22 2 0 17 12 1 0 18 6 2 0 19 16 1 0 20 17 1 0 21 10 2 0 22 21 1 0 23 9 1 0 24 27 1 0 25 11 1 0 26 14 1 0 27 15 2 0 28 23 2 0 29 28 1 0 3 5 1 0 4 11 1 0 24 26 2 0 29 25 2 0 16 12 1 0 20 19 1 0 M END > 105581 > J. Med. Chem. 45(19)-2002 4094-4096 > PDE5 > 8.9208 $$$$ SciTegic07090714172D 30 33 0 0 0 0 999 V2000 0.7168 -1.4214 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -0.5831 -0.6682 0.0000 C 0 0 0.7229 -2.9221 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 0.7521 -5.9219 0.0000 C 0 0 -2.8792 0.0850 0.0000 O 0 0 -0.5541 -5.1845 0.0000 C 0 0 2.0438 -5.1594 0.0000 C 0 0 0.7168 1.5915 0.0000 C 0 0 -0.5686 -3.6845 0.0000 C 0 0 2.0294 -3.6595 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 -2.0045 1.2999 0.0000 C 0 0 -2.3778 -2.2703 0.0000 O 0 0 0.7635 -7.4227 0.0000 O 0 0 -1.8481 -5.9447 0.0000 O 0 0 3.3523 -5.8945 0.0000 O 0 0 5.9025 -1.4212 0.0000 O 0 0 5.9025 1.5913 0.0000 O 0 0 -0.2708 -8.0312 0.0000 C 0 0 4.3848 -5.2831 0.0000 C 0 0 -2.8923 -5.3533 0.0000 C 0 0 5.9009 -2.6212 0.0000 C 0 0 5.9009 2.7913 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 1 1 0 5 2 1 0 6 3 1 0 7 3 1 0 8 2 2 0 9 12 1 0 10 7 1 0 11 14 1 0 12 15 2 0 13 6 2 0 14 4 2 0 15 4 1 0 16 8 1 0 17 5 2 0 18 16 2 0 19 6 1 0 20 7 2 0 21 9 1 0 22 11 1 0 23 12 1 0 24 16 1 0 25 18 1 0 26 21 1 0 27 23 1 0 28 22 1 0 29 24 1 0 30 25 1 0 11 9 2 0 10 19 1 0 13 5 1 0 17 18 1 0 M END > 51247 > J. Med. Chem. 42(7)-1999 1293-1305 > PDE5 > 5.2441 $$$$ SciTegic07090714172D 30 35 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 2.8975 2.8012 0.0000 C 0 0 3.4857 4.1672 0.0000 N 0 0 1.4303 2.4855 0.0000 C 0 0 3.9913 1.7934 0.0000 N 0 0 -1.8061 2.5600 0.0000 O 0 0 3.3777 -0.1786 0.0000 C 0 0 4.9775 4.0111 0.0000 C 0 0 5.2900 2.5440 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 4.1301 -1.4772 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 5.6302 -1.4780 0.0000 C 0 0 3.3795 -2.7760 0.0000 C 0 0 4.1289 -4.0754 0.0000 C 0 0 6.3795 -2.7775 0.0000 C 0 0 5.6289 -4.0761 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 4 1 0 8 3 1 0 9 8 2 0 10 2 2 0 11 1 1 0 12 11 1 0 13 15 1 0 14 13 2 0 15 6 1 0 16 13 1 0 17 7 2 0 18 9 1 0 19 14 1 0 20 16 1 0 21 5 1 0 22 18 1 0 11 23 1 1 12 24 1 1 25 23 1 0 26 22 2 0 27 22 1 0 28 27 2 0 29 26 1 0 30 28 1 0 12 10 1 0 25 24 1 0 6 9 1 0 5 7 1 0 20 19 2 0 30 29 2 0 M END > 38033 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 5.3979 $$$$ SciTegic07090714172D 30 35 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 0.9700 -1.4300 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 -1.8061 2.5600 0.0000 O 0 0 5.6055 3.7385 0.0000 C 0 0 3.3777 -0.1724 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 6.3475 5.0430 0.0000 C 0 0 6.3639 2.4443 0.0000 C 0 0 4.1055 3.7288 0.0000 C 0 0 4.1223 1.1307 0.0000 C 0 0 5.6223 1.1405 0.0000 C 0 0 3.3639 2.4249 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 5.5912 6.3385 0.0000 C 0 0 7.8475 5.0504 0.0000 C 0 0 8.5911 6.3531 0.0000 C 0 0 6.3348 7.6411 0.0000 C 0 0 7.8348 7.6484 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 2 2 0 8 3 1 0 9 4 1 0 10 8 2 0 11 1 1 0 12 11 1 0 13 6 2 0 14 19 2 0 15 10 1 0 16 5 1 0 17 14 1 0 18 21 2 0 19 22 1 0 20 15 1 0 21 20 1 0 22 20 2 0 11 23 1 1 12 24 1 1 25 23 1 0 26 17 2 0 27 17 1 0 28 27 2 0 29 26 1 0 30 28 1 0 12 7 1 0 25 24 1 0 9 10 1 0 5 6 1 0 14 18 1 0 30 29 2 0 M END > 38015 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 7.1805 $$$$ SciTegic07090714172D 30 35 0 0 1 0 999 V2000 3.8000 0.4000 0.0000 N 0 0 1.2600 0.4000 0.0000 C 0 0 1.2600 1.8600 0.0000 C 0 0 3.8000 1.8600 0.0000 C 0 0 1 0 0 0 6.3600 1.8600 0.0000 N 0 0 2.5200 -0.3300 0.0000 C 0 0 1 0 0 0 5.0500 -0.3600 0.0000 C 0 0 0.0000 -0.3300 0.0000 N 0 0 5.0500 2.5700 0.0000 C 0 0 2.5200 2.6000 0.0000 C 0 0 -1.2800 1.8600 0.0000 C 0 0 6.3600 0.4000 0.0000 C 0 0 -1.2800 0.4000 0.0000 C 0 0 7.6551 2.6183 0.0000 C 0 0 2.5149 -1.8307 0.0000 C 0 0 8.9598 1.8764 0.0000 C 0 0 5.0377 -1.5599 0.0000 O 0 0 5.0381 3.7699 0.0000 O 0 0 10.3804 1.9286 0.0000 C 0 0 9.6363 0.6262 0.0000 C 0 0 3.8112 -2.5857 0.0000 C 0 0 1.2132 -2.5761 0.0000 C 0 0 1.2077 -4.0761 0.0000 C 0 0 3.8057 -4.0857 0.0000 C 0 0 2.5039 -4.8309 0.0000 C 0 0 -2.5200 2.6000 0.0000 C 0 0 -2.5200 -0.3300 0.0000 C 0 0 2.4995 -6.0309 0.0000 C 0 0 -3.7800 1.8600 0.0000 C 0 0 -3.7800 0.4000 0.0000 C 0 0 2 6 1 0 3 2 2 0 4 1 1 0 5 12 1 0 6 1 1 0 7 1 1 0 8 2 1 0 4 9 1 6 10 4 1 0 11 3 1 0 12 7 1 0 13 8 1 0 14 5 1 0 6 15 1 6 16 14 1 0 17 7 2 0 18 9 2 0 19 16 1 0 20 16 1 0 21 15 1 0 22 15 2 0 23 22 1 0 24 21 2 0 25 23 2 0 26 11 2 0 27 13 2 0 28 25 1 0 29 26 1 0 30 27 1 0 3 10 1 0 5 9 1 0 13 11 1 0 25 24 1 0 19 20 1 0 30 29 2 0 M END > 114315 > J. Med. Chem. 46(21)-2003 4533-4542 > PDE5 > 7.6383 $$$$ SciTegic07090714172D 30 33 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -6.2301 5.9885 0.0000 C 0 0 -6.2365 7.4894 0.0000 C 0 0 -4.9276 5.2429 0.0000 N 0 0 -7.4520 8.3464 0.0000 S 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9144 0.7421 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -4.9211 3.7421 0.0000 C 0 0 -5.0249 8.3519 0.0000 C 0 0 -7.2669 5.3844 0.0000 O 0 0 -6.9916 9.7741 0.0000 C 0 0 -5.4917 9.7774 0.0000 C 0 0 -6.2151 1.4892 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2132 -3.0110 0.0000 C 0 0 -7.2520 -3.6117 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 1 1 0 7 5 1 0 8 6 1 0 9 3 1 0 10 4 1 0 11 13 1 0 12 11 1 0 13 18 1 0 14 12 1 0 15 10 1 0 16 10 2 0 17 5 2 0 18 15 2 0 19 12 2 0 20 11 2 0 21 14 1 0 22 19 1 0 23 16 1 0 24 6 1 0 25 23 2 0 26 9 1 0 27 16 1 0 28 27 1 0 29 28 1 0 30 29 1 0 8 9 2 0 4 7 1 0 25 18 1 0 22 21 2 0 M END > 30262 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 8.8239 $$$$ SciTegic07090714172D 31 35 0 0 0 0 999 V2000 0.2917 -0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 N 0 0 -2.3155 0.7475 0.0000 N 0 0 0.2917 0.7475 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 1.7138 -1.2033 0.0000 N 0 0 4.8208 1.3475 0.0000 S 0 0 2.5889 0.0182 0.0000 C 0 0 4.0872 0.0382 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 -0.9971 -3.0138 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 6.3215 1.3677 0.0000 C 0 0 4.2072 2.3788 0.0000 O 0 0 3.6210 1.3319 0.0000 O 0 0 -3.3560 -1.3452 0.0000 O 0 0 -4.9153 0.7255 0.0000 C 0 0 -2.2935 -3.7700 0.0000 C 0 0 -0.9991 2.7132 0.0000 O 0 0 -6.3365 0.7566 0.0000 C 0 0 -2.9615 -5.0248 0.0000 C 0 0 -3.7145 -3.7275 0.0000 C 0 0 -5.5732 -0.5347 0.0000 C 0 0 7.0890 0.0789 0.0000 C 0 0 7.0540 2.6768 0.0000 C 0 0 9.3213 1.4081 0.0000 C 0 0 8.5538 2.6970 0.0000 C 0 0 8.5888 0.0991 0.0000 C 0 0 10.8220 1.4253 0.0000 O 0 0 11.4345 0.3933 0.0000 C 0 0 2 1 1 0 3 6 1 0 4 1 2 0 5 2 1 0 6 4 1 0 7 1 1 0 8 10 1 0 9 7 2 0 10 9 1 0 11 4 1 0 12 2 1 0 13 3 1 0 14 8 1 0 15 8 2 0 16 8 2 0 17 5 2 0 18 13 1 0 19 12 1 0 20 6 2 0 21 18 1 0 22 19 1 0 23 19 1 0 24 18 1 0 25 14 2 0 26 14 1 0 27 28 1 0 28 26 2 0 29 25 1 0 30 27 1 0 31 30 1 0 9 11 1 0 3 5 1 0 23 22 1 0 21 24 1 0 29 27 2 0 M END > 15223 > J. Med. Chem. 37(4)-1994 476-485 > PDE5A > 4.1675 $$$$ SciTegic07090714172D 31 34 0 0 0 0 999 V2000 -3.8831 6.0052 0.0000 N 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -2.5853 5.2515 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -5.1853 5.2606 0.0000 C 0 0 -1.2919 2.9980 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5891 3.7515 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2844 5.9982 0.0000 N 0 0 -3.8770 7.5053 0.0000 C 0 0 -6.4813 6.0160 0.0000 C 0 0 -5.1903 4.0607 0.0000 O 0 0 -5.1729 8.2606 0.0000 C 0 0 -6.4751 7.5160 0.0000 C 0 0 0.0127 5.2449 0.0000 C 0 0 3.8911 1.5017 0.0000 O 0 0 3.8911 -1.5017 0.0000 O 0 0 0.0089 3.7449 0.0000 C 0 0 -3.9122 1.4966 0.0000 C 0 0 -3.9091 -1.5019 0.0000 C 0 0 -4.9506 0.8952 0.0000 O 0 0 -3.9072 -2.7019 0.0000 O 0 0 3.8894 2.7017 0.0000 C 0 0 3.8894 -2.7017 0.0000 C 0 0 2 3 1 0 3 7 1 0 4 1 1 0 5 2 1 0 6 1 1 0 7 10 1 0 8 3 2 0 9 2 2 0 10 4 2 0 11 8 1 0 12 11 2 0 13 9 1 0 14 5 2 0 15 13 2 0 16 4 1 0 17 1 1 0 18 6 1 0 19 6 2 0 20 17 2 0 21 20 1 0 22 16 2 0 23 13 1 0 24 15 1 0 25 22 1 0 26 8 1 0 27 11 1 0 28 26 1 0 29 27 1 0 30 23 1 0 31 24 1 0 18 21 2 0 7 25 2 0 5 12 1 0 14 15 1 0 M END > 50919 > J. Med. Chem. 42(6)-1999 1088-1099 > PDE5 > 4.3979 $$$$ SciTegic07090714172D 31 36 0 0 0 0 999 V2000 -4.1791 5.5446 0.0000 C 0 0 -2.7175 5.2300 0.0000 C 0 0 -4.6553 6.9712 0.0000 N 0 0 -2.1689 7.7788 0.0000 N 0 0 -4.9239 4.2502 0.0000 N 0 0 -3.6305 8.0934 0.0000 C 0 0 -2.5870 3.7544 0.0000 N 0 0 -1.6965 6.3344 0.0000 C 0 0 -3.9138 3.1377 0.0000 C 0 0 -1.2907 2.9981 0.0000 C 0 0 -6.1234 7.2814 0.0000 C 0 0 -1.1670 8.8962 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 -3.9958 9.2364 0.0000 O 0 0 -0.5242 6.0783 0.0000 O 0 0 -6.5899 8.7079 0.0000 C 0 0 0.3019 8.5883 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 1.6387 9.0717 0.0000 C 0 0 -7.6761 9.6250 0.0000 C 0 0 -6.2494 10.0881 0.0000 C 0 0 1.3278 7.6043 0.0000 C 0 0 -4.1514 1.9614 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 2 1 2 0 3 1 1 0 4 6 1 0 5 1 1 0 6 3 1 0 7 2 1 0 8 2 1 0 9 5 2 0 10 7 1 0 11 3 1 0 12 4 1 0 13 10 1 0 14 6 2 0 15 8 2 0 16 11 1 0 17 12 1 0 18 13 2 0 19 17 1 0 20 16 1 0 21 16 1 0 22 17 1 0 23 9 1 0 24 18 1 0 25 13 1 0 26 25 2 0 27 18 1 0 28 26 1 0 29 24 1 0 30 27 2 0 31 30 1 0 9 7 1 0 8 4 1 0 21 20 1 0 19 22 1 0 24 28 2 0 29 31 2 0 M END > 15213 > J. Med. Chem. 37(4)-1994 476-485 > PDE5A > 5.0088 $$$$ SciTegic07090714172D 31 36 0 0 1 0 999 V2000 -1.8100 -1.7200 0.0000 N 0 0 -3.1600 -0.9600 0.0000 C 0 0 -0.4800 -0.9600 0.0000 C 0 0 -0.4800 0.5900 0.0000 C 0 0 -3.1600 0.5900 0.0000 N 0 0 0.9700 1.0600 0.0000 N 0 0 -1.8100 1.3600 0.0000 C 0 0 0.9700 -1.4300 0.0000 N 0 0 1.8800 -0.1800 0.0000 C 0 0 -4.3000 -1.9800 0.0000 N 0 0 -2.1400 -3.2100 0.0000 C 0 0 2 0 0 0 -3.6700 -3.3900 0.0000 C 0 0 1 0 0 0 1.4303 2.4855 0.0000 C 0 0 -1.8061 2.5600 0.0000 O 0 0 3.3777 -0.1786 0.0000 C 0 0 4.8276 4.5405 0.0000 N 0 0 2.8975 2.8012 0.0000 C 0 0 -4.1977 1.1927 0.0000 C 0 0 4.1301 -1.4772 0.0000 C 0 0 -1.5100 -4.6300 0.0000 C 0 0 3.3605 4.2280 0.0000 C 0 0 -3.9800 -4.8800 0.0000 C 0 0 -2.6500 -5.6600 0.0000 C 0 0 5.8318 3.4263 0.0000 C 0 0 3.9018 1.6869 0.0000 C 0 0 5.6302 -1.4780 0.0000 C 0 0 3.3795 -2.7760 0.0000 C 0 0 5.3689 1.9995 0.0000 C 0 0 6.3795 -2.7775 0.0000 C 0 0 4.1289 -4.0754 0.0000 C 0 0 5.6289 -4.0761 0.0000 C 0 0 2 1 1 0 3 1 1 0 4 3 2 0 5 2 1 0 6 4 1 0 7 4 1 0 8 3 1 0 9 8 2 0 10 2 2 0 11 1 1 0 12 11 1 0 13 6 1 0 14 7 2 0 15 9 1 0 16 21 2 0 17 13 1 0 18 5 1 0 19 15 1 0 11 20 1 1 21 17 1 0 12 22 1 1 23 20 1 0 24 28 2 0 25 17 2 0 26 19 2 0 27 19 1 0 28 25 1 0 29 26 1 0 30 27 2 0 31 30 1 0 12 10 1 0 23 22 1 0 6 9 1 0 5 7 1 0 31 29 2 0 24 16 1 0 M END > 38032 > J. Med. Chem. 40(14)-1997 2196-2210 > PDE5 > 5.3665 $$$$ SciTegic07090714172D 31 34 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9211 3.7421 0.0000 C 0 0 -4.9276 5.2429 0.0000 C 0 0 -6.2365 7.4894 0.0000 N 0 0 -4.9144 0.7421 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -6.2301 5.9885 0.0000 C 0 0 -3.8907 5.8470 0.0000 O 0 0 -6.2185 2.9892 0.0000 C 0 0 -6.2151 1.4892 0.0000 C 0 0 -6.2433 10.4894 0.0000 O 0 0 2.0825 2.3453 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -7.5372 8.2365 0.0000 C 0 0 -4.9392 8.2424 0.0000 C 0 0 -4.9426 9.7424 0.0000 C 0 0 -7.5406 9.7365 0.0000 C 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2132 -3.0110 0.0000 C 0 0 -7.2520 -3.6117 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 1 1 0 7 5 1 0 8 6 1 0 9 3 1 0 10 4 1 0 11 10 1 0 12 11 2 0 13 12 1 0 14 17 1 0 15 10 2 0 16 5 2 0 17 13 1 0 18 13 2 0 19 20 2 0 20 15 1 0 21 27 1 0 22 6 1 0 23 9 1 0 24 15 1 0 25 14 1 0 26 14 1 0 27 26 1 0 28 25 1 0 29 24 1 0 30 29 1 0 31 30 1 0 8 9 2 0 4 7 1 0 19 12 1 0 28 21 1 0 M END > 30250 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 6.5229 $$$$ SciTegic07090714172D 31 34 0 0 1 0 999 V2000 -1.2964 1.4973 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -2.6111 -0.7486 0.0000 N 0 0 -1.2964 -1.4973 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 4.9319 -2.0991 0.0000 N 0 0 -1.2907 -2.9981 0.0000 N 0 0 3.8926 -1.4991 0.0000 C 0 0 -3.8669 -7.5130 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 -3.8757 -6.0130 0.0000 C 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 2 0 0 0 -2.5870 -3.7544 0.0000 C 0 0 -4.9025 -8.1191 0.0000 Cl 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 -5.1815 5.2608 0.0000 C 0 0 1 0 0 0 -2.5514 -9.7561 0.0000 O 0 0 -2.5835 5.2544 0.0000 C 0 0 -3.8880 3.0076 0.0000 C 0 0 -5.1852 3.7608 0.0000 C 0 0 -3.8807 6.0076 0.0000 C 0 0 -6.2193 5.8633 0.0000 O 0 0 -1.5078 -10.3484 0.0000 C 0 0 2 1 2 0 3 4 1 0 4 1 1 0 5 2 1 0 6 3 1 0 7 1 1 0 8 10 3 0 9 6 1 0 10 16 1 0 11 15 2 0 12 4 2 0 13 3 2 0 14 17 2 0 15 18 1 0 16 22 2 0 17 23 1 0 18 20 1 0 19 7 1 1 20 9 1 0 21 11 1 0 22 12 1 0 23 18 2 0 24 28 1 0 25 14 1 0 26 19 1 0 27 19 1 0 28 27 1 0 29 26 1 0 24 30 1 6 31 25 1 0 6 5 2 0 24 29 1 0 16 13 1 0 11 14 1 0 M END > 73992 > J. Med. Chem. 43(13)-2000 2523-2529 > PDE5 > 7.9208 $$$$ SciTegic07090714172D 31 35 0 0 0 0 999 V2000 -2.6111 0.7486 0.0000 N 0 0 -2.6111 -0.7486 0.0000 C 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 N 0 0 -3.9086 -1.5029 0.0000 N 0 0 0.0000 -0.7486 0.0000 C 0 0 -7.8065 -3.7531 0.0000 C 0 0 -1.2907 2.9981 0.0000 N 0 0 -3.8580 7.5275 0.0000 C 0 0 -2.5550 8.2605 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -4.9525 8.5435 0.0000 O 0 0 -2.8550 9.7234 0.0000 O 0 0 -3.9097 -3.0028 0.0000 C 0 0 -5.2071 -0.7519 0.0000 C 0 0 -4.3487 9.8872 0.0000 C 0 0 -6.5078 -3.0010 0.0000 C 0 0 -3.8908 6.0238 0.0000 C 0 0 -7.8056 -4.9531 0.0000 O 0 0 1.2964 -1.4973 0.0000 C 0 0 -6.5067 -1.5010 0.0000 C 0 0 -5.2093 -3.7519 0.0000 C 0 0 -1.2530 7.5077 0.0000 C 0 0 2.5929 0.7486 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -8.8464 -3.1542 0.0000 O 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2768 5.9882 0.0000 C 0 0 3.6321 1.3486 0.0000 Cl 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 2 2 0 6 2 1 0 7 4 1 0 8 18 1 0 9 3 1 0 10 19 2 0 11 24 2 0 12 4 2 0 13 10 1 0 14 11 1 0 15 6 1 0 16 6 1 0 17 13 1 0 18 22 1 0 19 26 1 0 20 8 2 0 21 7 2 0 22 16 1 0 23 15 1 0 24 30 1 0 25 12 1 0 26 27 1 0 27 9 1 0 28 8 1 0 29 25 2 0 30 26 2 0 31 25 1 0 7 5 1 0 23 18 1 0 21 29 1 0 10 11 1 0 14 17 1 0 M END > 46155 > J. Med. Chem. 41(18)-1998 3367-3372 > PDE5 > 8.0655 $$$$ SciTegic07090714172D 31 34 0 0 0 0 999 V2000 0.0000 0.7486 0.0000 C 0 0 -2.6111 0.7486 0.0000 N 0 0 -2.6111 -0.7486 0.0000 N 0 0 -1.2964 1.4973 0.0000 C 0 0 0.0000 -0.7486 0.0000 C 0 0 -1.2964 -1.4973 0.0000 C 0 0 4.9319 2.0991 0.0000 N 0 0 -1.2907 -2.9981 0.0000 N 0 0 -1.2907 2.9981 0.0000 N 0 0 3.8926 1.4991 0.0000 C 0 0 -3.8669 7.5130 0.0000 C 0 0 1.2964 -1.4973 0.0000 C 0 0 1.2964 1.4973 0.0000 C 0 0 -2.5634 8.2553 0.0000 C 0 0 -3.8757 6.0130 0.0000 C 0 0 -3.8669 -7.5130 0.0000 N 0 0 2.5929 0.7486 0.0000 C 0 0 -1.2688 7.4976 0.0000 C 0 0 -2.5812 -5.2552 0.0000 C 0 0 -2.5870 -3.7544 0.0000 C 0 0 -2.5812 5.2552 0.0000 C 0 0 -2.5870 3.7544 0.0000 C 0 0 -4.9025 8.1191 0.0000 Cl 0 0 2.5929 -0.7486 0.0000 C 0 0 -1.2777 5.9976 0.0000 C 0 0 -2.5514 9.7561 0.0000 O 0 0 -3.8757 -6.0130 0.0000 C 0 0 -2.5634 -8.2553 0.0000 C 0 0 -1.2777 -5.9976 0.0000 C 0 0 -1.5078 10.3484 0.0000 C 0 0 -1.2688 -7.4976 0.0000 C 0 0 2 4 2 0 3 6 2 0 4 1 1 0 5 1 1 0 6 5 1 0 7 10 3 0 8 6 1 0 9 4 1 0 10 17 1 0 11 15 2 0 12 5 2 0 13 1 2 0 14 18 2 0 15 21 1 0 16 27 1 0 17 13 1 0 18 25 1 0 19 20 1 0 20 8 1 0 21 22 1 0 22 9 1 0 23 11 1 0 24 17 2 0 25 21 2 0 26 14 1 0 27 19 2 0 28 31 1 0 29 19 1 0 30 26 1 0 31 29 2 0 24 12 1 0 2 3 1 0 11 14 1 0 28 16 2 0 M END > 73988 > J. Med. Chem. 43(13)-2000 2523-2529 > PDE5 > 8.1675 $$$$ SciTegic07090714172D 31 36 0 0 0 0 999 V2000 -0.5831 -0.6682 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 0.7168 1.5915 0.0000 N 0 0 -2.0045 1.2999 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -4.3776 0.0819 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -2.4714 2.7262 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -5.1261 -1.2189 0.0000 C 0 0 -4.2584 4.6168 0.0000 C 0 0 -3.9241 3.1505 0.0000 C 0 0 -3.1731 5.6450 0.0000 C 0 0 -5.5673 5.3358 0.0000 O 0 0 0.7217 -2.6214 0.0000 O 0 0 -4.9794 1.1201 0.0000 O 0 0 -3.8202 6.9908 0.0000 O 0 0 -5.3088 6.7861 0.0000 C 0 0 -1.3801 3.7522 0.0000 C 0 0 -7.3716 -2.5258 0.0000 N 0 0 -1.7269 5.2318 0.0000 C 0 0 -6.6261 -1.2242 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 -4.3716 -2.5154 0.0000 C 0 0 -6.6171 -3.8223 0.0000 C 0 0 -5.1171 -3.8171 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 2 1 2 0 3 8 1 0 4 2 1 0 5 2 1 0 6 1 1 0 7 3 1 0 8 1 1 0 9 6 1 0 10 5 1 0 11 9 1 0 12 7 1 0 13 14 1 0 14 10 2 0 15 23 1 0 16 13 1 0 17 6 2 0 18 7 2 0 19 15 1 0 20 16 1 0 21 10 1 0 22 24 1 0 23 21 2 0 24 12 2 0 25 9 2 0 26 11 2 0 27 12 1 0 28 29 1 0 29 27 2 0 30 25 1 0 31 30 2 0 3 5 1 0 11 4 1 0 26 31 1 0 13 15 2 0 28 22 2 0 19 20 1 0 M END > 108300 > J. Med. Chem. 46(3)-2003 441-444 > PDE5 > 8.4789 $$$$ SciTegic07090714172D 31 34 0 0 1 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 0.2917 -0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 2.5889 0.0182 0.0000 N 0 0 -1.0028 -1.5132 0.0000 N 0 0 1.7138 -1.2033 0.0000 N 0 0 1.7138 1.2033 0.0000 C 0 0 -3.6217 1.4865 0.0000 C 0 0 -2.3155 -0.7475 0.0000 C 0 0 -0.9971 3.0138 0.0000 N 0 0 -4.9153 0.7255 0.0000 N 0 0 -3.5736 7.5284 0.0000 C 0 0 -2.2702 8.2708 0.0000 C 0 0 -3.6319 2.6865 0.0000 O 0 0 -3.5824 6.0284 0.0000 C 0 0 -7.6378 -0.7789 0.0000 O 0 0 -0.9756 7.5132 0.0000 C 0 0 -2.2935 3.7700 0.0000 C 0 0 -2.2878 5.2708 0.0000 C 0 0 -4.6093 8.1345 0.0000 Cl 0 0 -6.2216 1.4644 0.0000 C 0 0 -0.9844 6.0132 0.0000 C 0 0 -7.5151 0.7033 0.0000 C 0 0 2 0 0 0 2.1855 -2.6254 0.0000 C 0 0 -2.2584 9.7716 0.0000 O 0 0 -9.1017 -1.1058 0.0000 C 0 0 -1.2148 10.3640 0.0000 C 0 0 -8.8728 1.3104 0.0000 C 0 0 3.3606 -2.8684 0.0000 C 0 0 -9.8650 0.1855 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 3 1 0 5 8 2 0 6 2 2 0 7 2 1 0 8 1 1 0 9 4 1 0 10 4 2 0 11 3 1 0 12 9 1 0 13 16 2 0 14 18 2 0 15 9 2 0 16 20 1 0 17 24 1 0 18 23 1 0 19 11 1 0 20 19 1 0 21 13 1 0 22 12 1 0 23 20 2 0 24 22 1 1 25 7 1 0 26 14 1 0 27 17 1 0 28 26 1 0 29 24 1 0 30 25 1 0 31 29 1 0 7 5 1 0 10 6 1 0 14 13 1 0 27 31 1 0 M END > 85935 > J. Med. Chem. 45(7)-2001 1025-1027 > PDE5 > 8.7447 $$$$ SciTegic07090714172D 32 37 0 0 1 0 999 V2000 3.8000 0.4000 0.0000 N 0 0 1.2600 0.4000 0.0000 C 0 0 1.2600 1.8600 0.0000 C 0 0 3.8000 1.8600 0.0000 C 0 0 1 0 0 0 5.0500 2.5700 0.0000 C 0 0 6.3600 1.8600 0.0000 N 0 0 5.0500 -0.3600 0.0000 C 0 0 2.5200 -0.3300 0.0000 C 0 0 1 0 0 0 0.0000 -0.3300 0.0000 N 0 0 6.3600 0.4000 0.0000 C 0 0 2.5200 2.6000 0.0000 C 0 0 -1.2800 1.8600 0.0000 C 0 0 -1.2800 0.4000 0.0000 C 0 0 2.5149 -1.8307 0.0000 C 0 0 5.0381 3.7699 0.0000 O 0 0 5.0377 -1.5599 0.0000 O 0 0 7.6495 2.6278 0.0000 C 0 0 3.8112 -2.5857 0.0000 C 0 0 1.2132 -2.5761 0.0000 C 0 0 2.5039 -4.8309 0.0000 C 0 0 1.2077 -4.0761 0.0000 C 0 0 3.8057 -4.0857 0.0000 C 0 0 -2.5200 2.6000 0.0000 C 0 0 2.5015 -6.3317 0.0000 O 0 0 -2.5200 -0.3300 0.0000 C 0 0 7.7838 4.1084 0.0000 C 0 0 9.0021 2.0092 0.0000 C 0 0 3.5394 -6.9341 0.0000 C 0 0 -3.7800 1.8600 0.0000 C 0 0 -3.7800 0.4000 0.0000 C 0 0 9.2503 4.4235 0.0000 C 0 0 10.0033 3.1262 0.0000 C 0 0 2 8 1 0 3 2 2 0 4 1 1 0 4 5 1 6 6 10 1 0 7 1 1 0 8 1 1 0 9 2 1 0 10 7 1 0 11 4 1 0 12 3 1 0 13 9 1 0 8 14 1 6 15 5 2 0 16 7 2 0 17 6 1 0 18 14 2 0 19 14 1 0 20 21 1 0 21 19 2 0 22 18 1 0 23 12 2 0 24 20 1 0 25 13 2 0 26 17 1 0 27 17 1 0 28 24 1 0 29 23 1 0 30 25 1 0 31 26 1 0 32 27 1 0 3 11 1 0 5 6 1 0 20 22 2 0 13 12 1 0 30 29 2 0 31 32 1 0 M END > 114323 > J. Med. Chem. 46(21)-2003 4533-4542 > PDE5 > 7.7696 $$$$ SciTegic07090714172D 32 37 0 0 0 0 999 V2000 -0.5831 -0.6682 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 0.7168 1.5915 0.0000 N 0 0 -2.0045 1.2999 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 -4.3776 0.0819 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -2.4714 2.7262 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -4.2584 4.6168 0.0000 C 0 0 -3.9241 3.1505 0.0000 C 0 0 -3.1731 5.6450 0.0000 C 0 0 -5.5673 5.3358 0.0000 O 0 0 -5.1261 -1.2189 0.0000 C 0 0 0.7217 -2.6214 0.0000 O 0 0 -3.8202 6.9908 0.0000 O 0 0 -4.9794 1.1201 0.0000 O 0 0 -5.3088 6.7861 0.0000 C 0 0 -1.3801 3.7522 0.0000 C 0 0 -1.7269 5.2318 0.0000 C 0 0 -6.6269 -1.2220 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 -7.3770 -2.5211 0.0000 C 0 0 -7.3771 0.0770 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 -8.8771 0.0769 0.0000 C 0 0 -8.8770 -2.5211 0.0000 C 0 0 -9.6270 -1.2221 0.0000 C 0 0 2 1 2 0 3 7 1 0 4 2 1 0 5 2 1 0 6 1 1 0 7 1 1 0 8 3 1 0 9 6 1 0 10 5 1 0 11 9 1 0 12 13 2 0 13 10 1 0 14 22 2 0 15 12 1 0 16 8 1 0 17 6 2 0 18 14 1 0 19 8 2 0 20 15 1 0 21 10 2 0 22 21 1 0 23 16 1 0 24 9 2 0 25 11 2 0 26 23 2 0 27 23 1 0 28 24 1 0 29 28 2 0 30 27 2 0 31 26 1 0 32 30 1 0 3 5 1 0 11 4 1 0 25 29 1 0 14 12 1 0 20 18 1 0 32 31 2 0 M END > 126740 > J. Med. Chem. 47(3)-2004 656-662 > PDE5 > 7.9031 $$$$ SciTegic07090714172D 33 38 0 0 1 0 999 V2000 6.3672 3.0792 0.0000 N 0 0 6.4368 1.5831 0.0000 C 0 0 5.0451 1.0438 0.0000 N 0 0 2.9748 -0.5567 0.0000 C 0 0 2.0354 0.6089 0.0000 C 0 0 4.8885 3.5141 0.0000 C 0 0 4.0708 2.2442 0.0000 C 0 0 1 0 0 0 4.4536 -0.3479 0.0000 C 0 0 2 0 0 0 2.1572 -1.8093 0.0000 N 0 0 2.5921 1.9832 0.0000 C 0 0 0.6437 0.0870 0.0000 C 0 0 0.6959 -1.3917 0.0000 C 0 0 7.5493 3.9997 0.0000 C 0 0 7.4423 0.9282 0.0000 O 0 0 5.3673 -1.5385 0.0000 C 0 0 8.5283 6.4084 0.0000 N 0 0 4.4698 4.6387 0.0000 O 0 0 7.3440 5.4865 0.0000 C 0 0 6.8540 -1.3354 0.0000 C 0 0 4.8007 -2.9273 0.0000 C 0 0 7.2060 -3.9095 0.0000 C 0 0 5.7198 -4.1127 0.0000 C 0 0 7.7731 -2.5208 0.0000 C 0 0 -0.6611 0.8176 0.0000 C 0 0 8.1280 -5.0937 0.0000 O 0 0 -0.5741 -2.1572 0.0000 C 0 0 8.4644 7.8943 0.0000 C 0 0 9.9513 5.9760 0.0000 C 0 0 9.3167 -4.9294 0.0000 C 0 0 -1.9484 0.0348 0.0000 C 0 0 10.7949 7.2164 0.0000 C 0 0 9.8759 8.4019 0.0000 C 0 0 -1.8788 -1.4265 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 8 1 0 5 10 1 0 6 1 1 0 7 6 1 6 8 3 1 0 9 4 1 0 10 7 1 0 11 5 1 0 12 11 1 0 13 1 1 0 14 2 2 0 8 15 1 1 16 18 1 0 17 6 2 0 18 13 1 0 19 15 1 0 20 15 2 0 21 22 2 0 22 20 1 0 23 19 2 0 24 11 2 0 25 21 1 0 26 12 2 0 27 16 1 0 28 16 1 0 29 25 1 0 30 24 1 0 31 28 1 0 32 27 1 0 33 30 2 0 3 7 1 0 5 4 2 0 31 32 1 0 9 12 1 0 21 23 1 0 33 26 1 0 M END > 114289 > J. Med. Chem. 46(21)-2003 4525-4532 > PDE5 > 7.0000 $$$$ SciTegic07090714172D 33 38 0 0 1 0 999 V2000 6.3672 3.0792 0.0000 N 0 0 6.4368 1.5831 0.0000 C 0 0 5.0451 1.0438 0.0000 N 0 0 2.9748 -0.5567 0.0000 C 0 0 4.8885 3.5141 0.0000 C 0 0 2.0354 0.6089 0.0000 C 0 0 4.0708 2.2442 0.0000 C 0 0 1 0 0 0 4.4536 -0.3479 0.0000 C 0 0 2 0 0 0 2.1572 -1.8093 0.0000 N 0 0 2.5921 1.9832 0.0000 C 0 0 0.6437 0.0870 0.0000 C 0 0 0.6959 -1.3917 0.0000 C 0 0 7.5493 3.9997 0.0000 C 0 0 7.4423 0.9282 0.0000 O 0 0 5.3673 -1.5385 0.0000 C 0 0 4.4698 4.6387 0.0000 O 0 0 8.3178 7.8952 0.0000 N 0 0 7.3440 5.4865 0.0000 C 0 0 6.8540 -1.3354 0.0000 C 0 0 4.8007 -2.9273 0.0000 C 0 0 7.2060 -3.9095 0.0000 C 0 0 5.7198 -4.1127 0.0000 C 0 0 7.7731 -2.5208 0.0000 C 0 0 8.5262 6.4097 0.0000 C 0 0 -0.6611 0.8176 0.0000 C 0 0 8.1280 -5.0937 0.0000 O 0 0 -0.5741 -2.1572 0.0000 C 0 0 6.9272 8.4575 0.0000 C 0 0 5.9533 6.0488 0.0000 C 0 0 9.3167 -4.9294 0.0000 C 0 0 5.7449 7.5343 0.0000 C 0 0 -1.9484 0.0348 0.0000 C 0 0 -1.8788 -1.4265 0.0000 C 0 0 2 1 1 0 3 2 1 0 4 8 1 0 5 1 1 0 6 10 1 0 7 5 1 6 8 3 1 0 9 4 1 0 10 7 1 0 11 6 1 0 12 11 1 0 13 1 1 0 14 2 2 0 8 15 1 1 16 5 2 0 17 24 1 0 18 13 1 0 19 15 1 0 20 15 2 0 21 22 2 0 22 20 1 0 23 19 2 0 24 18 2 0 25 11 2 0 26 21 1 0 27 12 2 0 28 31 1 0 29 18 1 0 30 26 1 0 31 29 2 0 32 25 1 0 33 32 2 0 3 7 1 0 6 4 2 0 28 17 2 0 9 12 1 0 21 23 1 0 33 27 1 0 M END > 114287 > J. Med. Chem. 46(21)-2003 4525-4532 > PDE5 > 7.6990 $$$$ SciTegic07090714172D 33 37 0 0 0 0 999 V2000 0.2917 0.7475 0.0000 C 0 0 -1.0028 1.5132 0.0000 N 0 0 0.2917 -0.7475 0.0000 C 0 0 -2.3155 0.7475 0.0000 C 0 0 -1.0028 -1.5132 0.0000 C 0 0 -3.7143 6.1073 0.0000 N 0 0 1.7138 1.2033 0.0000 N 0 0 -2.3155 -0.7475 0.0000 N 0 0 2.5889 0.0182 0.0000 N 0 0 1.7138 -1.2033 0.0000 C 0 0 -3.6168 1.4950 0.0000 C 0 0 -4.9245 5.2428 0.0000 C 0 0 -4.1832 7.5321 0.0000 C 0 0 -6.1413 6.0980 0.0000 N 0 0 -5.6832 7.5264 0.0000 N 0 0 -3.6204 2.9950 0.0000 C 0 0 -4.9211 3.7421 0.0000 C 0 0 -4.9144 0.7421 0.0000 C 0 0 -0.9991 -2.7132 0.0000 O 0 0 -3.3058 8.7496 0.0000 C 0 0 -6.2185 2.9892 0.0000 C 0 0 -6.2151 1.4892 0.0000 C 0 0 2.0825 2.3453 0.0000 C 0 0 2.0907 -2.3426 0.0000 C 0 0 -4.9142 -0.7587 0.0000 O 0 0 -3.8156 10.1550 0.0000 C 0 0 -1.8282 8.4817 0.0000 C 0 0 -6.2134 -1.5101 0.0000 C 0 0 -6.2132 -3.0110 0.0000 C 0 0 -7.2520 -3.6117 0.0000 C 0 0 -2.8495 11.3025 0.0000 C 0 0 -0.8621 9.6292 0.0000 C 0 0 -1.3727 11.0396 0.0000 C 0 0 2 1 1 0 3 1 2 0 4 2 2 0 5 3 1 0 6 12 1 0 7 1 1 0 8 5 1 0 9 7 1 0 10 3 1 0 11 4 1 0 12 17 1 0 13 6 2 0 14 12 2 0 15 14 1 0 16 11 1 0 17 16 2 0 18 11 2 0 19 5 2 0 20 13 1 0 21 22 2 0 22 18 1 0 23 7 1 0 24 10 1 0 25 18 1 0 26 20 2 0 27 20 1 0 28 25 1 0 29 28 1 0 30 29 1 0 31 26 1 0 32 27 2 0 33 32 1 0 9 10 2 0 8 4 1 0 21 17 1 0 13 15 1 0 31 33 2 0 M END > 30272 > J. Med. Chem. 39(8)-1996 1635-1644 > PDE5 > 7.6990 $$$$ SciTegic07090714172D 33 38 0 0 0 0 999 V2000 -0.5831 -0.6682 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 0.7168 1.5915 0.0000 N 0 0 -2.0045 1.2999 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -2.4714 2.7262 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -4.3776 0.0819 0.0000 C 0 0 -4.2584 4.6168 0.0000 C 0 0 -3.9241 3.1505 0.0000 C 0 0 -3.1731 5.6450 0.0000 C 0 0 -5.5673 5.3358 0.0000 O 0 0 0.7217 -2.6214 0.0000 O 0 0 -3.8202 6.9908 0.0000 O 0 0 -5.3088 6.7861 0.0000 C 0 0 -1.3801 3.7522 0.0000 C 0 0 -4.9794 1.1201 0.0000 O 0 0 -5.1261 -1.2189 0.0000 C 0 0 -1.7269 5.2318 0.0000 C 0 0 -6.6269 -1.2220 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 -7.3755 -2.5229 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 -8.8755 -2.5282 0.0000 C 0 0 -6.6210 -3.8194 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 -7.3665 -5.1210 0.0000 C 0 0 -9.6210 -3.8298 0.0000 C 0 0 -8.8665 -5.1262 0.0000 C 0 0 2 1 2 0 3 7 1 0 4 2 1 0 5 2 1 0 6 1 1 0 7 1 1 0 8 6 1 0 9 5 1 0 10 8 1 0 11 3 1 0 12 13 2 0 13 9 1 0 14 22 2 0 15 12 1 0 16 6 2 0 17 14 1 0 18 15 1 0 19 9 2 0 20 11 2 0 21 11 1 0 22 19 1 0 23 21 1 0 24 8 2 0 25 23 1 0 26 10 2 0 27 25 2 0 28 25 1 0 29 24 1 0 30 29 2 0 31 28 2 0 32 27 1 0 33 31 1 0 3 5 1 0 10 4 1 0 26 30 1 0 14 12 1 0 18 17 1 0 33 32 2 0 M END > 126739 > J. Med. Chem. 47(3)-2004 656-662 > PDE5 > 8.3439 $$$$ SciTegic07090714172D 34 40 0 0 0 0 999 V2000 -0.5831 -0.6682 0.0000 C 0 0 -0.5831 0.8382 0.0000 C 0 0 -2.8792 0.0850 0.0000 N 0 0 0.7168 1.5915 0.0000 N 0 0 -2.0045 1.2999 0.0000 C 0 0 0.7168 -1.4214 0.0000 C 0 0 -2.0045 -1.1298 0.0000 C 0 0 1.9924 -0.6682 0.0000 C 0 0 -2.4714 2.7262 0.0000 C 0 0 1.9924 0.8382 0.0000 C 0 0 -8.8656 -0.2430 0.0000 N 0 0 -11.2011 0.3365 0.0000 N 0 0 -4.3799 0.0850 0.0000 C 0 0 -4.2584 4.6168 0.0000 C 0 0 -3.9241 3.1505 0.0000 C 0 0 -9.8125 0.9039 0.0000 C 0 0 -7.3687 -0.1348 0.0000 C 0 0 -3.1731 5.6450 0.0000 C 0 0 -5.5673 5.3358 0.0000 O 0 0 0.7217 -2.6214 0.0000 O 0 0 -3.8202 6.9908 0.0000 O 0 0 -9.6337 -1.5166 0.0000 C 0 0 -11.0905 -1.1594 0.0000 C 0 0 -5.3088 6.7861 0.0000 C 0 0 -1.3801 3.7522 0.0000 C 0 0 -5.2183 1.3232 0.0000 C 0 0 -5.0309 -1.2682 0.0000 C 0 0 -1.7269 5.2318 0.0000 C 0 0 -6.7144 1.2150 0.0000 C 0 0 -6.5270 -1.3763 0.0000 C 0 0 3.3044 -1.4214 0.0000 C 0 0 3.3044 1.5915 0.0000 C 0 0 4.6043 -0.6682 0.0000 C 0 0 4.6043 0.8382 0.0000 C 0 0 2 1 2 0 3 7 1 0 4 2 1 0 5 2 1 0 6 1 1 0 7 1 1 0 8 6 1 0 9 5 1 0 10 8 2 0 11 17 1 0 12 16 2 0 13 3 1 0 14 15 1 0 15 9 2 0 16 11 1 0 17 30 1 0 18 28 1 0 19 14 1 0 20 6 2 0 21 18 1 0 22 11 1 0 23 22 2 0 24 19 1 0 25 9 1 0 26 13 2 0 27 13 1 0 28 25 2 0 29 26 1 0 30 27 2 0 31 8 1 0 32 10 1 0 33 31 2 0 34 33 1 0 5 3 1 0 4 10 1 0 29 17 2 0 34 32 2 0 18 14 2 0 24 21 1 0 23 12 1 0 M END > 149738 > J. Med. Chem. 48(6)-2005 2126-2133 > PDE5 > 8.7570 $$$$